1. an antibiotic (trade name Achromycin) derived from microorganisms of the genus Streptomyces and used broadly to treat infections (同)Achromycin

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/19 23:00:00」(JST)

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English Journal

  • The mixture toxicity of environmental contaminants containing sulfonamides and other antibiotics in Escherichia coli: Differences in both the special target proteins of individual chemicals and their effective combined concentration.
  • Long X1, Wang D1, Lin Z2, Qin M1, Song C1, Liu Y3.
  • Chemosphere.Chemosphere.2016 Sep;158:193-203. doi: 10.1016/j.chemosphere.2016.05.048. Epub 2016 Jun 4.
  • Organisms in the environment are exposed to mixtures of multiple contaminants, leading to serious environmental harm. These mixtures pose an ecological risk and have attracted an increasing amount of attention; however there has been little in-depth research the toxicity of mixtures, such as antibio
  • PMID 27269994
  • Study of spatial and temporal distribution of antimicrobial in water and sediments from caging fish farms by on-line SPE-LC-MS/MS.
  • Monteiro SH1, Francisco JG2, Andrade GC2, Botelho RG2, Figueiredo LA2, Tornisielo VL2.
  • Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.J Environ Sci Health B.2016 Sep;51(9):634-43. doi: 10.1080/03601234.2016.1181917. Epub 2016 Jun 1.
  • An on-line solid phase extraction liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) method for the determination of 12 antimicrobials in sediment and surface water was developed and validated. Furthermore, the spatial and temporal antimicrobials distributions in the sediment and in the w
  • PMID 27249158
  • Ti/β-PbO2 versus Ti/Pt/β-PbO2: Influence of the platinum interlayer on the electrodegradation of tetracyclines.
  • Nunes MJ1, Monteiro N1, Pacheco MJ1, Lopes A1, Ciríaco L1.
  • Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.J Environ Sci Health A Tox Hazard Subst Environ Eng.2016 Aug 23;51(10):839-46. doi: 10.1080/10934529.2016.1181455. Epub 2016 May 26.
  • The behaviors of the electrodes Ti/PbO2 and Ti/Pt/PbO2 as anodes in the electro-oxidation of two antibiotics-tetracycline and oxytetracycline-were evaluated at different applied current densities, to evaluate the influence of the Pt interlayer. In the preparation of the electrodes, the electrodeposi
  • PMID 27230959

Japanese Journal

  • マクロライド耐性マイコプラズマに対する抗菌薬療法
  • Community-acquired Pneumonia Caused by Macrolide-resistant Mycoplasma pneumoniae in Adults
  • Hanada Shigeo,Morozumi Miyuki,Takahashi Yui,Mochizuki Sayaka,Sato Toshitaka,Suzuki Shinko,Uruga Hironori,Takaya Hisashi,Miyamoto Atsushi,Morokawa Nasa,Ubukata Kimiko,Kishi Kazuma
  • Internal Medicine 53(15), 1675-1678, 2014
  • … In seven of the eight cases of MRMP initially treated with macrolides, the patients did not improve, and a marked improvement was observed only after the antibiotic regimen was modified to include fluoroquinolones or tetracyclines. …
  • NAID 130004678363
  • Antibiotic residues in food: the African scenario
  • Darwish Wageh Sobhy,Eldaly Elsaid A.,El-Abbasy Mohamed Tharwat,Ikenaka Yoshinori,Nakayama Shouta,Ishizuka Mayumi
  • Japanese Journal of Veterinary Research 61(Supplement), S13-S22, 2013-02
  • … these residues have exceeded theWHO maximum residue levels in many cases.It has been reported that tetracyclines are the most predominantly prescribed antibioticsin Africa, and of all antibiotic-associated residues they represent 41% of cases, followed byβ-lactams at 18%. …
  • NAID 120005228430

Related Links

Tetracyclines Definition Tetracyclines are medicines that kill certain infection-causing microorganisms. Purpose Tetracyclines are called "broad-spectrum" antibiotics, because they can be used to treat a wide variety of infections.
The tetracyclines are broad-spectrum antibiotics with similar antimicrobial features, but they differ somewhat from one another in terms of their spectra and pharmacokinetic disposition. Classes There are 3 naturally occurring ...

拡張検索tetracyclines antibiotics



antibacterial drug, antibacterial
first aid step 1 2006 p.165


  • 細菌/微生物に静菌作用、殺菌作用を示す物質。結果として、人において病原性を除去する目的で使用される。
  • このうち、微生物によって産生される物質を抗生物質と呼ぶ


first aid step 1 2006 p.165
  Mechanism of action Drugs
1 Block cell wall synthesis by inhibition of peptidoglycan cross-linking penicillin, ampicillin, ticarcillin, piperacillin, imipenem, aztreonam, cephalosporins
2 Block peptidoglycan synthesis bacitracin, vancomycin, cycloserine
3 Disrupt bacterial/fungal cell membranes polymyxins
4 Disrupt fungal cell membranes amphotericin B, nystatin, fluconazole/azoles
5 Block nucleotide synthesis sulfonamides, trimethoprim
6 Block DNA topoisomerases quinolones
7 Block mRNA synthesis rifampin
8 Block protein synthesis at 50S ribosomal subunit chloramphenicol, erythromycin/macrolides, lincomycin, clindamycin, streptogramins (quinupristin, dalfopristin), linezolid
9 Block protein synthesis at 30S ribosomal subunit aminoglycosides, tetracyclines, spectinomycin
 ATuSi → あつし


  • 濃度依存性:アミノグリコシド系抗菌薬、ニューロキノロン系抗菌薬
  • 時間依存性:βラクタム系抗菌薬



尾内一信 ; 第 39 回日本小児感染症学会教育講演 2 小児感染症の抗菌薬療法 -耐性菌時代の適正使用-
感染臓器・臨床診断 原因菌 投与期間(抗菌薬)
髄膜炎 インフルエンザ菌 7-10日
肺炎球菌 10-14日
髄膜炎菌 7-10日
GBS,腸内細菌,リステリア 21日
中耳炎 <2 歳 10日
2 歳≦ 5-7日
咽頭炎 A 群連鎖球菌 10日(ペニシリン系薬)
肺炎 肺炎球菌,インフルエンザ菌 解熱後3-4日
黄色ブドウ球菌 3-4週間
マイコプラズマ,クラミジア 10-21日
腎臓、膀胱炎、腎盂腎炎 大腸菌,プロテウス,腸球菌 3日
骨髄炎 黄色ブドウ球菌 21日
連鎖球菌,インフルエンザ菌 14日


感染レジマニュ p.27
骨髄炎 4-6週
耳鼻咽喉 中耳炎 5-7日
副鼻腔炎 5-14日
A群溶連菌咽頭炎 10日
肺炎 肺炎球菌 7-10日 or 解熱後3日間
インフルエンザ菌 10-14日
マイコプラズマ 14日(7-10日)
レジオネラ 21日
肺化膿症 28-42日
心臓 感染性心内膜炎 α連鎖球菌 2-4週
黄色ブドウ球菌 4-6週
消化管 腸炎 赤痢菌 3日
チフス 14日(5-7日)
腹膜炎 特発性 5日
二次性 10-14日
胆肝膵 肝膿瘍 細菌性 4-8週
アメーバ性 10日
尿路 膀胱炎 3日
急性腎盂腎炎 14日(7-10日)
急性腎盂腎炎・再発 6週
慢性前立腺炎 1-3ヶ月
髄腔 髄膜炎 インフルエンザ菌 7-10日
肺炎球菌 10-14日
リステリア 21日
敗血症 敗血症 コアグラーゼ陰性ブドウ球菌 5-7日
黄色ブドウ球菌 28日(14日)
グラム陰性桿菌 14日(7-14日)
カンジダ 血液培養陰性化後, 14日



  • Antibiotics to avoid in pregnancy
  • Sulfonamides––kernicterus.
  • Aminoglycosides––ototoxicity.
  • Fluoroquinolones––cartilage damage.
  • Erythromycin––acute cholestatic hepatitis in mom
(and clarithromycin––embryotoxic).
  • Metronidazole––mutagenesis.
  • Tetracyclines––discolored teeth, inhibition of bone growth.
  • Ribavirin (antiviral)––teratogenic.
  • Griseofulvin (antifungal)––teratogenic.
  • Chloramphenicol––“gray baby.”
  • SAFE Moms Take Really Good Care.


  • βラクタム系
  • エリスロマイシン、アジスロマイシン


  • 抗菌薬インターネットブック




tetracyclines, tetracycline antibacterials、tetracycline antibiotics, tetracycline derivatives

tetracyclines antibiotics」

  [★] テトラサイクリン系抗菌薬


  [★] テトラサイクリン, TC