関: dehydroepiandrosterone sulfate

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the 19th letter of the Roman alphabet (同)s

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sulfurの化学記号 / {略}South[ern]

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/20 17:14:22」(JST)

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Dehydroepiandrosterone sulfate or DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA).

Synthesis

Dehydroepiandrosterone sulfate is produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.

In the zona reticularis layer of the adrenal cortex, DHEA-sulfate is generated by SULT2A1.^[1] This layer of the adrenal cortex is thought to be the primary source of serum DHEA-sulfate. DHEA sulfate levels decline as a person ages as the reticularis layer diminishes in size.

Use as biomarker

Dehydroepiandrosterone sulfate levels above 1890 micromol/L or 700-800 µg/dL are highly suggestive of adrenal dysfunction because DHEA-S is made exclusively by the adrenal glands.^[2]^[3]

Reference ranges

Reference ranges for dehydroepiandrosterone sulfate in females^[4]
Tanner stage and average age		Lower limit	Upper limit	Unit
Tanner stage I	>14 days	16	96	µg/dL
Tanner stage II	10.5 years	22	184
Tanner stage III	11.6 years	<15	296
Tanner stage IV	12.3 years	17	343
Tanner stage V	14.5 years	44	332
18-29 years		44	332
30-39 years		31	228
40-49 years		18	244
50-59 years		<15	200
> or =60 years		<15	157

Reference ranges for dehydroepiandrosterone sulfate in males^[4]
Tanner stage and average age		Lower limit	Upper limit	Unit
Tanner stage I	>14 days	<15	120	µg/dL
Tanner stage II	11.5 years	<15	333
Tanner stage III	13.6 years	<15	312
Tanner stage IV	15.1 years	29	412
Tanner stage V	18.0 years	89	457
18-29 years		89	457
30-39 years		65	334
40-49 years		48	244
50-59 years		35	179
> or =60 years		25	131

References

^ Rainey WE, Nakamura Y (February 2008). "Regulation of the adrenal androgen biosynthesis". J. Steroid Biochem. Mol. Biol. 108 (3-5): 281–6. doi:10.1016/j.jsbmb.2007.09.015. PMC 2699571. PMID 17945481.
^ Somani N, Harrison S, Bergfeld WF (2008). "The clinical evaluation of hirsutism". Dermatologic therapy 21 (5): 376–91. doi:10.1111/j.1529-8019.2008.00219.x. PMID 18844715.
^ "Polycystic Ovarian Syndrome Workup". eMedicine. 25 October 2011. Retrieved 19 November 2011.
^ ^a ^b Dehydroepiandrosterone Sulfate (DHEA-S), Serum at Mayo Foundation For Medical Education And Research. Retrieved July 2012

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UpToDate Contents

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1. 男性型多毛症を有する閉経期女性の評価 evaluation of premenopausal women with hirsutism
2. デヒドロエピアンドロステロンおよびその硫酸塩 dehydroepiandrosterone and its sulfate
3. 副腎アンドロゲンの測定 measurement of adrenal androgens
4. 成人における多嚢胞性卵巣症候群の診断 diagnosis of polycystic ovary syndrome in adults
5. 早期副腎皮質性第二次性徴 premature adrenarche

English Journal

Low serum sex hormone-binding globulin: Marker of inflammation?

Liao CH, Li HY, Yu HJ, Chiang HS, Lin MS, Hua CH, Ma WY.SourceDivision of Urology, Department of Surgery, College of Medicine, Ph.D. Program in Nutrition and Food Sciences, and Graduate Institute of Basic Medicine, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan.
Clinica chimica acta; international journal of clinical chemistry.Clin Chim Acta.2012 Apr 11;413(7-8):803-7. Epub 2012 Jan 24.
BACKGROUND: Low sex hormone-binding globulin (SHBG) is associated with metabolic syndrome (MetS), but its relationship with inflammation is unclear.METHODS: This cross-sectional study included 696 subjects (255 men, 235 pre-menopausal women, and 206 postmenopausal women). Body mass index, waist circ
PMID 22293276

Plasma dehydroepiandrosterone sulphate and insulin-like growth factor I levels in obstructive sleep apnoea syndrome.

Makino S, Fujiwara M, Handa H, Fujie T, Aoki Y, Hashimoto K, Terada Y, Sugimoto T.SourceDepartments of Internal Medicine Respiratory Therapy, Osaka Gyomeikan Hospital, Kasugade-naka, Konohana-ku, Osaka Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Okoh-cho, Nankoku, Kochi, Japan.
Clinical endocrinology.Clin Endocrinol (Oxf).2012 Apr;76(4):593-601. doi: 10.1111/j.1365-2265.2011.04237.x.
Context We aimed to assess whether obstructive sleep apnoea syndrome (OSAS) affects plasma IGF-1 and dehydroepiandrosterone sulphate (DHEA-S) levels in men, factors implicated in the development of age-related metabolic disorders. Design We conducted a cross-sectional and longitudinal clinical
PMID 21951159

Japanese Journal

NASH発症における抗加齢ホルモンDHEA-Sの役割 (特集 NASH/NAFLD発症のメカニズム)

角田圭雄,米井嘉一,内藤裕二 [他]
消化器内科 52(5), 519-525, 2011-05
NAID 40018891066

加齢と副腎皮質ホルモン (特集加齢に伴う内分泌代謝疾患)

柴田洋孝
最新医学 66(4), 851-855, 2011-04
NAID 40018803776

Related Pictures

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★リンクテーブル★

リンク元	「副腎皮質ホルモン」「エストリオール」「17-ケトステロイド」
関連記事	「DHEA」「S」「DH」「DHE」

「副腎皮質ホルモン」

Dehydroepiandrosterone sulfate
	IUPAC name [(3S,8R,9S,10R,13S,14S)-10,13-Dimethyl-17-oxo-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-yl] hydrogen sulfate
	Other names Prasterone sulfate
Identifiers
Abbreviations	DHEAS
CAS number	651-48-9
PubChem	12594
Jmol-3D images	Image 1
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O) CC=C4[C@@]3(CC[C@@H](C4)OS(=O)(=O)O)C ;
Properties
Molecular formula	C19H28O5S
Molar mass	368.49 g/mol
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	(verify) (what is: /?)
	Infobox references

　　[★]

英: adrenocortical hormone
同: 副腎皮質ステロイド adrenocorticoids
関: 副腎皮質刺激ホルモン放出ホルモン、副腎皮質刺激ホルモン; ステロイド
関: 副腎、副腎皮質、ステロイド、コルチコステロイド、ステロイドホルモン、コルチコイド。副腎皮質ホルモン剤

図：SP.891(組織),892(構造式)
副腎皮質の球状層、索状層、網状層で合成される

種類(主要なもののみ)

電解質コルチコイド

球状層から分泌される。アルドステロン

糖質コルチコイド

索状層から分泌される。コルチゾール

副腎アンドロジェン

網状層から分泌される。アンドロステンジオン

コレステロール cholesterol
↓CYP11A1
プレグネノロン pregnenolone	－－→ CYP17 17α-hydroxylase	17α-ヒドロキシプレグネノロン 17α-hydroxypregnenolone	－－→ CYP17 17α-hydroxylase	デヒドロエピアンドロステロン dehydroepiandrosterone DHEA
↓3β-HSD 3β-hydroxysteroid dehydrogenase		↓3β-HSD		↓3β-HSD
プロゲステロン progesterone	－－→ CYP17 17α-hydroxylase	17α-ヒドロキシプロゲステロン 17α-hydroxyprogesterone	－－→ CYP17 17α-hydroxylase	アンドロステンジオン androstenedione Δ⁴androstene-3,17-dion
↓CYP21 21-hydroxylase		↓CYP21 21-hydroxylase
デオキシコルチコステロン deoxycorticosterone		11-デオキシコルチゾール 11-deoxycortisol
↓CYP11B2　11β-hydroxylase		↓CYP11B1　11β-hydroxylase
コルチコステロン corticosterone		コルチゾール cortisol
↓CYP11B2 18-hydroxylase
18-ヒドロキシコルチコステロン 18-hydroxycorticosterone
↓CYP11B2 18-hydroxydehydrogenase
アルドステロン aldosterone

球状増 zona glomerulosa		索状層 zona fasciculata		網状層 zona reticularis

臨床関連

21-hydroxylaseが正常に機能しないことにより生じる (L.320)

薬理学

副腎皮質ホルモン製剤

副腎皮質から分泌されるホルモン (SP.895)

名称		血漿濃度 (ng/ml)	1日分泌量 (mg/day)
糖質コルチコイド	コルチゾール	40～180	15～20
糖質コルチコイド	コルチコステロン	2～6	2～5
鉱質コルチコイド	アルドステロン	0.05～0.20	0.05～0.15
鉱質コルチコイド	11-DOC	0.05～0.30	0.10～0.20
副腎アンドロジェン	DHEA	2～8	7～15
	DHEA-S	1～4
	アンドロステンジオン	1～2	2～3