WordNet
- abnormal redness of the skin resulting from dilation of blood vessels (as in sunburn or inflammation)
- occurring in or having many forms or shapes or appearances; "the multiform universe of nature and man"- John Dewey
PrepTutorEJDIC
- enlisted man下士官兵
- 紅斑(こうはん)(炎症などにより皮膚が異常に赤くなること)
- 多くの形態を持っている;多様な
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/19 19:25:26」(JST)
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- 1. 多形紅斑の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of erythema multiforme
- 2. 多形紅斑の治療 treatment of erythema multiforme
- 3. 薬疹 drug eruptions
- 4. 免疫正常患者における単純ヘルペスウイルス1型感染の防止 prevention of herpes simplex virus type 1 infection in immunocompetent patients
- 5. スティーブンス・ジョンソン症候群および中毒性表皮壊死融解症：病因、臨床症状、および診断 stevens johnson syndrome and toxic epidermal necrolysis pathogenesis clinical manifestations and diagnosis
English Journal
- [Current therapeutic indications of thalidomide and lenalidomide.]
- Ordi-Ros J1, Cosiglio FJ2.Author information 1Servicio de Medicina Interna, Hospital Vall d'Hebron, Instituto de Investigación Vall d'Hebron, Universidad Autónoma de Barcelona, Barcelona, España. Electronic address: Jordi@vhebron.net.2Servicio de Clínica Médica, Hospital Provincial del Centenario, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.AbstractThalidomide is a synthetic glutamic acid derivative first introduced in 1956 in Germany as an over the counter medications. It was thought to be one of the safest sedatives ever produced as it was effective in small doses, was not addictive, and did not have acute side-effects such as motor impairment, but was quickly removed from market after it was linked to cases of severe birth defects. The Food and Drug Administration approved use in the treatment of erythema nodosum leprosum. Further, it was shown its effectiveness in unresponsive dermatological conditions such as actinic prurigo, adult Langerhans cell hystiocytosis, aphthous stomatitis, Behçet syndrome, graft-versus-host disease, cutaneous sarcoidosis, erythema multiforme, Jessner-Kanof lymphocytic infiltration of the skin, Kaposi sarcoma, lichen planus, lupus erythematosus, melanoma, prurigo nodularis, pyoderma gangrenosum and others. In May 2006, it was approved for the treating multiple myeloma. New thalidomide analogues have been developed but lack clinical experience. This paper is a review of the history, pharmacology, mechanism of action, clinical applications and side effects of thalidomide and its analogues.
- Medicina clinica.Med Clin (Barc).2014 Apr 22;142(8):360-364. doi: 10.1016/j.medcli.2013.04.038. Epub 2013 Jul 3.
- Thalidomide is a synthetic glutamic acid derivative first introduced in 1956 in Germany as an over the counter medications. It was thought to be one of the safest sedatives ever produced as it was effective in small doses, was not addictive, and did not have acute side-effects such as motor impairme
- PMID 23830554
- Erythema exsudativum multiforme after a leishmania skin test.
- Wind BS1, Guimarães LH, Machado PR.Author information 1Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Rua João das Botas S/N, Canela, Salvador; Universidade Federal da Bahia, Salvador, Bahia, Brazil.AbstractAbstract. A 45-year-old otherwise healthy male from an endemic region for Leishmania braziliensis infection in Bahia, Brazil, presented with three erosive hemorrhagic infiltrated plaques on the left shin accompanied with lymphadenopathy in the groin since one month (Figure 1). A Leishmania skin test performed on the left forearm was strongly positive (20 × 18 mm).1 Two days later, the patient felt sick and feverish. Painful erythematous target lesions developed on the palms and scapula together with conjunctivitis (Figure 2). Histopathology confirmed erythema exsudativum multiforme (EEM) (Figure 3). Both EEM and cutaneous leishmaniasis were successfully treated with a 5-day course of prednisone 20 mg, and a 20-day course of intravenous pentavalent antimony, respectively.
- The American journal of tropical medicine and hygiene.Am J Trop Med Hyg.2014 Apr;90(4):587-8. doi: 10.4269/ajtmh.13-0166.
- Abstract. A 45-year-old otherwise healthy male from an endemic region for Leishmania braziliensis infection in Bahia, Brazil, presented with three erosive hemorrhagic infiltrated plaques on the left shin accompanied with lymphadenopathy in the groin since one month (Figure 1). A Leishmania skin test
- PMID 24696403
- Circulating plakin autoantibodies in a patient with erythema multiforme major: Are they pathogenic or a manifestation of epitope spreading?
- Ellis E1, Sidhu S.Author information 1Department of Dermatology, Flinders Medical Centre, Bedford Park, South Australia, Australia.AbstractErythema multiforme is a well-recognised entity but its pathogenesis remains elusive. Theories hypothesise a cell-mediated immune pathogenesis, however recent case reports have observed autoantibodies to the plakin family of proteins, suggesting a role for the humoral immune system. We present a case of erythema multiforme major with circulating desmoplakin autoantibodies in a 36-year old woman who was previously diagnosed with pemphigoid gestationis. The close correlation between the concentration of these autoantibodies and the severity of clinical disease strongly suggests a pathogenic role in her disease. As previous case reports have proposed, these autoantibodies may be directly pathogenic. Alternatively, the epiphenomenon of epitope spreading must be considered in the subset of patients with erythema multiforme major.
- The Australasian journal of dermatology.Australas J Dermatol.2014 Apr 1. doi: 10.1111/ajd.12162. [Epub ahead of print]
- Erythema multiforme is a well-recognised entity but its pathogenesis remains elusive. Theories hypothesise a cell-mediated immune pathogenesis, however recent case reports have observed autoantibodies to the plakin family of proteins, suggesting a role for the humoral immune system. We present a cas
- PMID 24689866
Japanese Journal
- 症例報告 多形紅斑様皮疹を呈し,非典型的な臨床経過をとった62歳男性の麻疹
- 笠井 弘子,甲田 とも,木花 光 [他]
- 臨床皮膚科 65(13), 1065-1070, 2011-12
- NAID 40019086369
- 症例 ソラフェニブによる多形紅斑型薬疹の1例
- 永松 麻紀,東 祥子,小澤 健太郎 [他]
- 皮膚科の臨床 53(10), 1399-1402, 2011-10
- NAID 40019022246
Related Links
- Causes Erythema multiforme is a type of hypsersensitivity reaction. It occurs in response to medicines, infections, or illness. Medications that can cause this reaction include: Barbiturates Penicillins Phenytoin
- Erythema multiforme is a skin disorder that comes from an allergic reaction or infection. ... Causes, incidence, and risk factors Erythema multiforme is a type of hypsersensitivity reaction. It occurs in response to ...
- Erythema multiforme. 75 likes · 0 talking about this. Erythema multiforme is a skin condition of unknown cause, possibly mediated by deposition of immune complex (mostly IgM) in the superficial microvasculature of the skin and oral ...
Related Pictures
★リンクテーブル★
| リンク元 | 「100Cases 39」「多形滲出性紅斑」「EM」「多形性紅斑」 |
| 拡張検索 | 「postherpetic erythema multiforme」 |
| 関連記事 | 「multiforme」 |
「100Cases 39」
- erratic adj. adj. 軌道の定まらない。一貫性のない、不安定な、不規則な
- bowel motion 腸運動、排便
- fit adj. adj. 体調がよい、健康で
- emaciated adj.
- glisten vi. ぴかぴか光る
- dislodge
- palliative
- erythema multiforme 多形紅斑
- dermatitis herpetiformis 疱疹状皮膚炎
- itch 痒み
- itching
- celiac disease セリアック病
- herpes gestationis 妊娠性疱疹
- 皮膚の水疱
- 83歳 男性
- 主訴：皮膚と口内における多数の水疱
- 現病歴：水疱は2日前より出現。水疱は破れやすく、赤色の有痛性病変が残る。3ヶ月前から5kg体重が減少しており、食欲が減退している。患者は体調の不調を自覚してた。排便習慣が不規則になり、排便にいくらか血液を認めた。
- 既往歴：生来、健康であり、既往なし。
- 生活歴：一人住まい
- 嗜好歴：喫煙・飲酒無し
- 服薬歴：処方薬なし。マルチビタミンタブレットは体調の不調を感じてから薬局で購入している。これ以外て薬を購入していない。
- 身体所見 examination
- 全身：emaciateで調子悪そうである
- 皮膚：全身の皮膚に水疱
- 口内：びらん(sore)あり sore→有痛性のびらん・潰瘍
- 脈拍：102/min、irregularly irregular → 不規則な不整脈 → ( )
- 血圧：160/78 mmHg
- 上記以外、心臓、呼吸器系に異常を認めない。
- 腹部触診：6cmの硬い結節を肝の辺縁に触知。可動性のある硬性の腫瘤を左腸骨窩に触知。
- 直腸診：鮮血色の血液と糞便の混合物が認められる
- 検査 examination
- 低値：Hb, MCV,Alb
- 高値：AlP
- Q1. まず皮膚病変の診断をつけろ。
- Q2. 次に皮膚病変と患者の病態を関連づけてみろ。
- A. 尋常性天疱瘡
- 特徴：表皮内水疱、弛緩性水疱、ニコルスキー現象、口内びらん、
- ・病因：癌腫、リンパ腫、胸腺腫、全身性エリテマトーデス、特定の薬物(ペニシラミン、カプトプリル)などによる
- 治療：ステロイド、免疫抑制薬
- 鑑別疾患
- ・水疱性類天疱瘡：緊満性水疱、水疱は尋常性天疱瘡に比べて破れにくく大型になりやすい。
- ・多形性紅斑：中心に水疱を伴った的形病変(target-shaped lesion with central blisters)。よく全身紅皮症と粘膜潰瘍と伴う(スティーブン・ジョンソン症候群)。病因は単純ヘルペスウイルス、薬剤(スルフォナミド)、悪性腫瘍。
- ・疱疹状皮膚炎：肘、膝、顔面に小水疱病変(vesicular lesion)が形成される。vesicleはblister(<0.5cm)より小さく、ひっかくことで破裂する。非常にかゆい。セリアック病に合併することがある
- ・その他の疾患
- ・糖尿病
- ・妊娠性疱疹
- ・家族性水疱疾患
- まとめ
- ・悪性腫瘍に合併しうる(→腫瘍の存在下で皮膚病変が出現したのであれば腫瘍随伴性天疱瘡と診断されるべき)、
- ・天疱瘡は気づかないうちに体液を喪失し、あるいは水疱からの感染の結果としての敗血症が生命を脅かす。
「多形滲出性紅斑」
- 英
- erythema exsudativum multiforme, erythema multiforme exudativum, EEM
- 同
- 多形紅斑 erythema multiforme EM
- 関
- スティーブンス・ジョンソン症候群 Stevens-Johnson syndrome SJS
特徴
- やや隆起する10mm大ほどの特徴的な環状浮腫性紅斑が手背や関節部伸側などに、左右対称性に多発
疫学
- 女性に多い
原因
- 感染症(単純ヘルペスウイルス、肺炎マイコプラズマ)、薬剤に対するアレルギー
参考
- 写真
- http://www.healthopedia.com/pictures/erythema-multiforme.html
- http://www.skinsite.com/info_erythema_multiforme.htm
「EM」
- エリスロマイシン erythromycin
- 多形紅斑 erythema multiforme
- 期待値最大化 expectation-maximization
- 電子顕微鏡 electron microscope
- 遊走性紅斑 erythema migrans
「多形性紅斑」
「postherpetic erythema multiforme」
「multiforme」
- adj.
- (後置するラテン語形容詞)多形の
- ex.