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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/18 03:05:41」(JST)

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Bephenium hydroxynaphthoate (INN, trade names Alcopara, Alcopar, Befenium, Debefenium, Francin, Nemex) is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.^[1]^[2]

Bephenium is not FDA-approved and is not available in the United States.^[3]

References

^ Sweetman S (ed.) (2009). Martindale: The complete drug reference (36th ed.). London: Pharmaceutical Press. p. 143. ISBN 978-0-85369-840-1.
^ Jayewardene G, Ismail MM, Wijayaratnam Y (July 1960). "Bephenium hydroxynaphthoate in treatment of ascariasis". Br Med J 2 (5194): 268–71. doi:10.1136/bmj.2.5194.268. PMC 2097409. PMID 14406934.
^ Pham PA (March 19, 2009). "Bephenium hydroxynaphthoate". Point-of-Care Information Technology ABX Guide. Johns Hopkins University. Retrieved on March 25, 2011. Freely available with registration.

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

English Journal

In vitro levamisole selection pressure on larval stages of Haemonchus contortus over nine generations gives rise to drug resistance and target site gene expression changes specific to the early larval stages only.

Sarai RS1, Kopp SR2, Knox MR3, Coleman GT2, Kotze AC4.
Veterinary parasitology.Vet Parasitol.2015 Jun 30;211(1-2):45-53. doi: 10.1016/j.vetpar.2015.05.002. Epub 2015 May 8.
There is some evidence that resistance to levamisole and pyrantel in trichostrongylid nematodes is due to changes in the composition of nicotinic acetylcholine receptors (nAChRs) which represent the drug target site. Altered expression patterns of genes coding for nAChR subunits, as well as the pres
PMID 25983232

Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum.

Robertson AP1, Puttachary S1, Buxton SK1, Martin RJ1.
PLoS neglected tropical diseases.PLoS Negl Trop Dis.2015 Feb 13;9(2):e0003495. doi: 10.1371/journal.pntd.0003495. eCollection 2015.
The cholinergic class of anthelmintic drugs is used for the control of parasitic nematodes. One of this class of drugs, tribendimidine (a symmetrical diamidine derivative, of amidantel), was developed in China for use in humans in the mid-1980s. It has a broader-spectrum anthelmintic action against
PMID 25679515

Whole-cell patch-clamp recording of nicotinic acetylcholine receptors in adult Brugia malayi muscle.

Robertson AP1, Buxton SK, Martin RJ.
Parasitology international.Parasitol Int.2013 Dec;62(6):616-8. doi: 10.1016/j.parint.2013.03.008. Epub 2013 Apr 3.
Lymphatic filariasis is a debilitating disease caused by clade III parasites like Brugia malayi and Wuchereria bancrofti. Current recommended treatment regimen for this disease relies on albendazole, ivermectin and diethylcarbamazine, none of which targets the nicotinic acetylcholine receptors in th
PMID 23562945

Japanese Journal

A CASE OF ANCYLOSTOMIASIS DIAGNOSED BY DUODENOFIBERSCOPE

久野信義,春日井達造
日本消化器内視鏡学会雑誌 16(5), 617-619_1, 1974
… Bephenium hydroxynaphthoate (Alcopara) was given. …
NAID 130004250834

Bephenium hydroxynaphthoate(Alcopar)の鉤虫集団駆虫効果について-3-

内田昭夫 [他]
寄生虫学雑誌 13(6), ????, 1964-12
NAID 40017623690

1-Bromo-2-naphthol(オーミン顆粒)とBephenium hydroxynaphthoate(Alcopar)の鉤虫駆除効果比較試験

小宮義孝 [他]
寄生虫学雑誌 13(5), ????, 1964-10
NAID 40017623679

Related Pictures

★リンクテーブル★

リンク元	「駆虫薬」
拡張検索	「bephenium compound」

「駆虫薬」

Bephenium
Systematic (IUPAC) name
	N-benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxynaphthalene-2-carboxylate
Clinical data
Pregnancy; category	Undefined;
Routes of; administration	Oral
Pharmacokinetic data
Bioavailability	<1%
Excretion	Renal (negligible)
Identifiers
CAS Registry Number	7181-73-9 ; 3818-50-6 (hydroxynaphtoate)
ATC code	P02CX02
PubChem	CID: 19667
ChemSpider	18524
UNII	47RU9546DX
ChEMBL	CHEMBL1673148
Chemical data
Formula	C17H22NO+
Molecular mass	256.36 g/mol
	SMILES O(c1ccccc1)CC[N+](Cc2ccccc2)(C)C ;
	InChI InChI=1S/C17H22NO/c1-18(2,15-16-9-5-3-6-10-16)13-14-19-17-11-7-4-8-12-17/h3-12H,13-15H2,1-2H3/q+1 ; Key:AVWWVJUMXRXPNF-UHFFFAOYSA-N ;
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英: anthelmintic, anthelmintics
ラ: anthelmintica
関

http://en.wikipedia.org/wiki/Anthelmintic

antiplatyhelmintic agents	Antitrematodals (schistosomicides)	binds tubulin	benzimidazole (Triclabendazole#)
		acetylcholinesterase inhibitor	phosphonic acid (metrifonate)
		Other/unknown	quinoline (praziquantel#, oxamniquine#) · phenol (bithionol) · thiazole ([[niridazole]) · arylsulfonate (stibophen)
	anticestodals (taeniacides)	binds tubulin	benzimidazole (albendazole#)
	anticestodals (taeniacides)	Other/unknown	salicylanilide (niclosamide)# · aminoacridine (quinacrine) · butyrophenone (desaspidin) · chlorophenol (dichlorophen)
antinematodal agents (macrofilaricides)		binds tubulin	benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ciclobendazole, flubendazole)
		chloride channel	macrolide (ivermectin#)
		NMDA	tetrahydropyrimidine (pyrantel#, pyrantel pamoate, oxantel)
		Other/unknown	piperazine (piperazine · diethylcarbamazine#) · thiazole (levamisole#) · quinolinium (pyrvinium) · benzylammonium (bephenium) · naphthalenesulfonate (suramin#) · tribendimidine

「bephenium compound」

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ベフェニウム化合物

[Martindale-1] Sweetman S (ed.) (2009). Martindale: The complete drug reference (36th ed.). London: Pharmaceutical Press. p. 143. ISBN 978-0-85369-840-1.

[2] Jayewardene G, Ismail MM, Wijayaratnam Y (July 1960). "Bephenium hydroxynaphthoate in treatment of ascariasis". Br Med J 2 (5194): 268–71. doi:10.1136/bmj.2.5194.268. PMC 2097409. PMID 14406934.

[POC-IT-3] Pham PA (March 19, 2009). "Bephenium hydroxynaphthoate". Point-of-Care Information Technology ABX Guide. Johns Hopkins University. Retrieved on March 25, 2011. Freely available with registration.

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bephenium