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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/09 15:13:21」(JST)

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Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure.^[1]^[2] It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these is available in the United States as of May 2010.^[3]

Of the eight possible stereoisomers, only the all-(S)-form is medically viable.^{[citation needed]}

Synthesis

Cilazapril synthesis^[4]

References

^ Szucs, T. (1991). "Cilazapril. A review". Drugs. 41 Suppl 1: 18–24. doi:10.2165/00003495-199100411-00005. PMID 1712267.
^ Jasek, W, ed. (2007). Austria-Codex (in German) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4.
^ Drugs.com: Cilazapril
^ Attwood, M. R.; Hassall, C. H.; Kröhn, A.; Lawton, G.; Redshaw, S. (1986). "The design and synthesis of the Angiotensin Converting Enzyme inhibitor Cilazapril and related bicyclic compounds". Journal of the Chemical Society, Perkin Transactions 1: 1011. doi:10.1039/P19860001011.

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1. 高血圧性腎硬化症の臨床的特徴、診断および治療 clinical features diagnosis and treatment of hypertensive nephrosclerosis

English Journal

Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS.

Lalović B1, Đurkić T1, Vukčević M2, Janković-Častvan I1, Kalijadis A3, Laušević Z3, Laušević M1.
Environmental science and pollution research international.Environ Sci Pollut Res Int.2017 Sep;24(25):20784-20793. doi: 10.1007/s11356-017-9748-0. Epub 2017 Jul 17.
PMID 28718026

Multicriteria Optimization Methodology in Stability-Indicating Method Development of Cilazapril and Hydrochlorothiazide.

Šljivic J1, Protic A1, Otaševic B1, Golubovic J1, Zecevic M1, Krmar J1.
Journal of chromatographic science.J Chromatogr Sci.2017 Jul 1;55(6):625-637. doi: 10.1093/chromsci/bmx018.
PMID 28334985

Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats.

Ma H1,2, Kong J3, Wang YL1,2, Li JL1,2, Hei NH1,2, Cao XR1,2, Yang JJ3, Yan WJ3, Liang WJ3, Dai HY4, Dong B1,2.
Oncotarget.Oncotarget.2017 Apr 11;8(15):24548-24563. doi: 10.18632/oncotarget.15595.
PMID 28445944

Japanese Journal

アンギオテンシン変換酵素阻害剤の増量が有効であった拡張型心筋症の1例

日本小児科学会雑誌 115(3), 629-634, 2011-03-01
NAID 10029385189

Combination of an ACE Inhibitor and Indapamide Improves Blood Pressure Control, but Attenuates the Beneficial Effects of ACE Inhibition on Plasma Adiponectin in Patients With Essential Hypertension

Circulation journal : official journal of the Japanese Circulation Society 73(12), 2282-2287, 2009-11-20
NAID 10025938377

Hyperbaric oxygen treatment augments the efficacy of cilazapril and simvastatin regimens in an experimental nephrotic syndrome model

Clinical and experimental nephrology 12(2), 110-118, 2008-04-01
NAID 10025352104

「アンジオテンシン変換酵素阻害薬」

Cilazapril
Names
	IUPAC name (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
Identifiers
CAS Number	88768-40-5
ChEMBL	ChEMBL515606
ChemSpider	50831
DrugBank	DB01340
IUPHAR/BPS	6459
Jmol interactive 3D	Image
KEGG	D07699
PubChem	56330; 40467985 (1R,9S)-(2S)-butylamino isomer
UNII	8Q9454114Q
	InChI InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28) Key: HHHKFGXWKKUNCY-UHFFFAOYSA-N ;
	SMILES CCOC(=O)C(CCc1ccccc1)NC1CCCN2CCCC(N2C1=O)C(O)=O ;
Properties
Chemical formula	C22H31N3O5
Molar mass	417.51 g·mol−1
log P	2.212
Acidity (pKa)	2.285
Basicity (pKb)	11.712
Pharmacology
ATC code	C09AA08
Legal status	UK: POM (Prescription only);
Routes of; administration	Oral
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

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英: angiotensin-converting enzyme inhibitor angiotensin converting enzyme inhibitor , ACE inhibitor, ACEI
同: アンジオテンシン変換酵素阻害剤アンギオテンシン変換酵素阻害薬アンギオテンシン変換酵素阻害剤アンジオテンシン転換酵素阻害薬、ACE阻害薬 ACE阻害剤 ACE inhibitor、アンギオテンシン変換酵素拮抗薬, アンギオテンシン変換酵素拮抗薬, angiotensin-converting enzyme antagonist
関: アンジオテンシン, アンジオテンシン転換酵素 ACE, 1型アンジオテンシンII受容体拮抗薬アンジオテンシンII受容体拮抗薬 ARB