WordNet
- dividing an area into zones or sections reserved for different purposes such as residence and business and manufacturing etc
PrepTutorEJDIC
- (都市計画の)区画制,地区制
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/31 22:13:00」(JST)
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- 1. 副腎ステロイド生合成 adrenal steroid biosynthesis
- 2. 副腎の外科解剖学 surgical anatomy of the adrenal glands
- 3. 家族性アルドステロン症 familial hyperaldosteronism
- 4. 副腎皮質機能の臨床検査の基本原則 basic principles in the laboratory evaluation of adrenocortical function
- 5. 11βヒドロキシラーゼ欠損症による先天性副腎過形成 congenital adrenal hyperplasia due to 11 beta hydroxylase deficiency
English Journal
- Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: The metabotropic pathway.
- Felizola SJ, Nakamura Y, Satoh F, Morimoto R, Kikuchi K, Nakamura T, Hozawa A, Wang L, Onodera Y, Ise K, McNamara KM, Midorikawa S, Suzuki S, Sasano H.Author information Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.AbstractBACKGROUND: l-glutamate is a major excitatory neurotransmitter in the mammalian brain. Glutamate receptors have been reported in the rat adrenal cortex and in human aldosterone-producing adenomas (APA). However, details regarding the expression levels and functions of these receptors in human adrenocortical tissues remain unknown.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Jan 25;382(1):170-7. doi: 10.1016/j.mce.2013.09.025. Epub 2013 Sep 27.
- BACKGROUND: l-glutamate is a major excitatory neurotransmitter in the mammalian brain. Glutamate receptors have been reported in the rat adrenal cortex and in human aldosterone-producing adenomas (APA). However, details regarding the expression levels and functions of these receptors in human adreno
- PMID 24080311
- Immunolocalization of murine type VI 3β-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta.
- Yamamura K, Doi M, Hayashi H, Ota T, Murai I, Hotta Y, Komatsu R, Okamura H.Author information Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.AbstractThe enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is essential for the biosynthesis of all active steroid hormones, such as those secreted from the adrenal gland, testis, ovary, skin and placenta. The 3β-HSD enzymes exist in multiple isoforms in humans and rodents. To date, six different isoforms have been identified in the mouse, and these isoforms are speculated to play different roles in different tissues. We previously showed that the murine type VI 3β-HSD isoform (Hsd3b6) is expressed specifically in the aldosterone-producing zona glomerulosa cells within the adrenal gland and that its overexpression causes abnormally increased aldosterone synthesis, revealing a crucial (or rate-limiting) role of this enzyme in steroidogenesis. However, potential contributions of this enzyme to the steroid hormone synthesis outside the adrenal glands are poorly understood. This paucity of knowledge is partly because of the lack of isoform-specific antibody that can be used for immunohistochemistry. Here, we report the development and characterization of specific antibody to Hsd3b6 and show the results of immunohistochemistry for the adrenal gland, testis, ovary, skin and placenta. As expected, Hsd3b6 immunoreactivities within the adrenal gland were essentially confined to the zona glomerulosa cells, where aldosterone is produced. By contrast, no immunopositive cells were observed in the zona fasciculata, which is where corticosterone is produced. In the gonads, while the ovaries did not show any detectable immunoreactivity to Hsd3b6, the testes displayed intense immunoreactivities within the interstitial Leydig cells, where testosterone is produced. In the skin, positive immunoreactivities to Hsd3b6 were only seen in the sebaceous glands, suggesting a specific role of this enzyme in sebaceous function. Moreover, in the placenta, Hsd3b6 was specifically found in the giant trophoblast cells surrounding the embryonic cavity, which suggests a role for this enzyme in local progesterone production that is required for proper embryonic implantation and/or maintenance of pregnancy. Taken together, our data revealed that Hsd3b6 is localized in multiple specific tissues and cell types, perhaps thereby involved in biosynthesis of a number of tissue-specific steroid hormones with different physiological roles.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2014 Jan 25;382(1):131-8. doi: 10.1016/j.mce.2013.09.014. Epub 2013 Sep 25.
- The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is essential for the biosynthesis of all active steroid hormones, such as those secreted from the adrenal gland, testis, ovary, skin and placenta. The 3β-HSD enzymes exist in multiple isoforms in humans and rodents. To date, six differ
- PMID 24075909
- A new stress model, a scream sound, alters learning and monoamine levels in rat brain.
- Hu L, Yang J, Song T, Hou N, Liu Y, Zhao X, Zhang D, Wang L, Wang T, Huang C.Author information Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China.AbstractMost existing animal models for stress involve the simultaneous application of physical and psychological stress factors. In the current study, we described and used a novel psychological stress model (scream sound stress). To study the validity of it, we carried out acute and chronic scream sound stress. First, adult Sprague-Dawley (SD) rats were randomly divided into white noise, stress and background groups. The white noise group and stress group were treated with white noise and scream sound for 4h in the morning respectively. Compared with white noise and background groups, exposure to acute scream sound increased corticosterone (CORT) level and decreased latency in Morris water maze (MWM) test. The levels of noradrenaline (NE), dopamine (DA), 5-hydroxytryptamine (5-HT), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were altered in the striatum, hypothalamus and hippocampus of stress rats. Second, adult SD rats were randomly divided into background and stress groups, which were treated with scream sound for three weeks. Exposure to chronic scream sound suppressed body weight gain, increased corticosterone (CORT) level, influenced the morphology of adrenal gland, improved spleen and thymus indices, and decreased latency in MWM test. NE, DA, DOPAC, HVA and 5-HIAA levels were also altered in the brain of stress rats. Our results suggested that scream sound, as a novel stressor, facilitated learning ability, as well as altered monoamine levels in the rat brain. Moreover, scream sound is easy to apply and can be applied in more animals at the same time.
- Physiology & behavior.Physiol Behav.2014 Jan 17;123:105-13. doi: 10.1016/j.physbeh.2013.09.010. Epub 2013 Oct 2.
- Most existing animal models for stress involve the simultaneous application of physical and psychological stress factors. In the current study, we described and used a novel psychological stress model (scream sound stress). To study the validity of it, we carried out acute and chronic scream sound s
- PMID 24096192
Japanese Journal
- A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
- Ota Yoshio,Imai Toshio,Onose Jun-ichi [他],Takami Shigeaki,Cho Young-Man,Hirose Masao,Nishikawa Akiyoshi
- Journal of toxicological sciences 34(3), 305-313, 2009-06-01
- … At 2.0%, hypertrophy of cortical cells in zona fasciculata was also increased in the adrenals. …
- NAID 110007226352
- A Morphometric Study of the Adrenal Cortex of the Female DDD Mouse(Anatomy)
- Tsujio Masashi,Mizorogi Toshihiro,Nishijima Kazutoshi [他],KUWAHARA Sachi,AOYAMA Hiroaki,OHNO Tamio,TANAKA Shin
- The journal of veterinary medical science 71(2), 183-187, 2009-02-25
- … The zona reticularis and zona glomerulosa of parous mice tended to be thicker than those of virgin mice at all ages. … The zona fasciculata lactating parous mice was significantly thicker than that of virgin mice at 20 weeks of age (P<0.01). …
- NAID 110007109595
- Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas.
- Shigematsu Kazuto,Nakagaki Takehiro,Yamaguchi Naohiro,Kawai Kioko,Sakai Hideki,Takahara Osamu
- European journal of endocrinology 158(6), 867-878, 2008-06-00
- … Most of the cortical nodules in zona fasciculata to zona reticularis showed a suppressed steroidogenesis in the cortices attached to adenoma, but some expressed intensely all necessary steroidogenic enzyme mRNAs for cortisol synthesis. …
- NAID 120001422841
Related Links
- zona /zo·na/ (zo´nah) pl. zo´nae [L.] 1. zone. 2. herpes zoster. zona arcua´ta inner tunnel. zona cilia´ris ciliary zone. zona denticula´ta the inner zone of the lamina basilaris of the cochlear duct with the limbus of the osseous spiral ...
- The adrenal Gland is comprised of the capsule, cortex and medulla areas. The Adrenal Cortex: Terms to know and recognize:Zona Glomerulosa- produces hormone Aldosterone Zona fasciculata - produces hormone CortisolZona ...
- zona fasciculata n. The middle portion of the adrenal cortex, where glucocorticoids and other hormones are produced. [From Latin zona a girdle or belt + fasciculus a ... Well known adrenal Intrigue …. Through exterior to inside, these ...
Related Pictures
★リンクテーブル★
| リンク元 | 「副腎皮質ホルモン」「副腎」「副腎皮質」「束状層」「索状帯」 |
| 関連記事 | 「zona」「fasciculata」 |
「副腎皮質ホルモン」
- 英
- adrenocortical hormone
- 同
- 副腎皮質ステロイド adrenocorticoids
- 関
- 副腎皮質刺激ホルモン放出ホルモン、副腎皮質刺激ホルモン
- ステロイド
- 関
- 副腎、副腎皮質、ステロイド、コルチコステロイド、ステロイドホルモン、コルチコイド。副腎皮質ホルモン剤
種類(主要なもののみ)
- 網状層から分泌される。アンドロステンジオン
臨床関連
- 21-hydroxylaseが正常に機能しないことにより生じる (L.320)
薬理学
副腎皮質から分泌されるホルモン (SP.895)
| 名称 | 血漿濃度 (ng/ml) |
1日分泌量 (mg/day) | |
| 糖質コルチコイド | コルチゾール | 40～180 | 15～20 |
| コルチコステロン | 2～6 | 2～5 | |
| 鉱質コルチコイド | アルドステロン | 0.05～0.20 | 0.05～0.15 |
| 11-DOC | 0.05～0.30 | 0.10～0.20 | |
| 副腎アンドロジェン | DHEA | 2～8 | 7～15 |
| DHEA-S | 1～4 | ||
| アンドロステンジオン | 1～2 | 2～3 | |
「副腎」
- 英
- adrenal gland (KH), suprarenal gland (Z)
- 同
- 腎上体
解剖
- 第一腰椎の高さ
血管(図：N.322)
動脈
静脈
- ref(renal_gland_av.png,副腎)
組織
- 皮質
- 髄質
機能
「副腎皮質」
- 英
- adrenal cortex (Z)
- 関
- 副腎
- ATCHは副腎皮質の索状層、網状層に作用して、それぞれの層で糖質コルチコイドと副腎アンドロジェンの産生を促す(2007年後期生理学授業プリント)
構造
ホルモン
まとめ
| 球状層 | zona glomerulosa | アルドステロン |
| 索状層 | zona fasciculata | 糖質コルチコイド |
| 網状層 | zona reticularis | 副腎アンドロジェン |
「束状層」
「索状帯」
- ラ
- zona fasciculata
- 関
- 束状帯、束状層、副腎束状層
「zona」
- n.
「fasciculata」
- ex.