WordNet

PrepTutorEJDIC

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/02/14 15:41:59」(JST)

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

Lüthje S, Möller B, Perrineau FC, Wöltje K.Source1 Biocenter Klein Flottbek, University of Hamburg , Hamburg, Germany .
Antioxidants & redox signaling.Antioxid Redox Signal.2013 Feb 28. [Epub ahead of print]
Abstract Significance: Several redox compounds, including respiratory burst oxidase homologs (Rboh) and iron chelate reductases have been identified in animal and plant plasma membrane (PM). Studies using molecular biological, biochemical, and proteomic approaches suggest that PM redox systems of pl
PMID 23265437

The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock.

Lugrin J, Ciarlo E, Santos A, Grandmaison G, Dos Santos I, Le Roy D, Roger T.SourceInfectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, rue du Bugnon 46, Lausanne, Switzerland.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jun;1833(6):1498-510. doi: 10.1016/j.bbamcr.2013.03.004. Epub 2013 Mar 13.
Sirtuins (SIRT1-7) are NAD(+)-dependent histone deacetylases (HDACs) that play an important role in the control of metabolism and proliferation and the development of age-associated diseases like oncologic, cardiovascular and neurodegenerative diseases. Cambinol was originally described as a compoun
PMID 23499872

Insulin increases glomerular filtration barrier permeability through dimerization of protein kinase G type Iα subunits.

Piwkowska A, Rogacka D, Kasztan M, Angielski S, Jankowski M.SourceMossakowski Medical Research Centre Polish Academy of Sciences, Laboratory of Molecular and Cellular Nephrology, Gdańsk, Poland. Electronic address: apiwkowska@cmdik.pan.pl.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jun;1832(6):791-804. doi: 10.1016/j.bbadis.2013.02.011. Epub 2013 Feb 21.
The increase in the permeability of the glomerular barrier filtration to albumin is a well-known feature of diabetic microvasculature and a negative prognostic factor for vascular complications. However, the underlying mechanisms are incompletely understood. We demonstrated recently that superoxide
PMID 23454089

Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice

Takada Shingo,Hirabayashi Kagami,Kinugawa Shintaro,Yokota Takashi,Matsushima Shouji,Suga Tadashi,Kadoguchi Tomoyasu,Fukushima Arata,Homma Tsuneaki,Mizushima Wataru,Masaki Yoshihiro,Furihata Takaaki,Katsuyama Ryoichi,Okita Koichi,Tsutsui Hiroyuki
European Journal of Pharmacology 740, 690-696, 2014-10-05
… NAD(P)H oxidase activity was significantly increased in the HFD+vehicle compared with the ND+vehicle, and this increase was ameliorated in HFD+pioglitazone mice. …
NAID 120005476207

The Small GTPases Regulate HMC05-Induced NQO-1 Expression with an Antioxidant Effect in Smooth Muscle Cells

リンク元	「ペラグラ」「ニコチンアミドアデニンジヌクレオチド」「ニコチン酸アミド」「ニコチン酸」「ヘモフィルス属」
拡張検索	「NADH」「reduced NAD」「還元型NAD」「NADグリコヒドロラーゼ」「NADH-NADPH oxidoreductase」
関連記事	「NA」「N」

カルチノイド症候群：トリプトファンを原料に大量の5-hydroxytryptamine 5-HT セロトニンを産生(体内のトリプトファン代謝の60%を占めてしまうほど)するためトリプトファンが欠乏し、ナイアシン欠乏を来す(HBC.498)

初期症状：食欲減退、全身倦怠感、易刺激性(irritability)、腹痛、嘔吐
日光照射部位の皮疹(pigmented and scaling)(Casal's necklace, 進行例で見られる)　→　bright red glossitis
食道炎、腟炎
下痢(直腸炎 proctitisや消化不良に起因する)、うつ、てんかん発作、認知症