UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 心不全における一酸化窒素、その他のホルモン、サイトカイン、およびケモカイン nitric oxide other hormones cytokines and chemokines in heart failure
2. 移植免疫 transplantation immunobiology
3. 肝線維症の非侵襲的評価：血清学的検査および画像診断 noninvasive assessment of hepatic fibrosis overview of serologic and radiographic tests
4. 静脈血栓症の原因の概要 overview of the causes of venous thrombosis
5. 肥満細胞由来のメディエーター mast cell derived mediators

English Journal

Intracerebroventricular administration of lupus serum induces microglia activation and leukocyte adhesion in the cerebromicrovasculature of mice.

Wang X, Li Y, Wang Y, Feng Q, Yang P, Qin L.
Journal of neuroimmunology. 2019 Sep;334()576994.
Central nervous system (CNS) involvement is commonly seen in the patients with system lupus erythematosus (SLE). Mechanisms underlying CNS damage in SLE remain largely unknown. Accumulating evidence suggest that activation of microglia in CNS plays an important role in the inflammatory responses in
PMID 31207553

miR‑589‑5p is downregulated in prostate cancer and regulates tumor cell viability and metastasis by targeting CCL‑5.

Ji L, Jiang X, Mao F, Tang Z, Zhong B.
Molecular medicine reports. 2019 Aug;20(2)1373-1382.
Prostate cancer is one of the most common human malignancies, which represents a serious threat to health, and microRNAs (miRNAs/miRs) have been reported to be closely associated with the progression and development of prostate cancer. The present study aimed to investigate the expression patterns,
PMID 31173214

CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation.

Piryani SO, Kam AYF, Vu UT, Chao NJ, Doan PL.
Stem cell reports. 2019 Jul;13(1)76-90.
Hematopoietic stem and progenitor cells (HSPCs) depend on regulatory cytokines from the marrow microenvironment. From an unbiased cytokine screen of murine marrow supernatants, we identified C-C motif chemokine ligand 5 (CCL5) as an endothelial cell-secreted hematopoietic growth factor. Following tr
PMID 31155503

Anti-inflammatory Actions of Herbal Formula Gyejibokryeong-Hwan Regulated by Inhibiting Chemokine Production and STAT1 Activation in HaCaT Cells

Jeong Soo-Jin,Lim Hye-Sun,Seo Chang-Seob [他],Jin Seong-Eun,Yoo Sae-Rom,Lee Nari,Shin Hyeun-Kyoo
Biological and Pharmaceutical Bulletin 38(3), 425-434, 2015
… Exposure to the proinflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) significantly increased HaCaT cell production of the following chemokines: macrophage-derived chemokine (MDC)/CCL22; … regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL5; … Our findings indicate that GJBRH impairs TNF-α and IFN-γ-mediated inflammatory chemokine production and STAT1 phosphorylation in keratinocytes. …
NAID 130004872285

Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice

Sasaki Soichiro,Baba Tomohisa,Shinagawa Kei,Matsushima Kouji,Mukaida Naofumi
International Journal of Cancer 135(6), 1297-1306, 2014-09-15
… Previously, it's been observed that these cancers have a lot of chemokine CCL3 hanging around. … without CCL3 and CCL5 bringing in fibroblasts, the tumor development slowed. …
NAID 120005463351

The Water-Extracted Ampelopsis brevipedunculata Downregulates IL-1β, CCL5, and COX-2 Expression via Inhibition of PKC-Mediated JNK/NF-κB Signaling Pathways in Human Monocytic Cells

Le Minh Quan,Kim Man Sub,Song Yong Seok,Noh Whoe Nyoung,Chun Se Chul,Yoon Do Young
Journal of Pharmacological Sciences, 2014
… THP-1 cells activated by PMA in the presence or absence of A.bre demonstrated that a water-extract of A.bre inhibited the expression of pro-inflammatory cytokine IL-1β and chemokine CCL-5 in a dose-dependent manner. …
NAID 130004933180