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the 4th letter of the Roman alphabet (同)d
the 8th letter of the Roman alphabet (同)h

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/19 23:22:13」(JST)

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major histocompatibility complex, class II, DR3
Haplotypes groups	DRA01:DRB10301 DRA01:DRB10302 DRA01:DRB10303 DRA01:DRB10304
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA
EBI-HLA	DRA*0101
Identifiers	beta 1 0301 0301 0302 0303 *0304
Symbol(s)	HLA-DRB1
EBI-HLA	DRB1*0301
EBI-HLA	DRB1*0302
EBI-HLA	DRB1*0303
EBI-HLA	DRB1*0304
EBI-HLA	DRB1*0305
Shared data
Locus	chr.6 6p21.31

HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4.

Serology

DR17 and DR3 recognition of some DRB1*03 alleles^[1]
DRB1*	DR3	DR17	DR18	Sample
allele	%	%	%	size (N)
0301	33	64	0	9698
0302	24	3	66	317
0303	40		60	5
0304	60	20		5
0307	>50			1

Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, *0308 to *0331 are unknown.

Disease associations

By serotype

HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimoto's thyroiditis (along with DR5), primary sclerosing cholangitis,^[2] and opportunistic infections in AIDS,^[3] but lowered risk for cancers.^[4]

By allele

DRB1*0301 (see HLA-DR17)

DRB1*0302 (See HLA-DR18)

DRB1*0304 is associated with graves disease^[5]

By haplotypes

DR3 and/or DQ2 is associated with Moreen's ulceration,^[6] "bout onset" multiple sclerosis,^[7] Grave's disease^[8] and systemic lupus erythematosus^[9]

DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, Diabetes mellitus type 1. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*0501 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however is older studies DQA1*0505 is commonly confused with DQA1*0501)
^[10]

Genetic linkage

DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5).

References

^ derived from IMGT/HLA
^ Wiencke K, Karlsen TH, Boberg KM, et al. (2007). "Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes". Tissue Antigens 69 (2): 161–9. doi:10.1111/j.1399-0039.2006.00738.x. PMID 17257319.
^ Pollack MS, Gold J, Metroka CE, Safai B, Dupont B (1984). "HLA-A,B,C and DR antigen frequencies in acquired immunodeficiency syndrome (AIDS) patients with opportunistic infections". Hum. Immunol. 11 (2): 99–103. doi:10.1016/0198-8859(84)90048-X. PMID 6333416.
^ Mann DL, Murray C, O'Donnell M, Blattner WA, Goedert JJ (1990). "HLA antigen frequencies in HIV-1-related Kaposi's sarcoma". J. Acquir. Immune Defic. Syndr. 3 Suppl 1: S51–5. PMID 2395088.
^ Heward, Jm; Allahabadia, A; Sheppard, Mc; Barnett, Ah; Franklyn, Ja; Gough, Sc (Jul 1999). "Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501". Clinical endocrinology 51 (1): 115–8. doi:10.1046/j.1365-2265.1999.00755.x. ISSN 0300-0664. PMID 10468973.
^ Taylor C, Smith S, Morgan C, Stephenson S, Key T, Srinivasan M, Cunningham E, Watson P (2000). "HLA and Mooren's ulceration". Br J Ophthalmol 84 (1): 72–5. doi:10.1136/bjo.84.1.72. PMC 1723219. PMID 10611103.
^ Weinshenker B, Santrach P, Bissonet A, McDonnell S, Schaid D, Moore S, Rodriguez M (1998). "Major histocompatibility complex class II alleles and the course and outcome of MS: a population-based study". Neurology 51 (3): 742–7. doi:10.1212/wnl.51.3.742. PMID 9748020.
^ Ratanachaiyavong S, Lloyd L, Darke C, McGregor A (1993). "MHC-extended haplotypes in families of patients with Graves' disease". Hum Immunol 36 (2): 99–111. doi:10.1016/0198-8859(93)90112-E. PMID 8096501.
^ Tjernström F, Hellmer G, Nived O, Truedsson L, Sturfelt G (1999). "Synergetic effect between interleukin-1 receptor antagonist allele (IL1RN*2) and MHC class II (DR17,DQ2) in determining susceptibility to systemic lupus erythematosus". Lupus 8 (2): 103–8. doi:10.1191/096120399678847560. PMID 10192503.
^ Pera C, Delfino L, Longo A, Pistillo MP, Ferrara GB (March 2000). "Novel associations among HLA-DQA1 and -DQB1 alleles, revealed by high-resolution sequence-based typing (SBT)". Tissue Antigens 55 (3): 275–9. doi:10.1034/j.1399-0039.2000.550313.x. PMID 10777105.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. Autoimmune hepatitis: Pathogenesis
2. 原発性硬化性胆管炎：疫学および病因 primary sclerosing cholangitis epidemiology and pathogenesis
3. リウマチ性疾患への金化合物の使用 use of gold compounds in rheumatic diseases
4. サルコイドーシスの病因 pathogenesis of sarcoidosis
5. 金治療の主な副作用 major side effects of gold therapy

English Journal

Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax.

Storti-Melo LM, da Costa DR, Souza-Neiras WC, Cassiano GC, Couto VS, Póvoa MM, Soares Ida S, de Carvalho LH, Arevalo-Herrera M, Herrera S, Rossit AR, Cordeiro JA, de Mattos LC, Machado RL.SourceDepartamento de Biociências, Campus Universitário Prof. Alberto Carvalho, Universidade Federal de Sergipe, Itabaiana, SE, Brazil. stortilu@yahoo.com.br
Acta tropica.Acta Trop.2012 Feb;121(2):152-5. Epub 2011 Nov 4.
We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-l
PMID 22107686

Antigen targeting to MHC class II with SMEZ-2 M1, a superantigen-based vaccine carrier.

Radcliff FJ, Loh JM, Ha B, Schuhbauer D, McCluskey J, Fraser JD.SourceSchool of Medical Sciences & Maurice Wilkins Centre for Molecular Biodiscovery, Private Bag 92019, University of Auckland, Auckland, New Zealand, 1142.
Clinical and vaccine immunology : CVI.Clin Vaccine Immunol.2012 Feb 1. [Epub ahead of print]
SMEZ-2 is a streptococcal superantigen that primarily stimulates human T cells bearing Vβ8 and mouse T cells bearing Vβ11. Mutagenesis of T cell receptor (TCR) binding residues (W75L.K182Q.D42C) produced a mutant called M1 that was >10(5)-fold less active towards human peripheral blood lymphocy
PMID 22301693

Japanese Journal

Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis

VERPOORT KN
Arthritis Rheum 52, 3058-3062, 2005
NAID 30013443587

Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the β cells of islets of Langerhans

RAJAGOPALAN Govindarajan,KUDVA Yogish C.,CHEN Lieping,WEN Li,DAVID Chella S.
International immunology 15(9), 1035-1044, 2003-09-01
NAID 10014354231

A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients

CUCCA F.
Nat. Genet. 19, 301, 1998
NAID 80010427465

Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and-DR4 alleles

MARROSU M. G.
Am. J. Hum. Genet. 61, 454, 1997
NAID 30031162021

Related Pictures

Medicowesome: HLA subtype associated diseases mnemonics SYSTEMIC LUPUS ERYTHEMATOSUS - ppt video online download HLA-DRB3 (gene) - Wikipedia Eine Autoimmunerkrankung kommt selten allein was tun wenn Diabetes und Co Hla-Dr3 Antigen HLA A1-B8-DR3-DQ2 Sistema HLA , complejo principal de histocompatibilidad - ppt descargar

★リンクテーブル★

リンク元	「ヒト白血球抗原」「疱疹状皮膚炎」
拡張検索	「HLA-DR3 antigen」
関連記事	「D」「HL」「DR」「H」「HLA」

「ヒト白血球抗原」

　　[★]

英: human leucocyte antigen, HLA
同: ヒト白血球型抗原、HLA抗原 HLA antigen、ヒト組織適合性白血球抗原 human histocompatibility leukocyteantigen; 主要組織適合抗原 MHC　←　免疫との関連はこちらを参照
関: 骨髄バンク、HLA抗原

疾患との関連

出典不明

強直性脊椎炎	B27
関節リウマチ	DR4
重症筋無力症	DR9,DQ3
尋常性天疱瘡	A26,DR4
バセドウ病	DR5
I型糖尿病(インスリン依存性糖尿病)	B54,DR4,DR9,DR53,DQ4
グレーブス病	DR5
ベーチェット病	B51
原田病	DR4,DR53
潰瘍性大腸炎	B52,DR2
クローン病	DR4,DQ3
高安病	B52,DR2,DQ1
バージャー病	B52,DR2,DQ1
ナルコレプシー	DR2

first aid step1 2006 p.191

HLA-B27	psoriasis, ankylosing spondylitis, inflammatory bowel disease, Reiter's syndrome.
HLA-B8	Graves' disease, celiac sprue.
HLA-DR2	multiple sclerosis, hay fever, SLE, Goodpasture's syndrome.
HLA-DR3	diabetes mellitus type 1.
HLA-DR4	rheumatoid arthritis, diabetes mellitus type 1.
HLA-DR5	pernicious anemia → B12 deficiency, Hashimoto's thyroiditis.
HLA-DR7	steroid-responsive nephrotic syndrome.