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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/31 15:43:42」(JST)
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Flubendazole
|
Systematic (IUPAC) name |
Methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Legal status |
? |
Identifiers |
CAS number |
31430-15-6 Y |
ATC code |
P02CA05 QP52AC12 |
PubChem |
CID 35802 |
UNII |
R8M46911LR N |
KEGG |
D04200 Y |
ChEMBL |
CHEMBL145946 N |
Chemical data |
Formula |
C16H12FN3O3 |
Mol. mass |
313.28 g/mol |
N (what is this?) (verify) |
Flubendazole is an anthelmintic. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are Flubenol, Biovermin, and Flumoxal.[1]
It is also available for human use to treat worm infections. It is available OTC (without prescription) in Europe.
References[edit]
- ^ US Patent 5824336 - Chewable flubendazole tablets for companion animals
Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)
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Antiplatyhelmintic agents |
Antitrematodals
(schistosomicides)
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Binds tubulin
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AI
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|
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Other/unknown
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- quinoline
- Praziquantel#
- Oxamniquine#
- phenol
- thiazole
- arylsulfonate
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|
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Anticestodals
(taeniacides)
|
Binds tubulin
|
|
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Other/unknown
|
- salicylanilide
- aminoacridine
- butyrophenone
- chlorophenol
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Antinematodal agents
(including
macrofilaricides) |
Binds tubulin
|
- benzimidazole
- Mebendazole#
- Albendazole#
- Thiabendazole
- Fenbendazole
- Ciclobendazole
- Flubendazole
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Glutamate-gated chloride channel, GABA receptor
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- avermectins
- Abamectin
- Doramectin
- Emamectin
- Ivermectin
- Selamectin
- milbemycins
- Moxidectin
- Milbemycin oxime
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|
NMDA
|
- tetrahydropyrimidine
- Pyrantel#
- Pyrantel pamoate
- Oxantel
|
|
Other/unknown
|
- piperazine
- Piperazine
- Diethylcarbamazine#
- thiazole
- quinolinium
- benzylammonium
- naphthalenesulfonate
- Tribendimidine
|
|
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Variation in growth and drug susceptibility among Giardia duodenalis assemblages A, B and E in axenic in vitro culture and in the gerbil model.
- Benere E, VAN Assche T, Cos P, Maes L.SourceLaboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, B-2020 Antwerp, Belgium.
- Parasitology.Parasitology.2011 Sep;138(11):1354-61. Epub 2011 Aug 8.
- SUMMARYThis study investigated the molecular and biological variation among different Giardia duodenalis assemblages. In vitro growth and susceptibility to albendazole, fenbendazole, flubendazole, metronidazole, tinidazole and furazolidone was studied for laboratory (AI: WB, AII: G1 and B: GS/M-83-H
- PMID 21819642
- Infection dynamics of Ascaridia galli in non-caged laying hens.
- Hoglund J, Jansson DS.SourceDepartment of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences (SLU), P.O. Box 7009, SE-750 07 Uppsala, Sweden.
- Veterinary parasitology.Vet Parasitol.2011 Aug 25;180(3-4):267-73. Epub 2011 Mar 31.
- The infection dynamics of Ascaridia galli in laying hens was investigated in six commercial non-caged flocks. Three flocks were managed in accordance with the regulations for organic production and had outdoor access, whereas three flocks were housed indoors in aviaries or traditional floor systems.
- PMID 21514056
Japanese Journal
- Flubendazole in cystic echinococcosis therapy : Pharmaco-parasitological evaluation in mice
- CEBALLOS Laura,ELISSONDO Maria,SANCHEZ BRUNI Sergio,DENEGRI Guillermo,ALVAREZ Luis,LANUSSE Carlos
- Parasitology international : official journal of the Japanese Society of Parasitology 58(4), 354-358, 2009-12-01
- NAID 10027670345
- Flubendazole interferes with a wide spectrum of cell homeostatic mechanisms in Echinococcus granulosus protoscoleces
- CUMINO Andrea C.,ELISSONDO Maria Celina,DENEGRI Guillermo M.
- Parasitology international : official journal of the Japanese Society of Parasitology 58(3), 270-277, 2009-09-01
- NAID 10027669771
Related Links
- Flubendazole is an anthelmintic. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used by veterinarians for protection against internal parasites and worms in dogs and cats. Other brand names are ...
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★リンクテーブル★
[★]
- 英
- anthelmintic, anthelmintics
- ラ
- anthelmintica
- 関