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Desaspidin is an anthelmintic. Desapidin may occur in natural form within some plants such as Coastal woodfern, Dryopteris arguta.^[1] Since the 1950s the inhibition effects of desapidins upon phosphorylation in chloroplasts has been noted and studied.^[2]

References

^ C. Michael Hogan. 2008. Coastal Woodfern (Dryopteris arguta}, GlobalTwitcher, ed. N. Stromberg
^ Bacon Kê. 2001. Photosynthesis: photobiochemistry and photobiophysics, Published by Springer, 763 pages ISBN 0-7923-6791-X, 9780792367918

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English Journal

In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms.

Magalhães LG1, Kapadia GJ, da Silva Tonuci LR, Caixeta SC, Parreira NA, Rodrigues V, Da Silva Filho AA.
Parasitology research.Parasitol Res.2010 Jan;106(2):395-401. doi: 10.1007/s00436-009-1674-8. Epub 2009 Nov 7.
The rhizomes of Dryopteris species have popularly been used as vermifuge in flatworm infections. The aim of this work was to evaluate the in vitro schistosomicidal activity of some phloroglucinol compounds, obtained from the rhizomes of Dryopteris species, against Schistosoma mansoni adult worms. Al
PMID 19898869

Anti-tumor promoting activity of Dryopteris phlorophenone derivatives.

Kapadia GJ1, Tokuda H, Konoshima T, Takasaki M, Takayasu J, Nishino H.
Cancer letters.Cancer Lett.1996 Aug 2;105(2):161-5.
As a part of screening studies for cancer chemopreventive agents (anti-tumor promoters) 33 Dryopteris phlorophenone derivatives have been evaluated. The compounds tested comprised of monomeric acylphloroglucinols (e.g. desaspidinol, aspidinol) as well as dimeric (e.g. aspidin, desaspidin), trimeric
PMID 8697439

Interaction of photosystem I-derived protons with the water-splitting enzyme complex. Evidence for localized domains.

Theg SM, Belanger KM, Dilley RA.
Journal of bioenergetics and biomembranes.J Bioenerg Biomembr.1987 Feb;19(1):53-68.
The induction of millisecond delayed fluorescence mediated by PS I-dependent proton pumping has been used as an indicator of the time course with which those protons equilibrate with sites on the oxygen-evolving enzyme complex (Bowes, J. M., and Crofts, A. R. (1978). Z. Naturforsch. 33C, 271-275). W
PMID 3032930

Japanese Journal

Photosystem I and photophosphorylation-dependent leucine incorporation in the blue-green alga Anacystis nidulans

Plant and cell physiology 20(7), 1179-1190, 1979-11
NAID 110003717733

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「駆虫薬」

Desaspidin
Systematic (IUPAC) name
	2-Butanoyl-4-[(3-butanoyl-2,4-dihydroxy-6-methoxyphenyl)methyl]-3,5-dihydroxy-6,6-dimethylcyclohexa-2,4-dien-1-one
Identifiers
CAS Registry Number	114-43-2
ATC code	P02DX01
PubChem	CID: 8238
ChemSpider	10295071
UNII	KV3495SGKS
KEGG	D07365
ChEMBL	CHEMBL2105606
Chemical data
Formula	C24H30O8
Molecular mass	446.49 g/mol
	SMILES CCCC(=O)C1=C(C(=C(C=C1O)OC)CC2=C(C(C(=C(C2=O)C(=O)CCC)O)(C)C)O)O ;
	InChI InChI=1S/C24H30O8/c1-6-8-14(25)18-16(27)11-17(32-5)12(20(18)28)10-13-21(29)19(15(26)9-7-2)23(31)24(3,4)22(13)30/h11,27-28,30-31H,6-10H2,1-5H3 ; Key:GAHOBHHMYUYJDT-UHFFFAOYSA-N ;
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英: anthelmintic, anthelmintics
ラ: anthelmintica
関

http://en.wikipedia.org/wiki/Anthelmintic

antiplatyhelmintic agents	Antitrematodals (schistosomicides)	binds tubulin	benzimidazole (Triclabendazole#)
		acetylcholinesterase inhibitor	phosphonic acid (metrifonate)
		Other/unknown	quinoline (praziquantel#, oxamniquine#) · phenol (bithionol) · thiazole ([[niridazole]) · arylsulfonate (stibophen)
	anticestodals (taeniacides)	binds tubulin	benzimidazole (albendazole#)
	anticestodals (taeniacides)	Other/unknown	salicylanilide (niclosamide)# · aminoacridine (quinacrine) · butyrophenone (desaspidin) · chlorophenol (dichlorophen)
antinematodal agents (macrofilaricides)		binds tubulin	benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ciclobendazole, flubendazole)
		chloride channel	macrolide (ivermectin#)
		NMDA	tetrahydropyrimidine (pyrantel#, pyrantel pamoate, oxantel)
		Other/unknown	piperazine (piperazine · diethylcarbamazine#) · thiazole (levamisole#) · quinolinium (pyrvinium) · benzylammonium (bephenium) · naphthalenesulfonate (suramin#) · tribendimidine

[1] C. Michael Hogan. 2008. Coastal Woodfern (Dryopteris arguta}, GlobalTwitcher, ed. N. Stromberg

[2] Bacon Kê. 2001. Photosynthesis: photobiochemistry and photobiophysics, Published by Springer, 763 pages ISBN 0-7923-6791-X, 9780792367918

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desaspidin