1. an antibiotic used to treat gonorrhea

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/17 12:50:16」(JST)

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English Journal

  • Metabolomic approach to optimizing and evaluating antibiotic treatment in the axenic culture of cyanobacterium Nostoc flagelliforme.
  • Han PP1, Jia SR, Sun Y, Tan ZL, Zhong C, Dai YJ, Tan N, Shen SG.
  • World journal of microbiology & biotechnology.World J Microbiol Biotechnol.2014 Sep;30(9):2407-18. doi: 10.1007/s11274-014-1666-4. Epub 2014 May 16.
  • The application of antibiotic treatment with assistance of metabolomic approach in axenic isolation of cyanobacterium Nostoc flagelliforme was investigated. Seven antibiotics were tested at 1-100 mg L(-1), and order of tolerance of N. flagelliforme cells was obtained as kanamycin > ampicillin
  • PMID 24832956
  • Re-identification of Aeromonas isolates from rainbow trout and incidence of class 1 integron and β-lactamase genes.
  • Vega-Sánchez V1, Latif-Eugenín F2, Soriano-Vargas E1, Beaz-Hidalgo R2, Figueras MJ3, Aguilera-Arreola MG4, Castro-Escarpulli G5.
  • Veterinary microbiology.Vet Microbiol.2014 Aug 27;172(3-4):528-33. doi: 10.1016/j.vetmic.2014.06.012. Epub 2014 Jun 22.
  • Forty-eight Aeromonas isolates from rainbow trout previously identified by the 16S rDNA-RFLP technique were re-identified using 2 housekeeping genes (gyrB and rpoD). After sequencing the prevalences of the species were A. veronii (29.2%), A. bestiarum (20.8%), A. hydrophila (16.7%), A. sobria (10.4%
  • PMID 25008317
  • Antimicrobial susceptibility monitoring of respiratory tract pathogens isolated from diseased cattle and pigs across Europe: The VetPath study.
  • de Jong A1, Thomas V2, Simjee S3, Moyaert H4, El Garch F5, Maher K6, Morrissey I6, Butty P7, Klein U8, Marion H9, Rigaut D10, Vallé M11.
  • Veterinary microbiology.Vet Microbiol.2014 Aug 6;172(1-2):202-15. doi: 10.1016/j.vetmic.2014.04.008. Epub 2014 Apr 21.
  • VetPath is an ongoing pan-European antibiotic susceptibility monitoring programme collecting pathogens from diseased antimicrobial non-treated cattle, pigs and poultry. In the current study, 1001 isolates from cattle and pig respiratory tract infections were tested for their antimicrobial susceptibi
  • PMID 24837878

Japanese Journal

  • Biosynthetic approach for the production of new aminoglycoside derivative(BIOCHEMICAL ENGINEERING)
  • Nepal Keshav Kumar,Yoo Jin Cheol,Sohng Jae Kyung
  • Journal of bioscience and bioengineering 110(1), 109-112, 2010-07
  • … Here, we report a biosynthetic approach for the fusion of spectinomycin and kanamycin biosynthetic gene clusters to yield the new aminoglycoside derivative, oxykanamycinC, in a non-aminoglycoside producing heterologous host. …
  • NAID 110007681455
  • An RNA helicase, CrhR, regulates the low-temperature-inducible expression of heat-shock genes groES, groEL1 and groEL2 in Synechocystis sp. PCC 6803
  • Prakash Jogadhenu S. S.,Krishna Pilla Sankara,Sirisha Kodru,Kanesaki Yu,Suzuki Iwane,Shivaji Sisinthy,Murata Norio,鈴木 石根
  • Microbiology 156(2), 442-451, 2010-02
  • … In the present study, we replaced the crhR gene with a spectinomycin-resistance gene cassette. …
  • NAID 120002808044

Related Links

Sigma-Aldrich offers Sigma-S0692, Spectinomycin for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Biochem/physiol Actions Mode of Action: Spectinomycin acts ...
spectinomycin spec·ti·no·my·cin (spěk'tə-nō-mī'sĭn) n. A broad-spectrum antibiotic obtained from a species of gram-negative bacteria or produced synthetically, used especially in the treatment of gonorrhea that is resistant to ...

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拡張検索spectinomycin hydrochloride



antibacterial drug, antibacterial
first aid step 1 2006 p.165


  • 細菌/微生物に静菌作用、殺菌作用を示す物質。結果として、人において病原性を除去する目的で使用される。
  • このうち、微生物によって産生される物質を抗生物質と呼ぶ


first aid step 1 2006 p.165
  Mechanism of action Drugs
1 Block cell wall synthesis by inhibition of peptidoglycan cross-linking penicillin, ampicillin, ticarcillin, piperacillin, imipenem, aztreonam, cephalosporins
2 Block peptidoglycan synthesis bacitracin, vancomycin, cycloserine
3 Disrupt bacterial/fungal cell membranes polymyxins
4 Disrupt fungal cell membranes amphotericin B, nystatin, fluconazole/azoles
5 Block nucleotide synthesis sulfonamides, trimethoprim
6 Block DNA topoisomerases quinolones
7 Block mRNA synthesis rifampin
8 Block protein synthesis at 50S ribosomal subunit chloramphenicol, erythromycin/macrolides, lincomycin, clindamycin, streptogramins (quinupristin, dalfopristin), linezolid
9 Block protein synthesis at 30S ribosomal subunit aminoglycosides, tetracyclines, spectinomycin
 ATuSi → あつし


  • 濃度依存性:アミノグリコシド系抗菌薬、ニューロキノロン系抗菌薬
  • 時間依存性:βラクタム系抗菌薬



尾内一信 ; 第 39 回日本小児感染症学会教育講演 2 小児感染症の抗菌薬療法 -耐性菌時代の適正使用-
感染臓器・臨床診断 原因菌 投与期間(抗菌薬)
髄膜炎 インフルエンザ菌 7-10日
肺炎球菌 10-14日
髄膜炎菌 7-10日
GBS,腸内細菌,リステリア 21日
中耳炎 <2 歳 10日
2 歳≦ 5-7日
咽頭炎 A 群連鎖球菌 10日(ペニシリン系薬)
肺炎 肺炎球菌,インフルエンザ菌 解熱後3-4日
黄色ブドウ球菌 3-4週間
マイコプラズマ,クラミジア 10-21日
腎臓、膀胱炎、腎盂腎炎 大腸菌,プロテウス,腸球菌 3日
骨髄炎 黄色ブドウ球菌 21日
連鎖球菌,インフルエンザ菌 14日


感染レジマニュ p.27
骨髄炎 4-6週
耳鼻咽喉 中耳炎 5-7日
副鼻腔炎 5-14日
A群溶連菌咽頭炎 10日
肺炎 肺炎球菌 7-10日 or 解熱後3日間
インフルエンザ菌 10-14日
マイコプラズマ 14日(7-10日)
レジオネラ 21日
肺化膿症 28-42日
心臓 感染性心内膜炎 α連鎖球菌 2-4週
黄色ブドウ球菌 4-6週
消化管 腸炎 赤痢菌 3日
チフス 14日(5-7日)
腹膜炎 特発性 5日
二次性 10-14日
胆肝膵 肝膿瘍 細菌性 4-8週
アメーバ性 10日
尿路 膀胱炎 3日
急性腎盂腎炎 14日(7-10日)
急性腎盂腎炎・再発 6週
慢性前立腺炎 1-3ヶ月
髄腔 髄膜炎 インフルエンザ菌 7-10日
肺炎球菌 10-14日
リステリア 21日
敗血症 敗血症 コアグラーゼ陰性ブドウ球菌 5-7日
黄色ブドウ球菌 28日(14日)
グラム陰性桿菌 14日(7-14日)
カンジダ 血液培養陰性化後, 14日



  • Antibiotics to avoid in pregnancy
  • Sulfonamides––kernicterus.
  • Aminoglycosides––ototoxicity.
  • Fluoroquinolones––cartilage damage.
  • Erythromycin––acute cholestatic hepatitis in mom
(and clarithromycin––embryotoxic).
  • Metronidazole––mutagenesis.
  • Tetracyclines––discolored teeth, inhibition of bone growth.
  • Ribavirin (antiviral)––teratogenic.
  • Griseofulvin (antifungal)––teratogenic.
  • Chloramphenicol––“gray baby.”
  • SAFE Moms Take Really Good Care.


  • βラクタム系
  • エリスロマイシン、アジスロマイシン


  • 抗菌薬インターネットブック




塩酸スペクチノマイシン spectinomycin hydrochloride











spectinomycin hydrochloride」

  [★] スペクチノマイシン