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Host Cell Cytotoxicity and Cytoskeleton Disruption by CerADPr, an ADP-Ribosyltransferase of Bacillus cereus G9241.

Simon NC, Vergis JM, Ebrahimi AV, Ventura CL, O'Brien AD, Barbieri JT.SourceMicrobiology, Immunology, and Molecular Genetics, Medical College of Wisconsin , Milwaukee, Wisconsin 53226, United States.
Biochemistry.Biochemistry.2013 Apr 2;52(13):2309-18. doi: 10.1021/bi300692g. Epub 2013 Mar 20.
Bacillus cereus G9241 was isolated from a welder suffering from an anthrax-like inhalation illness. B. cereus G9241 encodes two megaplasmids, pBCXO1 and pBC210, which are analogous to the toxin- and capsule-encoding virulence plasmids of Bacillus anthracis. Protein modeling predicted that the pBC210
PMID 22934824

Jankevicius G, Hassler M, Golia B, Rybin V, Zacharias M, Timinszky G, Ladurner AG.Source1] Butenandt Institute of Physiological Chemistry, Ludwig Maximilians University of Munich, Munich, Germany. [2] International Max Planck Research School for Molecular and Cellular Life Sciences, Martinsried, Germany. [3].
Nature structural & molecular biology.Nat Struct Mol Biol.2013 Apr;20(4):508-14. doi: 10.1038/nsmb.2523. Epub 2013 Mar 10.
ADP-ribosylation is a reversible post-translational modification with wide-ranging biological functions in all kingdoms of life. A variety of enzymes use NAD(+) to transfer either single or multiple ADP-ribose (ADPr) moieties onto distinct amino acid substrates, often in response to DNA damage or ot
PMID 23474712

Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease.

Tatsuno I, Okada R, Zhang Y, Isaka M, Hasegawa T.AbstractBACKGROUND: CovRS (or CsrRS) is a two-component regulatory system that regulates the production of multiple virulence factors in Streptococcus pyogenes. covS mutations are often found in isolates recovered from mice that have been experimentally infected with S. pyogenes and covS mutations enhance bacterial virulence in an invasive infection mouse model. In addition, covS mutations were detected more frequently in a panel of clinical isolates from severe invasive streptococcal infections than those from non-severe infections. Thus, covS mutations may be associated with the onset of severe invasive infections.
BMC research notes.BMC Res Notes.2013 Mar 28;6(1):126. [Epub ahead of print]
BACKGROUND: CovRS (or CsrRS) is a two-component regulatory system that regulates the production of multiple virulence factors in Streptococcus pyogenes. covS mutations are often found in isolates recovered from mice that have been experimentally infected with S. pyogenes and covS mutations enhance b
PMID 23537349