クリチディア・ファシキュラータ
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/08 03:06:16」(JST)
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| Crithidia |
| Scientific classification |
| Domain: |
Eukaryota |
| (unranked): |
Excavata |
| Phylum: |
Euglenozoa |
| Class: |
Kinetoplastea |
| Order: |
Trypanosomatida |
| Genus: |
Crithidia |
| Species: |
fasciculata |
Crithidia fasciculata is a species of parasitic protist. C. fasciculata, like other species of Crithidia have a single host life cycle with insect host, in the case of C. fasciculata this is the mosquito. C. fasciculata have low host species specificity and can infect many species of mosquito.
Life cycle
C. fasciculata is found in two morphologically different life cycle stages - the free swimming choanomastigote form, which has a long external flagellum for motility, and the attached, immotile, amastigote form in the mosquito gut. Amastigotes excreted in the faeces contaminates the mosquito habitat, contamination of flowers during nectar feeding is common.
Transmission of C fasciculata primarily occurs when amastigotes, washed into standing water, are ingested by mosquito larvae. The amastigotes are typically found in the rectum of a larva. Each molt of the larva results in loss of infection, but it is generally quickly re-acquired from the environment by ingestion of more amastigotes. When the fourth instar larva pupates the amastigote infection is maintained in the gut through metamorphosis giving rise to an infected adult mosquito.
Role in research
C. fasciculata is an example of a non-human infective trypanosomatid and is related to several human parasites, including Trypanosoma brucei (which causes African trypanosomiasis) and Leishmania spp. (which cause Leishmaniasis). C. fasciculata is often used as a model organism in research into trypanosomatid biology that may then be applied to understanding the biology of the human infective species.
As is typical of the trypanosomatids, but unlike many other protists, C. fasciculata possess one mitochondrion. The mitochondrial DNA is found in a single structure, the kinetoplast, at the base of the single flagellum. As is common with parasitic species C. fasciculata requires a high nutrient content broth (including heme and folic acid) in which to grow under laboratory conditions.
References
Oliver Wilford Olsen (1986). Animal parasites: their life cycles and ecology. Mineola, N.Y: Dover. ISBN 0-486-65126-6.
UpToDate Contents
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English Journal
- Lineage-specific activities of a multipotent mitochondrion of trypanosomatid flagellates.
- Škodová-Sveráková I1, Verner Z, Skalický T, Votýpka J, Horváth A, Lukeš J.
- Molecular microbiology.Mol Microbiol.2015 Apr;96(1):55-67. doi: 10.1111/mmi.12920. Epub 2015 Jan 30.
- Trypanosomatids are a very diverse group composed of monoxenous and dixenous parasites belonging to the excavate class Kinetoplastea. Here we studied the respiration of five monoxenous species (Blechomonas ayalai, Herpetomonas muscarum, H. samuelpessoai, Leptomonas pyrrhocoris and Sergeia podlipae
- PMID 25557487
- Mutations in the Predicted Active Site of Xanthomonas oryzae pv. oryzae XopQ Differentially Affect Virulence, Suppression of Host Innate Immunity, and Induction of the HR in a Nonhost Plant.
- Gupta MK, Nathawat R, Sinha D, Haque AS, Sankaranarayanan R, Sonti RV.
- Molecular plant-microbe interactions : MPMI.Mol Plant Microbe Interact.2015 Feb;28(2):195-206. doi: 10.1094/MPMI-09-14-0288-R.
- Xanthomonas oryzae pv. oryzae, the bacterial blight pathogen of rice, secretes a number of effectors through a type 3 secretion system. One of these effectors, called XopQ, is required for virulence and suppression of rice innate immune responses induced by the plant cell-wall-degrading enzyme lipas
- PMID 25353365
- The effect of tunicamycin on the glucose uptake, growth, and cellular adhesion in the protozoan parasite Crithidia fasciculata.
- Rojas R1, Segovia C, Trombert AN, Santander J, Manque P.
- Current microbiology.Curr Microbiol.2014 Oct;69(4):541-8. doi: 10.1007/s00284-014-0620-x. Epub 2014 Jun 4.
- Crithidia fasciculata represents a very interesting model organism to study biochemical, cellular, and genetic processes unique to members of the family of the Trypanosomatidae. Thus, C. fasciculata parasitizes several species of insects and has been widely used to test new therapeutic strategies ag
- PMID 24894907
Japanese Journal
- Purification of Terminal Uridylyltransferase from the Crithidia Kinetoplast-Mitochondrion (RESEARCH FACILITY OF NUCLEIC ACIDS)
- A unique cascade of oxidoreductases catalyses trypanothione-dependent peroxide metabolism in Crithidia fasciculata
- The 5' Terminal Region of the Apocytochrome b Transcript in Crithidia fasciculata is Successively Edited by Two Guide RNAs in the 3' to 5' Direction (NUCLEIC ACID RESEARCH FACILITY)
Related Links
- Crithidia fasciculata ATCC ® 12857 Designation: Wallace Isolation: mosquito, Culex pipiens, St. Paul, MN, 1942 ... Year of Origin
- Crithidia fasciculata are a species of parasitic protists, often found in insects, and are often used as a model organism in research that may then be applied to Trypanosoma brucei. Unlike many other protists, C. fasciculata contain ...
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