HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.
Contents
1Serology
2Disease associations
3Genetic linkage
4References
Serology
DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles[1]
DRB1*
DR11
DR5
DR12
Sample
allele
%
%
%
size (N)
1101
92
5
3474
1102
89
3
430
1103
89
4
397
1104
87
4
2119
1105
75
4
1106
20
73
15
1107
>50
1
1108
>50
2
1109
80
20
5
.
DR12
DR5
DR11
Sample
1201
83
4
2
893 [2]
1202
89
162
1203
>50
3
1206
>50
2
With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.
Disease associations
DR5 is associated with persistent generalized lymphadenopathy (PGL)[3] and Kaposi sarcoma in AIDS,[4] juvenile rheumatoid arthritis,[5][6] pernicious anemia, Hashimoto's thyroiditis,[7][8] mycosis fungoides,[9] polyglandular deficiency syndrome,[10] systemic sclerosis,[11][12] childhood epilepsy,[13] early-onset alopecia areata,[14] short-ragweed Ra6 allergy,[15] primary antiphospholipid syndrome,[16] and increased longevity in the Dutch[17]
Genetic linkage
HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).
References
^derived from IMGT/HLA
^DR8 - 2%
^Raffoux C, David V, Couderc L, Rabian C, Clauvel J, Seligmann M, Colombani J (1987). "HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia". Tissue Antigens. 29 (1): 60–2. doi:10.1111/j.1399-0039.1987.tb01550.x. PMID 3495904.
^Pollack M, Safai B, Myskowski P, Gold J, Pandey J, Dupont B (1983). "Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma". Tissue Antigens. 21 (1): 1–8. doi:10.1111/j.1399-0039.1983.tb00364.x. PMID 6601312.
^Førre O, Dobloug J, Høyeraal H, Thorsby E (1983). "HLA antigens in juvenile arthritis. Genetic basis for the different subtypes". Arthritis Rheum. 26 (1): 35–8. doi:10.1002/art.1780260106. PMID 6401993.
^Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C (1980). "HLA-DR5 in juvenile rheumatoid arthritis confined to few joints". Lancet. 2 (8184): 40. doi:10.1016/S0140-6736(80)92920-7. PMID 6104257.
^Farid N, Sampson L, Moens H, Barnard J (1981). "The association of goitrous autoimmune thyroiditis with HLA-DR5". Tissue Antigens. 17 (3): 265–8. doi:10.1111/j.1399-0039.1981.tb00700.x. PMID 6947505.
^Schleusener H, Schernthaner G, Mayr W, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K (1983). "HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter". J Clin Endocrinol Metab. 56 (4): 781–5. doi:10.1210/jcem-56-4-781. PMID 6131902.
^Safai B, Myskowski P, Dupont B, Pollack M (1983). "Association of HLA-DR5 with mycosis fungoides". J Invest Dermatol. 80 (5): 395–7. doi:10.1111/1523-1747.ep12553615. PMID 6601679.
^Shapiro M, Zamir R, Weiss E, Radnay J, Shenkman L (1987). "The polyglandular deficiency syndrome: a new variant in Persian Jews". J Endocrinol Invest. 10 (1): 1–7. doi:10.1007/bf03347139. PMID 3496374.
^Pereira S, Black C, Welsh K, Ansell B, Jayson M, Maddison P, Rowell N (1987). "Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families". J Rheumatol. 14 (4): 760–5. PMID 3499513.
^Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E (1987). "Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles". Arch Dermatol. 123 (9): 1188–91. doi:10.1001/archderm.123.9.1188. PMID 3498440.
^Minev M, Martinova F, Belopitova L (1987). "On the association of the HLA system with epilepsy in children". Epilepsia. 28 (1): 74–6. doi:10.1111/j.1528-1157.1987.tb03626.x. PMID 3098558.
^Orecchia G, Belvedere M, Martinetti M, Capelli E, Rabbiosi G (1987). "Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata". Dermatologica. 175 (1): 10–4. doi:10.1159/000248775. PMID 3497062.
^Marsh D, Freidhoff L, Ehrlich-Kautzky E, Bias W, Roebber M (1987). "Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans". Immunogenetics. 26 (4–5): 230–6. doi:10.1007/BF00346517. PMID 3498688.
^Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D (1995). "Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients". Arthritis Rheum. 38 (9): 1340–1. doi:10.1002/art.1780380925. PMID 7575732.
^Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van Rood J, Hijmans W (1991). "Longevity and heredity in humans. Association with the human leucocyte antigen phenotype". Ann N Y Acad Sci. 621: 78–89. doi:10.1111/j.1749-6632.1991.tb16970.x. PMID 1859103.
v
t
e
HLA DR
Genetic loci
HLA-DRA
HLA-DRB1
HLA-DRB3
HLA-DRB4
HLA-DRB5
HLA-DR
DRB1 Serotypes
DR1
DR2
DR3
DR4
DR5
DR6
DR7
DR8
DR9
DR10
DR11
DR12
DR13
DR14
DR15
DR16
DR17
DR18
Serotype of DRB3
DR52
Serotype of DRB4
DR53
Serotype of DRB5
DR51
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