英: regulated on activation normal T cell expressed and secreted
関: ケモカイン、CCL5

単球のケモカイン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/26 10:48:00」(JST)

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Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene.^[1] It is also known as RANTES (regulated on activation, normal T cell expressed and secreted).

Function

CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells.^[2] It is also an HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.^[1]

RANTES was first identified in a search for genes expressed "late" (3–5 days) after T cell activation. It was subsequently determined to be a CC chemokine and expressed in more than 100 human diseases. RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13).^[3]^[4]^[5]^[6] RANTES, along with the related chemokines MIP-1alpha and MIP-1beta, has been identified as a natural HIV-suppressive factor secreted by activated CD8+ T cells and other immune cells.^[7] Recently, the RANTES protein has been engineered for in vivo production by Lactobacillus bacteria, and this solution is being developed into a possible HIV entry-inhibiting topical microbicide.^[8]

Interactions

CCL5 has been shown to interact with CCR3,^[9]^[10] CCR5^[10]^[11]^[12] and CCR1.^[10]^[12]

CCL5 also activates the G-protein coupled receptor GPR75.^[13]

References

^ ^a ^b Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C (March 1990). "Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12". Genomics 6 (3): 548–53. doi:10.1016/0888-7543(90)90485-D. PMID 1691736.
^ Maghazachi AA, Al-Aoukaty A, Schall TJ (February 1996). "CC chemokines induce the generation of killer cells from CD56+ cells". Eur. J. Immunol. 26 (2): 315–9. doi:10.1002/eji.1830260207. PMID 8617297.
^ Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM (August 1988). "A human T cell-specific molecule is a member of a new gene family". J. Immunol. 141 (3): 1018–25. PMID 2456327.
^ Alan M. Krensky (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co. ISBN 1-57059-253-5.
^ Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (January 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
^ Song A, Nikolcheva T, Krensky AM (October 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunol. Rev. 177: 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
^ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells". Science 270 (5243): 1811–5. doi:10.1126/science.270.5243.1811. PMID 8525373.
^ Vangelista L, Secchi M, Liu X, Bachi A, Jia L, Xu Q, Lusso P (July 2010). "Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockers". Antimicrob. Agents Chemother. 54 (7): 2994–3001. doi:10.1128/AAC.01492-09. PMC 2897324. PMID 20479208. Lay summary – Science Daily.
^ Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS (May 1996). "Cloning, expression, and characterization of the human eosinophil eotaxin receptor". J. Exp. Med. 183 (5): 2349–54. doi:10.1084/jem.183.5.2349. PMC 2192548. PMID 8642344.
^ ^a ^b ^c Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". Eur. J. Immunol. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371.
^ Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L (October 2003). "Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages". Biochim. Biophys. Acta 1617 (1-2): 80–8. doi:10.1016/j.bbamem.2003.09.006. PMID 14637022.
^ ^a ^b Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". J. Biol. Chem. 276 (14): 10620–6. doi:10.1074/jbc.M010867200. PMID 11116158.
^ Ignatov A, Robert J, Gregory-Evans C, Schaller HC (November 2006). "RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75". Br. J. Pharmacol. 149 (5): 490–7. doi:10.1038/sj.bjp.0706909. PMC 2014681. PMID 17001303.

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CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.

Raghu H1,2, Lepus CM1,2, Wang Q1,2, Wong HH1,2, Lingampalli N1,2, Oliviero F3, Punzi L3, Giori NJ2,4, Goodman SB5, Chu CR2,4, Sokolove JB1,2, Robinson WH1,2.
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Japanese Journal

RANTES expression induced by Toll-like receptor 4 ligand in rat airway smooth muscle cells

Okayasu Kaori,Tamaoka Meiyo,Takayama Satoshi,Miyazaki Yasunari,Sumi Yuki,Inase Naohiko,Yoshizawa Yasuyuki
Journal of medical and dental sciences 57(4), 193-201, 2010-12
NAID 110007870511

O10-3 ヒト気道上皮細胞におけるリゾホスファチジン酸のRANTES産生抑制効果(O10 気道上皮細胞2,口演,第60回日本アレルギー学会秋季学術大会)

松崎晋一,石塚全,青木悠,小野昭浩,宇津木光克,久田剛志,土橋邦生,岡島史和,森昌朋
アレルギー 59(9・10), 1378, 2010-10-30
NAID 110008083966

Related Pictures

MIP-1α, MIP-1β, RANTES, and ATAC/lymphotactin function together with IFN-γ as type Human RANTES ELISA Kit (ab100633) | Abcam Chemokine ccl5; CCL5 Chemokine; RANTES Rantes Rantes Evodia rutaecarpa and Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Anti-Inflammatory Dimethylfumarate: A Potential New Therapy for Asthma? : Figure 3 Rantes

★リンクテーブル★

リンク元	「サイトカイン」「母乳」「ケモカイン」「ランテス」「chemokine CCL5」

「サイトカイン」

Chemokine (C-C motif) ligand 5
	; PDB rendering based on 1eqt.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW
Identifiers
Symbols	CCL5 ; D17S136E; RANTES; SCYA5; SIS-delta; SISd; TCP228; eoCP
External IDs	OMIM: 187011 MGI: 98262 HomoloGene: 2244 ChEMBL: 1275217 GeneCards: CCL5 Gene
Gene ontology
Molecular function	• phosphatidylinositol phospholipase C activity; • protein kinase activity; • protein binding; • chemokine activity; • phospholipase activator activity; • receptor signaling protein tyrosine kinase activator activity; • CCR1 chemokine receptor binding; • CCR4 chemokine receptor binding; • CCR5 chemokine receptor binding; • chemoattractant activity; • chemokine receptor binding; • protein homodimerization activity; • protein self-association; • chemokine receptor antagonist activity;
Cellular component	• extracellular region; • extracellular space; • cytoplasm;
Biological process	• MAPK cascade; • dendritic cell chemotaxis; • monocyte chemotaxis; • regulation of chronic inflammatory response; • protein phosphorylation; • calcium ion transport; • cellular calcium ion homeostasis; • exocytosis; • chemotaxis; • inflammatory response; • leukocyte cell-cell adhesion; • cell-cell signaling; • response to virus; • response to toxic substance; • positive regulation of activation of JAK2 kinase activity; • positive regulation of macrophage chemotaxis; • positive regulation of T cell chemotaxis; • positive regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of smooth muscle cell migration; • positive regulation of cell migration; • positive regulation of cellular biosynthetic process; • activation of phospholipase D activity; • lipopolysaccharide-mediated signaling pathway; • positive regulation of cell-cell adhesion mediated by integrin; • positive regulation of homotypic cell-cell adhesion; • positive regulation of T cell proliferation; • neutrophil activation; • positive regulation of phosphorylation; • positive regulation of tyrosine phosphorylation of STAT protein; • protein kinase B signaling; • cellular protein complex assembly; • negative regulation by host of viral transcription; • cellular response to fibroblast growth factor stimulus; • positive regulation of viral genome replication; • negative regulation of viral genome replication; • positive regulation of innate immune response; • negative regulation of G-protein coupled receptor protein signaling pathway; • positive regulation of cell adhesion; • positive regulation of translational initiation; • positive regulation of JAK-STAT cascade; • eosinophil chemotaxis; • macrophage chemotaxis; • positive regulation of smooth muscle cell proliferation; • positive regulation of epithelial cell proliferation; • regulation of T cell activation; • positive chemotaxis; • protein tetramerization; • positive regulation of calcium ion transport; • positive regulation of protein tyrosine kinase activity; • chemokine-mediated signaling pathway; • negative regulation of chemokine-mediated signaling pathway; • negative regulation of T cell apoptotic process; • positive regulation of T cell apoptotic process; • cellular response to interferon-gamma; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • cellular response to organic cyclic compound; • positive regulation of monocyte chemotaxis; • negative regulation of macrophage apoptotic process; • positive regulation of T cell migration; • positive regulation of natural killer cell chemotaxis;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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　　[★]

cyto=cell kin(e)=small substance

ex. manikine

細胞が分泌する糖タンパク質で、生物活性(増殖・分化・タンパク産生誘導などを)を有するもの

英: cytokine, cytokines
関: サイトカイン受容体、インターロイキン、リンホカイン

生態情報伝達方式

傍分泌系、自己分泌系により情報を伝達する。局所ホルモンともいえる(ホルモンは血流を介して他臓器に働く)

産生細胞・機能による分類名

機能

機能	サブグループ	サイトカイン	標的	機能
炎症性サイトカイン	TNFファミリー	TNF-α	白血球、上皮細胞	活性化
	インターロイキン	IL-1	上皮細胞、リンパ球	活性化
		IL-6	種々の細胞	活性化
		IL-8	白血球	炎症部位遊走
T細胞の増殖・分化	インターロイキン	IL-2	T細胞	活性化。増殖
		IL-4	T細胞	増殖
		IL-4	Th2細胞	分化誘導
		IL-12	Th1細胞	分化誘導
	インターフェロン	IFN-γ	Th2細胞	分化抑制
B細胞の増殖・分化	インターロイキン	IL-2	B細胞	活性化
		IL-4	B細胞	活性化、増殖、分化
		IL-5	B細胞	活性化、増殖
		IL-6	B細胞	増殖、分化
		TGF-β	B細胞	分化(IgA分泌)
アレルギー調節サイトカイン	インターロイキン	IL-3	肥満細胞	増殖、分化促進
		IL-4	B細胞	IgEクラススイッチ促進
		IL-5	好酸球	増殖、分化促進
		IL-13	B細胞	IgEクラススイッチ促進
	インターフェロン	IFN-γ	B細胞	IgEクラススイッチ抑制
走化性サイトカイン(ケモカイン)	CCケモカイン	MIP-1	好中球	遊走
		MIP-2	好中球
		RANTES	単球
	CXCケモカイン	IL-8	好中球、リンパ球、好塩基球
	CXCケモカイン	SDF-1	好中球、リンパ球、好塩基球
造血系サイトカイン		SCF
	インターロイキン	IL-7
		erythropoietin
	コロニー刺激因子	GM-CSF
		G-CSF
		M-CSF