関: oxantel pamoate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/09 03:15:03」(JST)

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Oxantel is an anthelmintic. It has typically been used human and animal use as a standard treatment for intestinal worms.

Oxantel is currently^[when?] being experimented with for the treatment of periodontal disease by the Cooperative Research Centre for Oral Health Science (CRC). Professor Eric Reynolds (also the head of Dental School at the University of Melbourne, Australia) and his Associate Professor Stuart Dashper are currently testing its ability as a Fumarate reductase inhibitor.

Fumarate reductase is an enzyme that has been found in the pathogenic bacteria in the biofilm in periodontal pockets. This bacteria has the ability to convert blood components into energy and for the bacteria to be virulent. Such bacteria would starve without this enzyme. As such, the role of the Oxantel as a fumarate reductase inhibitor would be to kill the bacteria responsible for periodontal disease.

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1. 蟯虫症および鞭虫症 enterobiasis pinworm and trichuriasis whipworm
2. Mass drug administration for control of parasitic infections

English Journal

Oxantel pamoate and deworming programmes.

Maheu-Giroux M1.
The Lancet. Infectious diseases.Lancet Infect Dis.2015 Sep 17. pii: S1473-3099(15)00305-9. doi: 10.1016/S1473-3099(15)00305-9. [Epub ahead of print]
PMID 26388170

Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.

Moser W1, Ali SM2, Ame SM2, Speich B1, Puchkov M3, Huwyler J3, Albonico M4, Hattendorf J5, Keiser J6.
The Lancet. Infectious diseases.Lancet Infect Dis.2015 Sep 17. pii: S1473-3099(15)00271-6. doi: 10.1016/S1473-3099(15)00271-6. [Epub ahead of print]
BACKGROUND: Commonly used drugs for preventive chemotherapy against soil-transmitted helminths (ie, albendazole and mebendazole) show low efficacy against Trichuris trichiura. Recent studies with oxantel pamoate revealed good cure rates and high egg-reduction rates against T trichiura. We aimed to a
PMID 26388169

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised controlled trial.

Speich B1, Ali SM2, Ame SM2, Bogoch II3, Alles R4, Huwyler J4, Albonico M5, Hattendorf J6, Utzinger J6, Keiser J7.
The Lancet. Infectious diseases.Lancet Infect Dis.2015 Mar;15(3):277-84. doi: 10.1016/S1473-3099(14)71050-3. Epub 2015 Jan 12.
BACKGROUND: Existing anthelmintic drugs (eg, albendazole and mebendazole) have low efficacy against the intestinal nematode species Trichuris trichiura and the drug pipeline is exhausted. We aimed to investigate the strategy of combination chemotherapy with existing drugs to establish whether their
PMID 25589326

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★リンクテーブル★

リンク元	「駆虫薬」「オキサンテル」
拡張検索	「oxantel pamoate」

「駆虫薬」

Oxantel
Systematic (IUPAC) name
	3-[(E)-2-(1-Methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol
Identifiers
CAS Number	68813-55-8
ATC code	P02CC02 (WHO) QP52AF03
PubChem	CID 5281087
ChemSpider	4444540
UNII	94AJJ30D9E
KEGG	D00806
Chemical data
Formula	C13H16N2O
Molar mass	216.28 g/mol
	SMILES CN1CCCN=C1/C=C/C2=CC(=CC=C2)O ;
	InChI InChI=1S/C13H16N2O/c1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h2,4-7,10,16H,3,8-9H2,1H3/b7-6+ ; Key:VRYKTHBAWRESFI-VOTSOKGWSA-N ;
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英: anthelmintic, anthelmintics
ラ: anthelmintica
関

http://en.wikipedia.org/wiki/Anthelmintic

antiplatyhelmintic agents	Antitrematodals (schistosomicides)	binds tubulin	benzimidazole (Triclabendazole#)
		acetylcholinesterase inhibitor	phosphonic acid (metrifonate)
		Other/unknown	quinoline (praziquantel#, oxamniquine#) · phenol (bithionol) · thiazole ([[niridazole]) · arylsulfonate (stibophen)
	anticestodals (taeniacides)	binds tubulin	benzimidazole (albendazole#)
	anticestodals (taeniacides)	Other/unknown	salicylanilide (niclosamide)# · aminoacridine (quinacrine) · butyrophenone (desaspidin) · chlorophenol (dichlorophen)
antinematodal agents (macrofilaricides)		binds tubulin	benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ciclobendazole, flubendazole)
		chloride channel	macrolide (ivermectin#)
		NMDA	tetrahydropyrimidine (pyrantel#, pyrantel pamoate, oxantel)
		Other/unknown	piperazine (piperazine · diethylcarbamazine#) · thiazole (levamisole#) · quinolinium (pyrvinium) · benzylammonium (bephenium) · naphthalenesulfonate (suramin#) · tribendimidine