WordNet

of critical importance and consequence; "an acute (or critical) lack of research funds"
having or demonstrating ability to recognize or draw fine distinctions; "an acute observer of politics and politicians"; "incisive comments"; "icy knifelike reasoning"; "as sharp and incisive as the stroke of a fang"; "penetrating insight"; "frequent penetrative observations" (同)discriminating, incisive, keen, knifelike, penetrating, penetrative, piercing, sharp
extremely sharp or intense; "acute pain"; "felt acute annoyance"; "intense itching and burning" (同)intense
having or experiencing a rapid onset and short but severe course; "acute appendicitis"; "the acute phase of the illness"; "acute patients"
of an angle; less than 90 degrees
an inflammation of the kidney (同)Bright''s disease

PrepTutorEJDIC

(先の)『鋭い』,とがった / (痛み・感情などが)『激しい』,強い / (知力・感覚などが)『鋭い』,鋭敏な / (事態が)重大な / (病気が)急性の / (音が)高い,鋭い / 鋭角の
腎炎(じんえん)

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1. 急性間質性腎炎の臨床症状および診断 clinical manifestations and diagnosis of acute interstitial nephritis
2. 急性間質性腎炎の治療 treatment of acute interstitial nephritis
3. 好酸球の生物学および好酸球増多症の原因 eosinophil biology and causes of eosinophilia
4. 尿細管間質性腎炎とブドウ膜炎（TINU症候群） tubulointerstitial nephritis and uveitis tinu syndrome
5. 尿中好酸球の意義 the significance of urinary eosinophils

Smoking is associated with aggravated kidney injury in Puumala hantavirus-induced haemorrhagic fever with renal syndrome.

Tervo L1, Mäkelä S2, Syrjänen J2, Huttunen R1, Rimpelä A3, Huhtala H4, Vapalahti O5, Vaheri A5, Mustonen J2.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.Nephrol Dial Transplant.2015 Jul 5. pii: gfv273. [Epub ahead of print]
BACKGROUND: Previous studies indicate that smoking affects the outcome of some infections and is a risk factor for Puumala virus (PUUV) infection. The aim of this study was to assess the effect of smoking on the clinical severity of PUUV infection and the prevalence of smoking in patients with PUUV
PMID 26150428

Renal Klotho expression in patients with acute kidney injury is associated with the severity of the injury.

Seo MY1, Yang J1, Lee JY1, Kim K1, Kim SC1, Chang H1, Won NH2, Kim MG1, Jo SK1, Cho W1, Kim HK1.
The Korean journal of internal medicine.Korean J Intern Med.2015 Jul;30(4):489-95. doi: 10.3904/kjim.2015.30.4.489. Epub 2015 Jun 29.
BACKGROUND/AIMS: The potential physiologic roles of Klotho in acute kidney injury (AKI) have recently been demonstrated in animal models. However, to date, there have been no human studies investigating the expression of renal Klotho in AKI.METHODS: We retrospectively collected biopsy specimens and
PMID 26161015

Valluri A1, Hetherington L1, Mcquarrie E1, Fleming S1, Kipgen D1, Geddes CC1, Mackinnon B1, Bell S2.
QJM : monthly journal of the Association of Physicians.QJM.2015 Jul;108(7):527-32. doi: 10.1093/qjmed/hcu236. Epub 2014 Nov 28.
BACKGROUND AND AIMS: Acute tubulointerstitial nephritis (ATIN) is a potentially reversible cause of acute kidney injury with the majority of cases drug related. Our aims were to examine the incidence profile of patients with ATIN in Scotland and to assess the impact of corticosteroid treatment.DESIG
PMID 25434050