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- 1. 薬理ゲノム学の概要 overview of pharmacogenomics
- 2. アゾールの薬理学 pharmacology of azoles
- 3. 薬と肝臓：代謝および肝障害の機序 drugs and the liver metabolism and mechanisms of injury
- 4. 副腎ステロイド生合成 adrenal steroid biosynthesis
- 5. まれな先天性副腎過形成 uncommon congenital adrenal hyperplasias
English Journal
- Assessing the effects of Awba dam sediment (Nigeria) on the steroidogenesis of H295R cells using different extraction methods.
- Natoli L, Luci G, Mennillo E, Adeogun AO, Arukwe A.
- The Science of the total environment. 2019 Feb;650(Pt 1)121-131.
- In the present study, H295R human cells were used to investigate the endocrine disruptor potential of three different sediments extracts taken from a Nigerian tropical freshwater dam (Awba Dam), using three extraction methods that allowed a selective consideration of contaminants based on their bind
- PMID 30196212
- Effect of Intravenous Fluid Volumes on the Adrenal Glucocorticoid Response After Burn Injury in Swine.
- Gómez BI, He C, Chao T, Dubick MA, Burmeister DM.
- Journal of burn care & research : official publication of the American Burn Association. 2018 Aug;39(5)652-660.
- Severe thermal injury induces metabolic and physiological stress, prompting a disruption in the hypothalamic-pituitary-adrenal axis. The objective of this study was to evaluate potential confounding effects of Lactated Ringer's (LR) resuscitation on adrenal damage and cortisol production following b
- PMID 29757442
- Organotin exposure stimulates steroidogenesis in H295R Cell via cAMP pathway.
- Yan X, He B, Liu L, Qu G, Shi J, Liao C, Hu L, Jiang G.
- Ecotoxicology and environmental safety. 2018 Jul;156()148-153.
- Organotin compounds (OTs) are used in a range of industrial products, such as antifouling paints, agricultural pesticides and stabilizers. Owing to potential endocrine-disrupting effects, human exposure to such compounds is a concern. Nevertheless, little is known about the adverse effect of OTs on
- PMID 29549738
Japanese Journal
- Effect of Polyphenols on Production of Steroid Hormones from Human Adrenocortical NCI-H295R Cells
- Hasegawa Eri,Nakagawa Saori,Sato Momoe
- Biological & pharmaceutical bulletin 36(2), 228-237, 2013-02
- NAID 40019558450
- マススクリーニングで発見された非古典型21水酸化酵素欠損症の遺伝子解析 (特集 小児内分泌学の進歩2009)
- 勝又 規行,品川 隆,田苗 綾子
- ホルモンと臨床 57(12), 1017-1020, 2009-12
- NAID 40017371608
- H62L mutation of CYP21A2 identified in the non-classical form of 21-Hydroxylase Deficiency
- NAGASAKI K
- Clin Pediatr Endocrinol 18, 111-113, 2009
- NAID 50007411618
Related Links
- CYTOCHROME P450, SUBFAMILY XXIA, POLYPEPTIDE 2 CYTOCHROME P450, SUBFAMILY XXI; CYP21 STEROID CYTOCHROME P450 21-HYDROXYLASE; P450C21 21-HYDROXYLASE B ... White et al. (1986) found that cDNA corresponding to 21-hydroxylase is 2 kb long.
- The CYP21A2 gene provides instructions for making an enzyme called 21-hydroxylase, which is part of the cytochrome P450 family of enzymes. Cytochrome P450 enzymes are involved in many processes in the body ...
Related Pictures
★リンクテーブル★
| リンク元 | 「副腎皮質ホルモン」「21ヒドロキシラーゼ」 |
「副腎皮質ホルモン」
- 英
- adrenocortical hormone
- 同
- 副腎皮質ステロイド adrenocorticoids
- 関
- 副腎皮質刺激ホルモン放出ホルモン、副腎皮質刺激ホルモン
- ステロイド
- 関
- 副腎、副腎皮質、ステロイド、コルチコステロイド、ステロイドホルモン、コルチコイド。副腎皮質ホルモン剤
種類(主要なもののみ)
- 網状層から分泌される。アンドロステンジオン
臨床関連
- 21-hydroxylaseが正常に機能しないことにより生じる (L.320)
薬理学
副腎皮質から分泌されるホルモン (SP.895)
| 名称 | 血漿濃度 (ng/ml) |
1日分泌量 (mg/day) | |
| 糖質コルチコイド | コルチゾール | 40～180 | 15～20 |
| コルチコステロン | 2～6 | 2～5 | |
| 鉱質コルチコイド | アルドステロン | 0.05～0.20 | 0.05～0.15 |
| 11-DOC | 0.05～0.30 | 0.10～0.20 | |
| 副腎アンドロジェン | DHEA | 2～8 | 7～15 |
| DHEA-S | 1～4 | ||
| アンドロステンジオン | 1～2 | 2～3 | |
「21ヒドロキシラーゼ」
- 英
- 21-hydroxylase
- 同
- ステロイド21水酸化酵素 ステロイド21-水酸化酵素 steroid 21-hydroxylase、21水酸化酵素、21 beta-hydroxylase、ステロイド21-モノオキシゲナーゼ steroid 21-monooxygenase、シトクロムP-450C21 cytochrome P-450C21、CYP21