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- infectious venereal ulcer
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/04 05:00:09」(JST)
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- 1. 軟性下疳 chancroid
- 2. 性器潰瘍患者へのアプローチ approach to the patient with genital ulcers
- 3. 小児における鼠径部腫脹の評価 evaluation of inguinal swelling in children
- 4. HIV感染患者における性器単純ヘルペスウイルスの疫学、臨床症状、および診断 epidemiology clinical manifestations and diagnosis of genital herpes simplex virus in hiv infected patients
- 5. Acute and early HIV infection: Clinical manifestations and diagnosis
English Journal
- Periodic presumptive treatment of curable sexually transmitted infections among sex workers: recent experience with implementation.
- Steen R, Chersich M, de Vlas SJ.SourceaDepartment of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands bCentre for Health Policy, Faculty of Health Sciences, School of Public Health, University of Witwatersrand, South Africa cInternational Centre for Reproductive Health, Department of Obstetrics and Gynaecology, Ghent University, Belgium.
- Current opinion in infectious diseases.Curr Opin Infect Dis.2012 Feb;25(1):100-6.
- PURPOSE OF REVIEW: Curable sexually transmitted infections (STIs) are common occupational hazards for female sex workers in low-income and middle-income countries. Yet, most infections are asymptomatic and sensitive screening tests are rarely affordable or feasible. Periodic presumptive treatment (P
- PMID 22156895
- Oral immunization using HgbA in a recombinant chancroid vaccine delivered by attenuated Salmonella typhimurium SL3261 in the temperature-dependent rabbit model.
- Breau C, Cameron DW, Desjardins M, Lee BC.SourceDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, Canada K1H 8M5.
- Journal of immunological methods.J Immunol Methods.2012 Jan 31;375(1-2):232-42. Epub 2011 Nov 10.
- Chancroid, a sexually transmitted genital ulcer disease caused by the Gram-negative bacterium Haemophilus ducreyi, facilitates the acquisition and transmission of HIV. An effective vaccine against chancroid has not been developed. In this preliminary study, the gene encoding the H. ducreyi outer mem
- PMID 22100216
- On the possible roles of N-terminal His-rich domains of Cu,Zn SODs of some Gram-negative bacteria.
- Arus D, Jancsó A, Szunyogh D, Matyuska F, Nagy NV, Hoffmann E, Körtvélyesi T, Gajda T.SourceDepartment of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary.
- Journal of inorganic biochemistry.J Inorg Biochem.2012 Jan;106(1):10-8. Epub 2011 Sep 29.
- The Cu,Zn superoxide dismutases (Cu,Zn SOD) isolated from some Gram-negative bacteria possess a His-rich N-terminal metal binding extension. The N-terminal domain of Haemophilus ducreyi Cu,Zn SOD has been previously proposed to play a copper(II)-, and may be a zinc(II)-chaperoning role under metal i
- PMID 22105012
Japanese Journal
- A CdtA-CdtC complex can block killing of HeLa cells by Haemophilus ducreyi cytolethal distending toxin
- DENG K.
- Infect. Immun. 71, 6633-6640, 2003
- NAID 30020831502
- The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA
- FRISAN T.
- Cell. Microbiol. 5, 695-707, 2003
- NAID 30014675890
- The cytolethal distending toxin of Haemophilus ducreyi inhibits endothelial cell proliferation
- SVENSSON L. A.
- Infect. Immun. 70, 2665-2669, 2002
- NAID 30020830097
Related Links
- Coccobacillus ducreyi, Bacillus ulceris cancrosi, Haemophilus ducreyi Description and significance Haemophilus ducreyi causes the sexually transmitted disease, Chancroid. There has been renewed interest in this bacillus because ...
- Chancroid is a sexually transmitted infection caused by Haemophilus ducreyi. This fastidious, Gram-negative coccobacilli dies rapidly outside the human host, making diagnostic testing using culture methods difficult.
Related Pictures
★リンクテーブル★
| リンク元 | 「エリスロマイシン」「ヘモフィルス属」「下疳」「H. ducreyi」 |
「エリスロマイシン」
- 英
- erythromycin, EM
- 商
- アイロタイシン、エリスロシン、エコリシン、エリコリ、E-Mycin, Ery-Tab, Ery-C, Ilosone, Eryc, Ilotycin
- 関
- 抗菌薬
- first aid step1 2006 p.141,143,144,144-145,165,166,169,170,173,178,208
分類
-
- 14員環マクロライド
特徴
- ペニシリン過敏症の患者に対する第一選択となる
- P450の阻害作用を持つので他の薬剤との相互作用に注意が必要。
- 耐性菌が多い。MRSAは100%、肺炎球菌は50%が耐性を持つ (SMB.157)
構造
作用機序
- 50Sに結合し、リボソームの動きを妨げることで、A siteのpeptidyl-tRNAをP siteに移動するのを妨げる？
- inhibit protein synthesis by blocking translocation
抗菌スペクトル
- IRE.166
- グラム陽性球菌、細胞内寄生菌(マイコプラズマ・ニューモニエ、クラミジア・トラコマティス、クラミドフィラ・ニューモニエ)、スピロヘータ(Borrelia burddorferi)、グラム陰性菌(Bordetella pertussis、Bartonella henselae、Bartonella quintana、Haemophilus ducreyi)
動態
- IRE.166
- 分布：組織移行性がよく、ほとんどの組織に移行する。中耳、前立腺にも移行する。中枢神経系、関節腔には移行しづらい。
- 排泄：肝排泄。胆汁中に排泄。血液透析、腹膜透析では除去されない。
適応
注意
禁忌
副作用
USMLE
- Q book p.356 6
「ヘモフィルス属」
- ラ
- Haemophilus
- 英
- hemophilus
- 同
- Haemophilus属、ヘモフィラス
- 関
- 細菌
生物的特徴
- パスツレラ科
- グラム陰性桿菌
- 発育因子として、X因子(プロトポルフィリンIX or プロトヘム) and/or V因子(NAD or NADP)が必要
- 莢膜非保有菌(ウイルス感染に続発する肺炎)と莢膜保有菌(血清型b型が多い。化膿性髄膜炎、敗血症、閉塞性喉頭炎を起こす)がある。
ヘモフィルス感染症
「下疳」
- 潰瘍に含まれる概念。性病の潰瘍を指す。
- 梅毒スピロヘーター：硬性下疳：梅毒で見られる初期の硬結
- 軟性下疳菌 ：軟性下疳：Haemophilus ducreyiによる性感染症。感染後数日で局部に丘疹を生じ、やがて潰瘍を形成、その後鼠径部の有痛性リンパ節腫脹がみられる。