furosemide

フロセミド  

WordNet

  1. commonly used diuretic (trade name Lasix) used to treat hypertension and edema (同)Lasix

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/17 15:14:55」(JST)

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English Journal

  • Biorelevant solubility of poorly soluble drugs: Rivaroxaban, furosemide, papaverine and niflumic acid.
  • Takács-Novák K, Szőke V, Völgyi G, Horváth P, Ambrus R, Szabó-Révész P.SourceDepartment of Pharmaceutical Chemistry, Semmelweis University, H-1092 Hőgyes Endre street 9, Budapest, Hungary. Electronic address: novak.krisztina@pharma.semmelweis-univ.hu.
  • Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Sep;83:279-85. doi: 10.1016/j.jpba.2013.05.011. Epub 2013 May 18.
  • In this work the biorelevant solubility of four drugs representing different acid-base property, wide range of lipohilicity and low aqueous solubility was studied. The equilibrium solubility of rivaroxaban (non-ionizable), furosemide (acid), papaverine (base) and niflumic acid (ampholyte) was determ
  • PMID 23770783
  • Thorough investigation of the retention mechanisms and retention behavior of amides and sulfonamides on amino column in hydrophilic interaction liquid chromatography.
  • Jovanović M, Stojanović BJ.SourceUniversity of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Vojvode Stepe 450, Belgrade, Serbia.
  • Journal of chromatography. A.J Chromatogr A.2013 Aug 2;1301:27-37. doi: 10.1016/j.chroma.2013.05.034. Epub 2013 Jun 3.
  • In this paper detailed analysis of a mixture of four amides (tropicamide, nicotinamide, tiracetam, and piracetam) and six sulfonamides (sulfanilamide, sulfacetamide, sulfamethoxazole, sulfafurazole, furosemide, and bumetanide) on aminopropyl column in hydrophilic interaction chromatography (HILIC) w
  • PMID 23791449
  • Attenuation of lithium-induced natriuresis and kaliuresis in P2Y2 receptor knockout mice.
  • Zhang Y, Li L, Kohan DE, Ecelbarger CM, Kishore BK.SourceNephrology Research (151M VA SLC Health Care System, 500 Foothill Drive, Salt Lake City, UT 84148. BK.Kishore@hsc.utah.edu.
  • American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2013 Aug;305(3):F407-16. doi: 10.1152/ajprenal.00464.2012. Epub 2013 Jun 5.
  • Whole body knockout (KO) of the P2Y2 receptor (P2Y2R) results in enhanced vasopressin V2 receptor activity and increased renal Na(+) conservation. We hypothesized that P2Y2R KO mice would be less sensitive to lithium-induced natriuresis and kaliuresis due to attenuated downregulation of one or more
  • PMID 23739592

Japanese Journal

  • 慢性腎臓病患者における長時間作用型と短時間作用型ループ利尿薬の効果と安全性の検討
  • 駒田 敬則,吉田 泉,佐久間 由紀,森 穂波,雨宮 守正,中里 優一,田部井 薫
  • 自治医科大学紀要 33, 79-90, 2011-03-01
  • 現在ループ利尿薬を服用している血清Cr値1.5mg/dl以上の外来患者を対象とし,文書にて同意を得られた34名を対象とした。投与薬剤の順番をランダム化して,アゾセミドまたはフロセミドを,1-2ヶ月毎に交互に投与した。その結果,アゾセミド60mgとフロセミド40mgを同等力価と考えて交互に投与した場合,血圧,体重,尿量,尿中Na排泄量に差はなく,血液検査データ,尿中電解質などにも差は無かった。尿蛋白 …
  • NAID 110008506955
  • Inheritance of an Autosomal Recessive Disorder, Gitelmans Syndrome, Across Two Generations in One Family
  • Yagi Hiroki,Yahata Kensei,Usui Takeshi,Hasegawa Chinatsu,Seta Koichi,Sugawara Akira
  • Internal Medicine 50(11), 1211-1214, 2011
  • … Clinically, he was diagnosed as GS because of diuretic responsiveness to furosemide but not thiazide. …
  • NAID 130000770474

Related Links

Furosemide, like other loop diuretics, acts by inhibiting NKCC2, the luminal Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic ...
Furosemide is used to treat fluid build-up and swelling caused by congestive heart failure, liver cirrhosis, or kidney disease. Learn about side effects, interactions and indications. ... What are the possible side effects of furosemide ...


Related Pictures

Lasix (furosemide) - Anabolic Steroid Furosemide Tablets - Diuretics Furosemide (Generic to Lasix and Salix Product Images FurosemideFurosemide Sdv VialUsing Furosemide to Treat Heart or Kidney



★リンクテーブル★
リンク元利尿薬」「急性尿細管間質性腎炎」「フロセミド
拡張検索furosemide renography」「furosemide renogram」「furosemide loading test followed by walking

利尿薬」

  [★]

diuretic, diuretics
尿細管

適応

利尿薬の種類 (GOO.744)

  CATIONS ANIONS 尿酸 腎血液動態
Na+ K+ H+ Ca2+ Mg2+ Cl- HCO3- H2PO4- 急性 慢性 RBF GFR FF TGF
炭酸脱水酵素阻害薬 炭酸脱水酵素阻害 近位尿細管
 
++ NC V (+) ++ ++ I NC
浸透圧利尿薬 浸透圧 ヘンレループ
 
++ I ++ I NC I
ループ利尿薬 Na+-K+-2Cl- symport阻害 太い上行脚
 
++ ++ ++ ++ ++ (1) (1) V(+) NC V(-)
チアジド系利尿薬 Na+-Cl-symport阻害 遠位尿細管
 
++ V(-) V(+) (1) (1) NC V(-) V(-) NC
カリウム保持性利尿薬 上皮性ナトリウムチャネル阻害 遠位尿細管後部と集合管
 
(+) NC I NC NC NC NC
アルドステロン受容体拮抗 遠位尿細管後部と集合管
 
I (+) I I NC NC NC NC

利尿薬の例

  • 上皮性ナトリウムチャネル阻害薬
  • アルドステロン受容体阻害薬

利尿薬の作用部位

  • ホルモンと利尿薬の作用部位についての簡単なまとめは→尿細管

参照

http://hobab.fc2web.com/sub4-Diuretics.htm

急性尿細管間質性腎炎」

  [★]

acute tubulointerstitial nephritis
急性間質性腎炎 acute interstitial nephritis, AIN
尿細管間質性腎炎

原因

  • 薬剤性
  • 感染症
  • 特発性

フロセミド」

  [★]

furosemide
オイテンシンプロメデスラシックス Lasix、ラドンナ、ロープストン
利尿薬
  • first aid step1 2006 p.389,390

作用機序

薬理作用

  • 体液量の低下により抗高血圧作用を示す (SPC.253)

furosemide renography」

  [★] フロセミド負荷腎レノグラフィ

furosemide renogram」

  [★] フロセミド負荷レノグラム

furosemide loading test followed by walking」

  [★] 立位フロセミド負荷試験