WordNet

an anthelmintic used to treat hookworm and pinworm and roundworm infestations
any of various small animals or insects that are pests; e.g. cockroaches or rats; "cereals must be protected from mice and other vermin"; "he examined the childs head for vermin"; "boys in the village have probably been shooting vermin"
an irritating or obnoxious person (同)varmint

PrepTutorEJDIC

害獣,害鳥,害虫 / 世を毒する者,ならず者

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/04/19 13:43:24」(JST)

wiki en

"MBZ" redirects here. For the automobile brand abbreviated as "MBZ", see Mercedes-Benz.

Mebendazole or MBZ is a benzimidazole drug developed by Janssen Pharmaceutica and marketed as Vermox, Ovex, Antiox, and Pripsen. It is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

Medical use

The drug is a highly effective broad spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, whipworm, threadworm, and hookworm. It is poorly absorbed and has no systemic effects.^{[citation needed]}

Mechanism

Mebendazole is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubes in their intestinal cells: thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths.

Dosage

Oral dosage for treatment of pinworms is 100 mg taken once. This regimen is repeated two weeks later if the infestation has not cleared up. Oral dosage for treatment of whipworm, common roundworm and hookworm is one 100-mg tablet morning and evening for 3 consecutive days. Dosage is the same for both adults and children.^[1]

Adverse effects

Mebendazole is relatively free of toxic side effects or adverse reactions, although patients may complain of transient abdominal pain, diarrhea, slight headache, fever, dizziness, exanthema, urticaria and angioedema.

Contraindications

Pregnancy

Mebendazole is contraindicated in pregnant women because it has been shown to be embryotoxic and teratogenic in experimental animals.

Drug interactions

Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine does not appreciably raise serum mebendazole, consistent with its poor systemic absorption.^[2]^[3]

Stevens–Johnson syndrome (toxic epidermal necrolysis) can occur when mebendazole is combined with high doses of metronidazole.^[4]

Oncologic treatment potential

Several studies show mebendazole exhibits a potent antitumor properties. MZ significantly inhibited cancer cell growth, migration and metastatic formation of adrenocortical carcinoma, both in vitro and in vivo.^[5] Treatment of lung cancer cell lines with MZ caused mitotic arrest, followed by apoptotic cell death with the feature of caspase activation and cytochrome c release.^[6] MZ induced a dose- and time-dependent apoptotic response in human lung cancer cell lines^[7], and apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.^[8]

Discontinuation in United States

The last manufacturer of mebendazole in the United States, Teva Pharmaceuticals, announced on October 7, 2011, that they have ceased manufacture of this product. As of December, 2011, it is no longer available from any manufacturer in the USA. No reason was given for this discontinuation.^[9]

References

^ "Mebendazole". Drugs.com. http://www.drugs.com/pro/mebendazole.html. Retrieved 2011-10-29.
^ "Drug Interactions". Medicine chest. http://www.medicinechestonline.co.uk/static/professional2/drug_interactions.htm. Retrieved 2008-05-06.
^ Luder, P. J.; Siffert, B.; Witassek, F.; Meister, F.; Bircher, J. (1986). "Treatment of hydatid disease with high oral doses of mebendazole. Long-term follow-up of plasma mebendazole levels and drug interactions". European journal of clinical pharmacology 31 (4): 443–448. PMID 3816925. edit
^ Chen, K. T.; Twu, S. J.; Chang, H. J.; Lin, R. S. (2003). "Outbreak of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated with Mebendazole and Metronidazole Use Among Filipino Laborers in Taiwan". American journal of public health 93 (3): 489–492. PMC 1447769. PMID 12604501. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1447769. edit
^ http://www.deepdyve.com/lp/springer-journals/mebendazole-inhibits-growth-of-human-adrenocortical-carcinoma-cell-fiwfcO27hp
^ http://mct.aacrjournals.org/content/1/13/1201.abstract
^ http://clincancerres.aacrjournals.org/content/8/9/2963.abstract
^ http://mcr.aacrjournals.org/content/6/8/1308.abstract
^ "Drug Shortages Bulletin 750". American Society of Health-System Pharmacists. http://www.ashp.org/DrugShortages/Current/bulletin.aspx?id=750. Retrieved 12/18/2011.

External links

Vermox (UK manufacturer's website)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ジアルジア症の治療および予防 treatment and prevention of giardiasis
2. 蟯虫症および鞭虫症 enterobiasis pinworm and trichuriasis whipworm
3. 駆虫薬療法 anthelminthic therapies
4. エキノコックス症の治療および予防 treatment of echinococcosis
5. 集団寄生虫駆除 population deworming

English Journal

Helminth infection does not reduce risk for chronic inflammatory disease in a population-based cohort study.

Bager P, Vinkel Hansen A, Wohlfahrt J, Melbye M.SourceStatens Serum Institut, Department of Epidemiology Research, Copenhagen S, Denmark.
Gastroenterology.Gastroenterology.2012 Jan;142(1):55-62. Epub 2011 Oct 6.
BACKGROUND & AIMS: Parasitic helminth infections can suppress symptoms of allergy, type 1 diabetes, arthritis, and inflammatory bowel disease in animal models. We analyzed data from a large, population-based cohort study to determine whether common childhood enterobiasis protects against the
PMID 21983081

Efficacy of Lasia spinosa leaf extract in treating mice infected with Trichinella spiralis.

Yadav AK, Temjenmongla.SourceDepartment of Zoology, North-Eastern Hill University, Shillong, 793 022, India, akynehu@hotmail.com.
Parasitology research.Parasitol Res.2012 Jan;110(1):493-8. Epub 2011 Jul 12.
Trichinellosis is a widespread zoonoses for which no effective drug treatment is available at this time. Though anthelmintics such as mebendazole and albendazole are commonly used to treat human trichinellosis, none of these drugs are fully effective against the encysted or new-born larvae of Trichi
PMID 21748345

Low Efficacy of Single-Dose Albendazole and Mebendazole against Hookworm and Effect on Concomitant Helminth Infection in Lao PDR.

Soukhathammavong PA, Sayasone S, Phongluxa K, Xayaseng V, Utzinger J, Vounatsou P, Hatz C, Akkhavong K, Keiser J, Odermatt P.SourceNational Institute of Public Health, Ministry of Health, Vientiane, Lao People's Democratic Republic.
PLoS neglected tropical diseases.PLoS Negl Trop Dis.2012 Jan;6(1):e1417. Epub 2012 Jan 3.
BACKGROUND: Albendazole and mebendazole are increasingly deployed for preventive chemotherapy targeting soil-transmitted helminth (STH) infections. We assessed the efficacy of single oral doses of albendazole (400 mg) and mebendazole (500 mg) for the treatment of hookworm infection in school-aged ch
PMID 22235353

Japanese Journal

Efficacy of levamisole alone and in combination with mebendazole against <i>Gongylonema pulchrum</i> infection in rabbits

Journal of Veterinary Medical Science 77(1), 113-116, 2015
NAID 130004781017

Efficacy of levamisole alone and in combination with mebendazole against <i>Gongylonema pulchrum</i> infection in rabbits

Journal of Veterinary Medical Science, 2014
NAID 130004693910

Solubility Behavior and Prediction for Antihelmintics at Several Temperatures in Aqueous and Nonaqueous Mixtures

Chemical and Pharmaceutical Bulletin 58(5), 644-649, 2010
NAID 130000255822

Related Pictures

★リンクテーブル★

リンク元	「蠕虫」「駆虫薬」「メベンダゾール」「vermin」

「蠕虫」

Mebendazole
Systematic (IUPAC) name
	methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682315
Pregnancy cat.	C
Legal status	?
Routes	Oral
Pharmacokinetic data
Bioavailability	~2%
Metabolism	Hepatic
Half-life	2.5 to 5.5 hours
Identifiers
CAS number	31431-39-7
ATC code	P02CA01 QP52AC09
PubChem	CID 4030
DrugBank	DB00643
ChemSpider	3890
UNII	81G6I5V05I
KEGG	D00368
ChEBI	CHEBI:6704
ChEMBL	CHEMBL685
Chemical data
Formula	C16H13N3O3
Mol. mass	295.293 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21) ; Key:OPXLLQIJSORQAM-UHFFFAOYSA-N ;
Physical data
Melt. point	288.5 °C (551 °F)
(what is this?) (verify);

　　[★]

英: helminth, worms
ラ: helminthen
関: 微生物学、蠕虫症、家畜伝染病予防法

蠕虫類

吸虫類 trematoda
条虫類 cestoda
線虫類 nematoda
鉤頭虫類 acanthocephala

蠕虫類と感染症

蠕虫類	病原体名		病名	感染経路	寄生部位	症状	診断	治療
線虫類	Ancylostoma duodenale	ズビニ鉤虫	鈎虫症/十二指腸虫症	F型幼虫経口感染、経皮	空腸上部	皮膚炎、若菜病、貧血	飽和食塩水浮遊法、遠心沈降法	pyrantel pamoate、鉄剤
	Necator americanus	アメリカ鉤虫	鈎虫症/十二指腸虫症	F型幼虫経口感染、経皮	空腸上部	皮膚炎、若菜病、貧血	飽和食塩水浮遊法、遠心沈降法	pyrantel pamoate、鉄剤
	Strongyloides stercoralis	糞線虫	糞線虫症	F型幼虫経皮感染	小腸上部	Loffler症候群	糞便塗沫、普通寒天平板培養による R型、F型幼虫の検出	thiabendazole, ivermectin
	Enterobius vermicularis	蟯虫	蟯虫症	虫卵経口感染	盲腸～大腸	夜間の掻痒、不眠、情緒不安定	肛囲検査法「柿の種」	pyrantel pamoate
	Ascaris lumbricoides	回虫	回虫症	虫卵経口感染	小腸孵化→門脈→ 肺発育→食道嚥下→小腸	Loffler症候群。急性腹痛	糞便虫の虫卵の証明	pyrantel pamoate
	Toxocara canis	イヌ回虫	幼虫移行症	生後1-2ヶ月の感染犬の糞から経口感染	なし	幼虫移行症→失明	免疫診断	治療法無し？
	Wuchereria bancrofti	バンクロフト糸状虫	フィラリア症/糸状虫症	アカイエカ	リンパ系	急性期：リンパ肝炎、リンパ腺炎を伴う熱発作(filarial fever) 慢性期：乳糜尿、リンパ管瘤、陰嚢水腫、象皮病	急性期：夜間のmicrofilariaの検出慢性期：特有の症状を考慮	diethylcarbamazine & ivermectin
	Brugia malayi	マレー糸状虫	フィラリア症/糸状虫症	アカイエカ	リンパ系		急性期：夜間のmicrofilariaの検出慢性期：特有の症状を考慮	diethylcarbamazine & ivermectin
	Dirofilaria immitis	イヌ糸状虫		アカイエカ	なし	幼虫移行症→肺血管閉塞→胸部X線画像銭形陰影
	Gnathostoma spinigerum	有棘顎口虫	顎口虫症	ドジョウ、雷魚、ヘビの生食		消化管壁貫通→皮下移動による腫瘤や線状皮膚炎	移動性腫瘤、皮膚爬行疹雷魚やドジョウの生殖の問診免疫血清診断	なし
	Gnathostoma hispidum	剛棘顎口虫
	Gnathostoma doloresi	ドロレス顎口虫
	Gnathostoma nipponicum	日本顎口虫
	Anisakis simplex, larva	アニキサス幼虫	アニサキス症 (1)胃アニサキス症、 (2)腸アニサキス症、 (3)異所性アニサキス症	経口感染終宿主：クジラ、イルカ。中間宿主：オキアミ。待機宿主：サバ、ニシン、アジ、タラなど	胃や腸	(1)急激な上腹部痛"胃けいれん" (2)腹痛、急性虫垂炎、イレウス様。劇症型と緩和型がある (3)腹腔内の炎症性肉芽腫	胃内視鏡検査	内視鏡による虫体摘出
	Pseudoterranova decipiens	アニキサス幼虫	アニサキス症 (1)胃アニサキス症、 (2)腸アニサキス症、 (3)異所性アニサキス症	経口感染終宿主：クジラ、イルカ。中間宿主：オキアミ。待機宿主：サバ、ニシン、アジ、タラなど	胃や腸		胃内視鏡検査	内視鏡による虫体摘出
	Trichinella spiralis	旋毛虫	旋毛虫症	経口感染豚肉、クマ肉の生食		(1)成虫侵襲期：下痢、腹痛 (2)幼虫筋肉移行期：顔面浮腫、心筋障害など (3)幼虫被嚢期：全身浮腫、衰弱		急性期：ステロイド殺虫：mebendazole
			鞭虫症		盲腸	慢性下痢、腹痛、異食症、貧血	セロファン重層塗沫法、ホルマリンエーテル法	mebendazole
	Spirurin nematode larva	旋尾線虫	旋尾線虫幼虫	ホタルイカの生食	なし	皮膚爬行疹、イレウス様症状	予防：-30℃24時間。生食には-30℃4日間以上	摘出
吸虫類	Shistosoma japonicum	日本住血吸虫	日本住血吸虫症	糞便虫の虫卵→ミラシジウム→ ミヤイリガイ体内でセルカリア→ 人畜の皮膚より浸入→循環系→ 門脈に寄生	門脈	(1)潜伏期：侵入部の掻痒性皮膚炎。肺移行期：咳、発熱 (2)急性期：虫卵の門脈系寄生、産卵。住血吸虫性赤痢。 (3)慢性期：虫卵の肝、脳などの塞栓。肝硬変。脾腫、腹水	糞便虫の虫卵の検出。直腸粘膜層掻爬法、肝穿刺による組織内虫卵の検出。補助診断として免疫血清学的検査。	praziquantel
	Paragonimus westermani	ウェステルマン肺吸虫	肺吸虫症/肺ジストマ症	経口感染淡水産のカニ、イノシシ肉の生食	肺	痰、咳、胸痛、時に喀血	痰や便の虫卵検査、胸部写真、断層写真で明らかな虫嚢。免疫学血清検査
	Paragonimus miyazakii	宮崎肺吸虫	肺吸虫症/肺ジストマ症	経口感染淡水産のカニ、イノシシ肉の生食	肺	気胸、胸水貯留、膿胸、好酸球増加		praziquantel
	Clonorchis sinensis	肝吸虫	肝吸虫症/肝ジストマ症	経口感染虫卵→(マメタニシ:セルカリア)→ セルカリア→(魚:メタセルカリア)→ 摂取→(ヒト:成虫)→虫卵	胆管	胆汁流出障害による肝障害→肝硬変	糞便、胆汁(十二指腸ゾンデ法)。肝吸虫卵の検出。CT像。エコー検査。	praziquantel
			横川吸虫症	淡水魚(アユ、フナ、ウグイ、シラウオ)の生食	小腸粘膜	下痢、腹痛	糞便虫の虫卵	praziquantel
条虫類	Taeniarhynchus saginatus	無鉤条虫	腸管条虫症	経口感染。中間宿主：ウシ	小腸	無症状。下痢。広節裂頭条虫感染では悪性貧血。	糞便虫の虫卵と体節により診断	praziquantel。有鉤条虫の場合はガストログラフィン。有鉤条虫の駆虫の際、虫体を破壊しない →虫体の融解による嚢虫症
	Taenia solium	有鉤条虫		経口感染。中間宿主：ブタ
	Diphyllobothrium latum	広節裂頭条虫		経口感染。中間宿主：サケ、マス
		日本海裂頭条虫		経口感染。中間宿主：サケ
			腸管外条虫症
			有鉤嚢虫症	有鉤条虫の虫卵の経口摂取	皮下、筋肉内脳、脊髄、眼球	皮下、筋肉内：小指頭大の無症状腫瘤脳、脊髄、眼球：Jacksonてんかん。痙性麻痺など	皮下の虫嚢	外科的摘出。成虫寄生がなければ、praziquantel, albendazole + ステロイド
	Echinococcus granulosus	単包虫	包虫症/ エキノコックス症 (単包虫症)	終宿主：イヌ、キツネなど。中間宿主：ヒト、ブタ、野ネズミなど。終宿主の糞便虫の虫卵を中間宿主が接種して発症	肝、肺、まれに脳、腎、筋肉	肝寄生：肝部疼痛、満腹、時に黄疸、下肢浮腫肺寄生：胸部圧迫感、胸痛、咳、血痰、時に喀血	肝や肺の嚢胞形成から疑う。早期に診断に皮内反応→ CT、エコー→ 生検。免疫血清学的診断法	外科的切除。 albendazoleの長期投与
	Echinococcus multilocularis	多包虫	包虫症/ エキノコックス症 (多包虫症)	終宿主：イヌ、キツネなど。中間宿主：ヒト、ブタ、野ネズミなど。終宿主の糞便虫の虫卵を中間宿主が接種して発症	肝、肺、まれに脳、腎、筋肉	肝寄生：肝部疼痛、満腹、時に黄疸、下肢浮腫肺寄生：胸部圧迫感、胸痛、咳、血痰、時に喀血	肝や肺の嚢胞形成から疑う。早期に診断に皮内反応→ CT、エコー→ 生検。免疫血清学的診断法	外科的切除。 albendazoleの長期投与

「駆虫薬」

　　[★]

英: anthelmintic, anthelmintics
ラ: anthelmintica
関

http://en.wikipedia.org/wiki/Anthelmintic

antiplatyhelmintic agents	Antitrematodals (schistosomicides)	binds tubulin	benzimidazole (Triclabendazole#)
		acetylcholinesterase inhibitor	phosphonic acid (metrifonate)
		Other/unknown	quinoline (praziquantel#, oxamniquine#) · phenol (bithionol) · thiazole ([[niridazole]) · arylsulfonate (stibophen)
	anticestodals (taeniacides)	binds tubulin	benzimidazole (albendazole#)
	anticestodals (taeniacides)	Other/unknown	salicylanilide (niclosamide)# · aminoacridine (quinacrine) · butyrophenone (desaspidin) · chlorophenol (dichlorophen)
antinematodal agents (macrofilaricides)		binds tubulin	benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ciclobendazole, flubendazole)
		chloride channel	macrolide (ivermectin#)
		NMDA	tetrahydropyrimidine (pyrantel#, pyrantel pamoate, oxantel)
		Other/unknown	piperazine (piperazine · diethylcarbamazine#) · thiazole (levamisole#) · quinolinium (pyrvinium) · benzylammonium (bephenium) · naphthalenesulfonate (suramin#) · tribendimidine

「メベンダゾール」

　　[★]

英: mebendazole
商: VERMOX
関: 害虫

参考文献

メベンダゾール錠100

http://www.info.pmda.go.jp/go/pack/6429005F1026_1_06/6429005F1026_1_06?view=body

「vermin」

　　[★]

n.

寄生虫、寄生動物、害虫

関: insect pest、mebendazole、noxious insect、parasite、parasitic、parasitic worm、pest、worm

[drugs.com-0] "Mebendazole". Drugs.com. http://www.drugs.com/pro/mebendazole.html. Retrieved 2011-10-29.

[1] "Drug Interactions". Medicine chest. http://www.medicinechestonline.co.uk/static/professional2/drug_interactions.htm. Retrieved 2008-05-06.

[2] Luder, P. J.; Siffert, B.; Witassek, F.; Meister, F.; Bircher, J. (1986). "Treatment of hydatid disease with high oral doses of mebendazole. Long-term follow-up of plasma mebendazole levels and drug interactions". European journal of clinical pharmacology 31 (4): 443–448. PMID 3816925. edit

[pmid12604501-3] Chen, K. T.; Twu, S. J.; Chang, H. J.; Lin, R. S. (2003). "Outbreak of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Associated with Mebendazole and Metronidazole Use Among Filipino Laborers in Taiwan". American journal of public health 93 (3): 489–492. PMC 1447769. PMID 12604501. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1447769. edit

[4] ttp://www.deepdyve.com/lp/springer-journals/mebendazole-inhibits-growth-of-human-adrenocortical-carcinoma-cell-fiwfcO27hp

[5] ttp://mct.aacrjournals.org/content/1/13/1201.abstract

[6] ttp://clincancerres.aacrjournals.org/content/8/9/2963.abstract

[7] ttp://mcr.aacrjournals.org/content/6/8/1308.abstract

[8] "Drug Shortages Bulletin 750". American Society of Health-System Pharmacists. http://www.ashp.org/DrugShortages/Current/bulletin.aspx?id=750. Retrieved 12/18/2011.

匿名

検索

案内

案内

mebendazole