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- pyrvinium pamoate
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/05/03 14:21:15」(JST)
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Pyrvinium
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Systematic (IUPAC) name |
2-[(E)-2-(2,5-Dimethyl-1-phenylpyrrol-3-yl)ethenyl]-N,N,1-trimethylquinolin-1-ium-6-amine |
Clinical data |
AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
7187-62-4 |
ATC code |
P02CX01 |
PubChem |
CID 5281035 |
UNII |
6B9991FLU3 |
ChEMBL |
CHEMBL1201303 |
Chemical data |
Formula |
C26H28N3+ |
Mol. mass |
382.52 g/mol |
Pyrvinium is an anthelmintic; only effective for pinworms.
Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)
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Antiplatyhelmintic agents |
Antitrematodals
(schistosomicides)
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Binds tubulin
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AI
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Other/unknown
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- quinoline
- Praziquantel#
- Oxamniquine#
- phenol
- thiazole
- arylsulfonate
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Anticestodals
(taeniacides)
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Binds tubulin
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Other/unknown
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- salicylanilide
- aminoacridine
- butyrophenone
- chlorophenol
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Antinematodal agents
(including
macrofilaricides) |
Binds tubulin
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- benzimidazole
- Mebendazole#
- Albendazole#
- Thiabendazole
- Fenbendazole
- Ciclobendazole
- Flubendazole
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Glutamate-gated chloride channel, GABA receptor
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- avermectins
- Abamectin
- Doramectin
- Emamectin
- Ivermectin
- Selamectin
- milbemycins
- Moxidectin
- Milbemycin oxime
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NMDA
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- tetrahydropyrimidine
- Pyrantel#
- Pyrantel pamoate
- Oxantel
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Other/unknown
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- piperazine
- Piperazine
- Diethylcarbamazine#
- thiazole
- quinolinium
- benzylammonium
- naphthalenesulfonate
- Tribendimidine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Use of chemical genomics in assessment of the UPR.
- Saito S, Tomida A.SourceCancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
- Methods in enzymology.Methods Enzymol.2011;491:327-41.
- Glucose deprivation, one of the major physiological conditions in solid tumor, leads to activation of the unfolded protein response (UPR) in cancer cells. The UPR occurs through the transcriptional and translational regulatory mechanisms that improve the capacity of the endoplasmic reticulum (ER) to
- PMID 21329808
- Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling.
- Saraswati S, Alfaro MP, Thorne CA, Atkinson J, Lee E, Young PP.SourceDepartment of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
- PloS one.PLoS One.2010 Nov 29;5(11):e15521.
- Wnt signaling plays an important role in developmental and stem cell biology. To test the hypothesis that temporary inhibition of Wnt signaling will enhance granulation tissue and promote angiogenesis in tissue repair, we employed a recently characterized small molecule Wnt inhibitor. Pyrvinium is a
- PMID 21170416
Japanese Journal
- Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2, 5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation
- ESUMI Hiroyasu,LU Jie,KURASHIMA Yukiko,HANAOKA Tomoyuki
- Cancer science 95(8), 685-690, 2004-08-10
- NAID 10013570573
- Sex-related Different Efficacy of Chemotherapy on Human Strongyloidiasis in Okinawa, Japan
- 小林 潤,佐藤 良也,當眞 弘,田崎 力,高良 政弘,城間 祥行
- 寄生虫学雑誌 = Japanese journal of parasitology 45(5), 350-354, 1996-10-01
- NAID 10009009114
Related Links
- Pyrvinium. From Wikipedia, the free encyclopedia. Jump to: navigation, search. This article may need to be wikified to meet Wikipedia's ... Chemical data. Formula · C26H28N3+. Mol. mass, 382.52 g/mol. Pyrvinium is an anthelmintic. ...
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