WordNet
- impervious to being affected; "resistant to the effects of heat"; "resistant to persuasion"
PrepTutorEJDIC
- 抵抗力のある;(…に)抵抗する《+『to』+『名』》
UpToDate Contents
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- 1. ウィップル病 whipples disease
- 2. 成人における敗血症性関節炎 septic arthritis in adults
- 3. Trachoma
- 4. 成人における市中肺炎の治療に関する抗菌薬の研究 antibiotic studies for the treatment of community acquired pneumonia in adults
- 5. 入院を要する成人における市中肺炎の治療 treatment of community acquired pneumonia in adults who require hospitalization
English Journal
- Anti-mycobacterial activities of synthetic cationic α-helical peptides and their synergism with rifampicin.
- Khara JS1, Wang Y1, Ke XY2, Liu S2, Newton SM3, Langford PR3, Yang YY4, Ee PL5.Author information 1Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore.2Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore.3Section of Paediatrics, Division of Medicine, St Mary's Campus, Imperial College, London W2 1PG, United Kingdom.4Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore. Electronic address: yyyang@ibn.a-star.edu.sg.5Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore. Electronic address: phaeplr@nus.edu.sg.AbstractThe rapid emergence of multi-drug resistant tuberculosis (TB) and the lack of effective therapies have prompted the development of compounds with novel mechanisms of action to tackle this growing public health concern. In this study, a series of synthetic cationic α-helical antimicrobial peptides (AMPs) modified with different hydrophobic amino acids was investigated for their anti-mycobacterial activity, both alone and in synergistic combinations with the frontline anti-tuberculosis drug rifampicin. The addition of thiol groups by incorporating cysteine residues in the AMPs did not improve anti-mycobacterial activity against drug-susceptible and drug-resistant Mycobacterium tuberculosis, while the enhancement of peptide hydrophobicity by adding methionine residues increased the efficacy of the primary peptide against all strains tested, including clinically isolated multidrug-resistant mycobacteria. The peptide with the optimal composition M(LLKK)2M was bactericidal, and eradicated mycobacteria via a membrane-lytic mechanism as demonstrated by confocal microscopic studies. Mycobacteria did not develop resistance after multiple exposures to sub-lethal doses of the peptide. In addition, the peptide displayed synergism with rifampicin against both Mycobacterium smegmatis and Mycobacterium bovis BCG and additivity against M. tuberculosis. Moreover, such combination therapy is effective in delaying the emergence of rifampicin resistance. The ability to potentiate anti-TB drug activity, kill drug-resistant bacteria and prevent drug resistance highlights the potential utility of the peptide in combating multidrug-resistant TB.
- Biomaterials.Biomaterials.2014 Feb;35(6):2032-8. doi: 10.1016/j.biomaterials.2013.11.035. Epub 2013 Dec 4.
- The rapid emergence of multi-drug resistant tuberculosis (TB) and the lack of effective therapies have prompted the development of compounds with novel mechanisms of action to tackle this growing public health concern. In this study, a series of synthetic cationic α-helical antimicrobial peptides (
- PMID 24314557
- Enzymatic and bacterial conversions during sourdough fermentation.
- Gänzle MG.Author information University of Alberta, Department of Agricultural, Food and Nutritional Science, 4-10 Ag/For Centre, Edmonton, Canada T6G 2P5. Electronic address: mgaenzle@ualberta.ca.AbstractEnzymatic and microbial conversion of flour components during bread making determines bread quality. Metabolism of sourdough microbiota and the activity of cereal enzymes are interdependent. Acidification, oxygen consumption, and thiols accumulation by microbial metabolism modulate the activity of cereal enzymes. In turn, cereal enzymes provide substrates for bacterial growth. This review highlights the role of cereal enzymes and the metabolism of lactic acid bacteria in conversion of carbohydrates, proteins, phenolic compounds and lipids. Heterofermentative lactic acid bacteria prevailing in wheat and rye sourdoughs preferentially metabolise sucrose and maltose; the latter is released by cereal enzymes during fermentation. Sucrose supports formation of acetate by heterofermentative lactobacilli, and the formation of exopolysaccharides. The release of maltose and glucose by cereal enzymes during fermentation determines the exopolysaccharide yield in sourdough fermentations. Proteolysis is dependent on cereal proteases. Peptidase activities of sourdough lactic acid bacteria determine the accumulation of (bioactive) peptides, amino acids, and amino acid metabolites in dough and bread. Enzymatic conversion and microbial metabolism of phenolic compounds is relevant in sorghum and millet containing high levels of phenolic compounds. The presence of phenolic compounds with antimicrobial activity in sorghum selects for fermentation microbiota that are resistant to the phenolic compounds.
- Food microbiology.Food Microbiol.2014 Feb;37:2-10. doi: 10.1016/j.fm.2013.04.007. Epub 2013 Apr 25.
- Enzymatic and microbial conversion of flour components during bread making determines bread quality. Metabolism of sourdough microbiota and the activity of cereal enzymes are interdependent. Acidification, oxygen consumption, and thiols accumulation by microbial metabolism modulate the activity of c
- PMID 24230468
- Induction and transfer of resistance to poisoning by Amorimia (Mascagnia) septentrionalis in goats.
- Duarte AL, Medeiros RM, Carvalho FK, Lee ST, Cook D, Pfister JA, Costa VM, Riet-Correa F.Author information Veterinary Hospital, CSTR, Federal University of Campina Grande (UFCG), Patos, Paraíba, 58700-000, Brazil.AbstractAmorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause acute heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non-toxic doses of A. septentrionalis. We also show that increased resistance to poisoning by A. septentrionalis can also be achieved by the transfaunation of ruminal content from goats previously conditioned to be resistant to naïve goats. These methods of improving resistance require further study, but appear to provide potential management solutions to mitigate toxicity problems from A. septentrionalis, and perhaps other plant species containing MFA. Copyright © 2013 John Wiley & Sons, Ltd.
- Journal of applied toxicology : JAT.J Appl Toxicol.2014 Feb;34(2):220-3. doi: 10.1002/jat.2860. Epub 2013 Feb 12.
- Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause acute heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non-toxic doses o
- PMID 23400835
Japanese Journal
- The effects of N-acylhomoserine lactones, β-lactam antibiotics and adenosine on biofilm formation in the multi-β-lactam antibiotic-resistant bacterium Acidovorax sp. strain MR-S7
- Kusada Hiroyuki,Hanada Satoshi,Kamagata Yoichi [他]
- Journal of bioscience and bioengineering 118(1), 14-19, 2014-07
- NAID 40020130040
- Isolation of a selenite-reducing and cadmium-resistant bacterium Pseudomonas sp. strain RB for microbial synthesis of CdSe nanoparticles
- Ayano Hiroyuki,Miyake Masaki,Terasawa Kanako [他]
- Journal of bioscience and bioengineering 117(5), 576-581, 2014-05
- NAID 40020068629
- Isolation of a selenite-reducing and cadmium-resistant bacterium Pseudomonas sp. strain RB for microbial synthesis of CdSe nanoparticles(ENVIRONMENTAL BIOTECHNOLOGY)
- Ayano Hiroyuki,Miyake Masaki,Terasawa Kanako,Kuroda Masashi,Soda Satoshi,Sakaguchi Toshifumi,Ike Michihiko
- Journal of bioscience and bioengineering 117(5), 576-581, 2014-05
- … As a result of isolation operations, the bacterium that was the most responsible for synthesizing CdSe, named Pseudomonas sp. … This report is the first describing isolation of a selenite-reducing and cadmium-resistant bacterium. …
- NAID 110009823133
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- This suggests that if you introduce a wt sensitive gene into a resistant bacterium by any method, you would then have a streptomycin sensitive bacterium. You don’t even have to eliminate or alter the resident resistant gene rpsL ...
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★リンクテーブル★
| リンク元 | 「耐性菌」「resistant cell」「resistant bacteria」 |
| 関連記事 | 「resistant」「bacterium」 |
「耐性菌」
医療系の雑誌より(日経カデット11月？)
表1抗菌薬投与後に出現する可能性か高い耐性菌
| 系統 | 前投与抗菌薬 | 抗菌薬投与後に高頻度に検出される細菌 | |
| 自然耐性菌 | 獲得耐性菌 | ||
| ペニシリン系 | アンピシリン | Klebsiella pneumoniae | 大腸菌、黄色ブドウ球菌(MSSA、MRSA) |
| ピベラシリン | 緑膿菌 | ||
| セフエム系(第1・2世代) | セフアゾリン、セフォチアム | 緑膿菌、腸球菌 | 黄色ブドウ球菌(MRSA)、大腸菌 |
| セフエム系(第3世代) | セフ卜リアキソン | 腸球菌 | 黄色ブドウ球菌(MRSA)、緑膿菌、大腸菌 |
| セフタジジム | |||
| セフエビム | |||
| カルバペネム系 | メロペネム | Stenotrophomonas maltophilia | 黄色ブドウ球菌(MRSA)、緑膿菌 |
| イミペネム | |||
| アミノグリコシド系 | アミカシン | 腸球菌、嫌気性菌 | 緑膿菌, Serratia marcescens |
| トブラマイシン | レンサ球菌、肺炎球菌 | ||
| マクロライド系 | クラリスロマイシン | 腸内細菌科 | 黄色ブドウ球菌、肺炎球菌、化膿性レンサ球菌 |
| アジスロマシン | |||
| テトラサイクリン系 | ミノサイクリン | Proteus mirabilis | 黄色ブドウ球菌(MRSA)、Brukholderia cepacia、Acinetobacter baumannii |
| Morganella morganii | |||
| Providencia rettgeri | |||
| キノロン系 | レポフロキサシン | レンサ球菌 | 黄色ブドウ球菌(MRSA、大腸菌、緑膿菌 |
表2主な耐性菌と治療薬
| 主な耐性菌 | 治療薬 |
| 緑膿菌 | アズトレオナム+ブラマイシン、シプロフロキサシン(感性株)、(コリスチン) |
| メチシリン耐性黄色ブドウ球菌(MRSA) | バンコマイシン、テイコプラ二ン、アルベカシン、リネゾリド、(ST合剤、リファンピシン) |
| ESBLs産生大腸菌 | ドリペネム、メロペネム、イミペネム、アミカシン、ST合剤 |
| グルコース非発酵性グラム陰性桿菌 | ミノサイクリン、ピベラシリン、アンピシリン+スルバクタム、クロラムフェニコール、ST合剤、(コリスチン) |
| バンコマイシン耐性腸球菌 | テイコプラ二ン(VanB型)、リネゾリド、キヌプリスチン/ダルホプリスチン |
| （）は多分保険適用かないか、日本では未発売 | |
「resistant cell」
「resistant bacteria」
「resistant」
- adj.
- 抵抗性の、耐性の、抵抗する
「bacterium」
- ns.
- 関
- bacteria