関: dihydroergotamine mesylate

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the 4th letter of the Roman alphabet (同)d

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deuteriumの化学記号

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/29 18:41:23」(JST)

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1. 成人における片頭痛の急性期治療 acute treatment of migraine in adults
2. 小児における片頭痛のマネージメント management of migraine headache in children
3. 薬物乱用頭痛：治療および予後 medication overuse headache treatment and prognosis
4. 片麻痺性片頭痛 hemiplegic migraine
5. 分娩第3期のマネージメントのための子宮収縮薬 uterotonic drugs for management of the third stage of labor

English Journal

Sensory and instrumental analysis of medium and long shelf-life Charentais cantaloupe melons (Cucumis melo L.) harvested at different maturities.

Lignou S, Parker JK, Baxter C, Mottram DS.Author information University of Reading, Department of Food and Nutritional Sciences, Whiteknights, Reading RG6 6AP, UK.AbstractThe flavour profiles of two genotypes of Charentais cantaloupe melons (medium shelf-life and long shelf-life), harvested at two distinct maturities (immature and mature fruit), were investigated. Dynamic headspace extraction (DHE), solid-phase extraction (SPE), gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry/mass spectrometry (GC-O/MS) were used to determine volatile and semi-volatile compounds. Qualitative descriptive analysis (QDA) was used to assess the organoleptic impact of the different melons and the sensory data were correlated with the chemical analysis. There were significant, consistent and substantial differences between the mature and immature fruit for the medium shelf-life genotype, the less mature giving a green, cucumber character and lacking the sweet, fruity character of the mature fruit. However, maturity at harvest had a much smaller impact on the long shelf-life melons and fewer differences were detected. These long shelf-life melons tasted sweet, but lacked fruity flavours, instead exhibiting a musty, earthy character.
Food chemistry.Food Chem.2014 Apr 1;148:218-29. doi: 10.1016/j.foodchem.2013.10.045. Epub 2013 Oct 17.
The flavour profiles of two genotypes of Charentais cantaloupe melons (medium shelf-life and long shelf-life), harvested at two distinct maturities (immature and mature fruit), were investigated. Dynamic headspace extraction (DHE), solid-phase extraction (SPE), gas chromatography-mass spectrometry (
PMID 24262549

Drugs targeting 5-hydroxytryptamine receptors in acute treatments of migraine attacks. A review of new drugs and new administration forms of established drugs.

Tfelt-Hansen PC, Pihl T, Hougaard A, Mitsikostas DD.Author information University of Copenhagen, Glostrup Hospital, Danish Headache Center, Department of Neurology , N39, DK-2600, Glostrup , Denmark ptha@regionh.dk.AbstractIntroduction: The development of sumatriptan, more than 20 years ago, added substantially to the characterization of 5-hydroxytryptamine (5-HT) receptors and their relevance to acute migraine therapy. Recently, 5-HT1F receptor agonists, with no vascular effects, have shown efficacy in the treatment of migraines. Areas covered: This evaluation reviews the recent advances in acute migraine therapy targeting the 5-HT receptor. Specifically, the authors review the pharmacokinetics, pharmacodynamics, clinical efficacy and safety of 5-HT1F receptor agonists and new formulations of sumatriptan and dihydroergotamine (DHE). Expert opinion: Lasmiditan, a non-vascular acting 5-HT1F receptor agonist, is effective in migraine but causes central nervous system-related adverse events, which may considerably limit its clinical use. The efficacy of transdermal sumatriptan is too low for general use in migraine. Intranasal sumatriptan powder could be a step forward compared with oral sumatriptan, but comparative trials are needed. Orally inhaled DHE has a very quick systemic absorption but the onset of effect in migraine is relatively slow with a maximum effect after 2 h. In contrast, orally inhaled DHE results in a low incidence of recurrence. None of these reviewed treatments are likely to fulfill patients' expectations, and the advancement of acute migraine drugs should likely depend on different mechanisms from current 5-HT-related drugs.
Expert opinion on investigational drugs.Expert Opin Investig Drugs.2014 Mar;23(3):375-85. doi: 10.1517/13543784.2014.861817. Epub 2013 Dec 2.
Introduction: The development of sumatriptan, more than 20 years ago, added substantially to the characterization of 5-hydroxytryptamine (5-HT) receptors and their relevance to acute migraine therapy. Recently, 5-HT1F receptor agonists, with no vascular effects, have shown efficacy in the treatment
PMID 24289494

Dihydroartemisinin induces autophagy by suppressing NF-κB activation.

Hu W1, Chen SS1, Zhang JL1, Lou XE1, Zhou HJ2.Author information 1Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.2Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China. Electronic address: zhouhj_zhouhj@yahoo.com.AbstractNuclear factor-kappa B (NF-κB) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DHA) stimulates the induction of autophagy in several cancer cell lines through repression of NF-κB activity. We also show that inhibiting NF-κB results in an accumulation of reactive oxygen species (ROS), which participate in the stimulation of autophagy. These findings present a pathway by which DHA promotes autophagy in cancer cells and provide evidence for the DHA-induced sensitization effect of some chemotherapeutics.
Cancer letters.Cancer Lett.2014 Feb 28;343(2):239-48. doi: 10.1016/j.canlet.2013.09.035. Epub 2013 Oct 4.
Nuclear factor-kappa B (NF-κB) and autophagy are two major regulators involved in both tumor initiation and progression. However, the association between these two signaling pathways still remains obscure. In this work, we demonstrate that dihydroartemisinin (DHA) stimulates the induction of autoph
PMID 24099910

Japanese Journal

画像の平均階調値保存を考慮した強調度が可変なヒストグラム平坦化

川上昂,村平宏太,田口亮
電気学会論文誌. C, 電子・情報・システム部門誌 = The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and System Society 130(9), 1687-1688, 2010-09-01
… In order to preserve the mean brightness, the dynamic histogram equalization (DHE) is proposed. … In this letter, we propose a novel DHE which is called the DHE with variable enhancement degree (DHEwVED). … This method can change from DHE to HE by turning one parameter. …
NAID 10026580071

Edaravone (MCI-186) Scavenges Reactive Oxygen Species and Ameliorates Tissue Damage in the Murine Spinal Cord Injury Model

AOYAMA Takeshi,HIDA Kazutoshi,KURODA Satoshi,SEKI Toshitaka,YANO Shunsuke,SHICHINOHE Hideo,IWASAKI Yoshinobu
Neurologia medico-chirurgica 48(12), 539-545, 2008-12-15
… In situ detection of superoxide in the injured cord was carried out using the superoxide-sensitive dye dihydroethidium (DHE) staining technique. … Semi-quantitative measurements of red fluorescence emitted from DHE revealed that the superoxide concentration increased in the lesion periphery at 1 and 3 hours after the insult, and that pretreatment with edaravone significantly inhibited the increase of superoxide concentration in the lesion periphery at both time points (p<0.0001). …
NAID 110007008459

Ginsenoside Rb1 Inhibits Tumor Necrosis Factor-α-Induced Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells(Pharmacology)

Chai Hui,Wang Qiuyan,Huang Lifeng [他],XIE Tian,FU Yan
Biological & pharmaceutical bulletin 31(11), 2050-2056, 2008-11-01
… Dihydroethidium (DHE) was used to demonstrate in situ levels of superoxide production. …
NAID 110006968086

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