WordNet

capable of expelling or destroying parasitic worms (同)anthelminthic, helminthic, parasiticidal
an agent that kills worms (especially those in the intestines)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/15 18:10:55」(JST)

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Anthelmintic effect of papain on Heligmosomoides bakeri.

Anthelmintics or antihelminthics are drugs that expel parasitic worms (helminths) from the body, by either stunning or killing them. They may also be called vermifuges (stunning) or vermicides (killing).

Pharmaceuticals

Benzimidazoles:
- Albendazole – effective against threadworms, roundworms, whipworms, tapeworms, hookworms
- Mebendazole – effective against pinworms, roundworms and hookworms
- Thiabendazole – effective against roundworms, hookworms
- Fenbendazole – effective against gastrointestinal parasites
- Triclabendazole – effective against liver flukes
- Flubendazole – effective against most intestinal parasites

Abamectin – effective against most common intestinal worms, except tapeworms, for which praziquantel is commonly used in conjunction with abamectin
Diethylcarbamazine – effective against Wuchereria bancrofti, Brugia malayi, Brugia timori, tropical pulmonary eosinophilia, loiasis
Niclosamide – effective against tapeworms
Ivermectin – effective against most common intestinal worms (except tapeworms)
Suramin – It is used for treatment of human sleeping sickness caused by trypanosomes
Pyrantel pamoate – effective against most nematode infections
Levamisole
Praziquantel – effective against cestodes, some trematodes
Octadepsipeptides (e.g.: Emodepside) – effective against a variety of gastrointestinal helminths
Aminoacetonitrile derivatives (e.g. Monepantel): effective against a variety of gastrointestinal roundworms including those resistant to other anthelmintic classes.
Spiroindoles (e.g. derquantel): effective against a range of gastrointestinal roundworms including those resistant to other anthelmintic classes
Pelletierine sulphate effective against diverse tapeworms, ring worms and nematodes.^[1]

Anthelmintic resistance

The ability of worms to survive treatments that are generally effective at the recommended dose rate is considered a major threat to the future control of worm parasites of small ruminants and horses. This is especially true of nematodes and has contributed to the development of aminoacetonitrile derivatives for treatment against drug resistant nematodes.

The clinical definition of resistance is a 95% or less reduction in a "Fecal Egg Count" test.^{[clarification needed]}

Treatment with an antihelminthic drug kills worms whose phenotype renders them susceptible to the drug. Worms that are resistant survive and pass on their "resistance" genes. Resistant worms accumulate and finally treatment failure occurs. See drug resistance.

References

Footnotes

^ http://www.iasj.net/iasj?func=fulltext&aId=47308

General references

Department of the Army Headquarters (2004). U.S. Army Survival Manual Fm 21–76. Barnes & Noble Inc. ISBN 0-7607-4988-4.

External links

Anthelmintics at the US National Library of Medicine Medical Subject Headings (MeSH)
Plant products in the treatment and control of filariasisand other helminth infections and assay systems for antifilarial/anthelminthic activity.
Holden-Dye, L. and Walker, R.J.Anthelmintic drugs (November 02, 2007), WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.143.1 (English)

This antiinfective drug article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 回虫症 ascariasis
2. 集団寄生虫駆除 population deworming
3. Hookworm-related cutaneous larva migrans
4. 疥癬 scabies

English Journal

A simple extraction method for the simultaneous detection of tetramisole and diethylcarbamazine in milk, eggs, and porcine muscle using gradient liquid chromatography-tandem mass spectrometry.

Zhang D1, Park JA1, Kim DS1, Kim SK1, Shin SJ2, Shim JH3, Shin SC4, Kim JS1, Abd El-Aty AM5, Shin HC6.
Food chemistry.Food Chem.2016 Feb 1;192:299-305. doi: 10.1016/j.foodchem.2015.07.014. Epub 2015 Jul 6.
Analysis of residual quantities of contaminants in foods of animal origin is crucial for quality control of consumer products. This study was aimed to develop a simple and raid analytical method for detection of tetramisole and diethylcarbamazine using gradient liquid chromatography coupled with tan
PMID 26304351

Viability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM).

Rinaldi G1, Loukas A2, Brindley PJ1, Irelan JT3, Smout MJ2.
International journal for parasitology. Drugs and drug resistance.Int J Parasitol Drugs Drug Resist.2015 Aug 6;5(3):141-8. doi: 10.1016/j.ijpddr.2015.07.002. eCollection 2015.
Infection with helminth parasites causes morbidity and mortality in billions of people and livestock worldwide. Where anthelmintic drugs are available, drug resistance is a major problem in livestock parasites, and a looming threat to public health. Monitoring the efficacy of these medicines and scr
PMID 26288742

In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi.

O'Neill M1, Geary JF2, Agnew DW2, Mackenzie CD2, Geary TG1.
International journal for parasitology. Drugs and drug resistance.Int J Parasitol Drugs Drug Resist.2015 Jul 7;5(3):135-40. doi: 10.1016/j.ijpddr.2015.06.002. eCollection 2015.
The use of a microfilaricidal drug for the control of onchocerciasis and lymphatic filariasis necessitates prolonged yearly dosing. Prospects for elimination or eradication of these diseases would be enhanced by availability of a macrofilaricidal drug. Flubendazole (FLBZ), a benzimidazole anthelmint
PMID 26288741

Japanese Journal

Parasitology : Reduced Efficacy of Ivermectin Treatments in Gastrointestinal Nematode Infections of Grazing Cattle in Japan

KUDO Noboru,YOSHIOKA Toshiro,WATANABE Yasushi [他]
The journal of veterinary medical science 76(11), 1487-1491, 2014-11
NAID 40020277593

Where to deliver baits for deworming urban red foxes for Echinococcus multilocularis control: new protocol for micro-habitat modeling of fox denning requirements

Ikeda Takako,Yoshimura Masashi,Onoyama Keiichi,Oku Yuzaburo,Nonaka Nariaki,Katakura Ken
Parasites & Vectors 7, 357, 2014-08-06
… Background: Deworming wild foxes by baiting with the anthelmintic praziquantel is being established as a preventive technique against environmental contamination with Echinococcus multilocularis eggs. …
NAID 120005476206

東北地方で飼養されている黒毛和種およびホルスタイン種育成牛へのアベルメクチン系薬剤投与による駆虫とそれによる生産性への波及効果に関する研究

髙橋史昭
Japanese Journal of Large Animal Clinics 5(2), 65-75, 2014
宮城県では，全国各地から気高系黒毛和種繁殖素牛の導入が推奨された．これは肥育素牛の産肉能力の向上をもたらした反面，乳頭糞線虫（SPL）のような消化管内線虫（GIN）の侵入に伴う病害も増加させた．また野外放牧場のホルスタイン種育成乳牛でもピロプラズマ対策とは対照的にGINへの対策はほとんど実施されておらず，増体や繁殖成績不振の要因と推察された．そこで，アベルメクチン系薬剤投与による駆虫効果および生産 …
NAID 130004715446

Related Pictures

★リンクテーブル★

リンク元	「駆虫薬」「駆虫剤」「antiparasitic」「antiparasitic drug」「antiparasitic agent」

「駆虫薬」

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英: anthelmintic, anthelmintics
ラ: anthelmintica
関

http://en.wikipedia.org/wiki/Anthelmintic

antiplatyhelmintic agents	Antitrematodals (schistosomicides)	binds tubulin	benzimidazole (Triclabendazole#)
		acetylcholinesterase inhibitor	phosphonic acid (metrifonate)
		Other/unknown	quinoline (praziquantel#, oxamniquine#) · phenol (bithionol) · thiazole ([[niridazole]) · arylsulfonate (stibophen)
	anticestodals (taeniacides)	binds tubulin	benzimidazole (albendazole#)
	anticestodals (taeniacides)	Other/unknown	salicylanilide (niclosamide)# · aminoacridine (quinacrine) · butyrophenone (desaspidin) · chlorophenol (dichlorophen)
antinematodal agents (macrofilaricides)		binds tubulin	benzimidazole (mebendazole#, thiabendazole, albendazole#, fenbendazole, ciclobendazole, flubendazole)
		chloride channel	macrolide (ivermectin#)
		NMDA	tetrahydropyrimidine (pyrantel#, pyrantel pamoate, oxantel)
		Other/unknown	piperazine (piperazine · diethylcarbamazine#) · thiazole (levamisole#) · quinolinium (pyrvinium) · benzylammonium (bephenium) · naphthalenesulfonate (suramin#) · tribendimidine