For other uses of the word mumps, see Mumps (disambiguation).
| Mumps |
| Synonyms |
Epidemic parotitis |
|
| Child with mumps |
| Specialty |
Infectious disease |
| Symptoms |
Fever, muscle pain, headache, feeling tired, painful swelling of the parotid gland[1] |
| Complications |
Meningitis, pancreatitis, deafness, infertility (males)[1] |
| Usual onset |
~17 days after exposure[2][1] |
| Duration |
7–10 days[2][1] |
| Causes |
Mumps virus[2] |
| Diagnostic method |
Viral culture, antibodies in the blood[2] |
| Prevention |
Mumps vaccine[1] |
| Treatment |
Supportive[3] |
| Medication |
Pain medication, intravenous immunoglobulin[4] |
| Prognosis |
1 per 10,000 die[1] |
| Frequency |
More common in the developing world[5] |
|
[edit on Wikidata]
|
Mumps is a viral disease caused by the mumps virus.[2] Initial signs and symptoms often include fever, muscle pain, headache, and feeling tired.[1] This is then usually followed by painful swelling of one or both parotid salivary glands.[4] Symptoms typically occur 16 to 18 days after exposure and resolve after seven to ten days.[2][1] Symptoms in adults are often more severe than in children.[1] About a third of people have mild or no symptoms.[1] Complications may include meningitis (15 percent), pancreatitis (four percent), permanent deafness, and testicular inflammation which uncommonly results in infertility.[1] Women may develop ovarian swelling but this does not increase the risk of infertility.[4]
Mumps is highly contagious and spreads rapidly among people living in close quarters.[6] The virus is transmitted by respiratory droplets or direct contact with an infected person.[2] Only humans get and spread the disease.[1] People are infectious to each other from about seven days before the start of symptoms to about eight days after.[7] Once an infection has run its course, a person is typically immune for life.[1] Reinfection is possible but the ensuing infection tends to be mild.[8] Diagnosis is usually suspected due to parotid swelling and can be confirmed by isolating the virus on a swab of the parotid duct.[2] Testing for IgM antibodies in the blood is simple and may be useful; however, it can be falsely negative in those who have been immunized.[2]
Mumps is preventable by two doses of the mumps vaccine. Most of the developed world includes it in their immunization programs, often in combination with measles, rubella, and varicella vaccine.[1] Countries that have low immunization rates may see an increase in cases among older age groups and thus worse outcomes.[4] There is no specific treatment.[1] Efforts involve controlling symptoms with pain medication such as paracetamol (acetaminophen). Intravenous immunoglobulin may be useful in certain complications.[4] Hospitalization may be required if meningitis or pancreatitis develops.[6][8] About one per ten thousand people who are infected die.[1]
Without immunization about 0.1 percent to one percent of the population are affected per year. Widespread vaccination has resulted in a more than 90 percent decline in rates of disease. Mumps is more common in the developing world where vaccination is less common.[5] Outbreaks, however, may still occur in a vaccinated population.[4] Before the introduction of a vaccine, mumps was a common childhood disease worldwide. Larger outbreaks of disease would typically occur every two to five years. Children between the ages of five and nine were most commonly affected.[1] Among immunized populations often those in their early 20s are affected.[4] Around the equator it often occurs all year round while in the more northerly and southerly regions of the world it is more common in the winter and spring.[1] Painful swelling of the parotid glands and testicles was described by Hippocrates in the 5th century BCE.[2]
Contents
- 1 Signs and symptoms
- 2 Cause
- 3 Diagnosis
- 4 Prevention
- 5 Management
- 6 Epidemiology
- 7 References
- 8 External links
Signs and symptoms
Mumps is usually preceded by a set of prodromal symptoms including low-grade fever, headache, and malaise.[3] This is followed by progressive swelling of one or both parotid glands.[3] Parotid gland swelling usually lasts about one week.[3] Other symptoms of mumps can include dry mouth, sore face and/or ears and some patients find it difficult to talk.[9] A vaccine has been available since the 1960s.[1]
Complications
- Painful testicular inflammation develops in 15–40 percent of men who have completed puberty and contract the mumps virus.[3] This testicular inflammation is generally one-sided (both testicles are swollen in 15–30 percent of mumps orchitis cases) and typically occurs about 10 days after the parotid gland inflamed.[3] Testicular swelling has been documented as late as six weeks after parotid gland swelling.[3] Decreased fertility is an uncommon consequence of testicular inflammation from mumps and infertility is rare.[3]
- Studies have reached differing conclusions regarding whether or not infection with the mumps virus during pregnancy leads to an increased rate of spontaneous abortion[4]
- Before vaccination approximately 10 percent of cases of aseptic meningitis were due to mumps.[10] The symptoms would generally resolve within 10 days.[10] Infection of the brain itself (encephalitis) occurs in between 0.02% and 0.3% of cases.[10]
- Ovarian inflammation occurs in about five percent of adolescent and adult females.[8]
- Acute pancreatic inflammation in about four percent of cases, manifesting as abdominal pain and vomiting
- Brain inflammation (very rare, and fatal in about one percent of the cases when it occurs)[8]
- Profound (91 dB or more) but rare sensorineural hearing loss, which can be uni- or bilateral. Acute unilateral deafness occurs in about 0.005 percent of cases.[8]
Cause
The mumps virus is an enveloped single-stranded, linear negative-sense RNA virus of the Rubulavirus genus and Paramyxovirus family. The genome consists of 15,384 bases encoding nine proteins. Proteins involved in viral replication are the nucleoprotein, phosphoprotein, and polymerase protein while the genomic RNA forms the ribonucleocapsid.[4][3][11] Humans are the only natural host for the virus.
Mumps is spread from person to person through contact with respiratory secretions, such as saliva from an infected person.[3] When an infected person coughs or sneezes, the droplets aerosolize and can enter the eyes, nose, or mouth of another person. Mumps can also be spread by sharing eating utensils or cups.[12] The virus can also survive on surfaces and then be spread after contact in a similar manner. A person infected with mumps is contagious from approximately seven days before the onset of symptoms until about eight days after symptoms start.[7] The incubation period (time until symptoms begin) can be from 12–25 days, but is typically 16–18 days.[7] 20-40 percent of persons infected with the mumps virus do not show symptoms, so it is possible to be infected and spread the virus without knowing it.[7]
Diagnosis
During an outbreak, a diagnosis can be made by determining recent exposure and parotitis. However, when the disease incidence is low, other infectious causes of parotitis should be considered such as HIV, coxsackievirus, and influenza. Some viruses such as enteroviruses may cause aseptic meningitis that is very clinically similar to mumps.[11]
A physical examination confirms the presence of the swollen glands. Usually, the disease is diagnosed on clinical grounds, and no confirmatory laboratory testing is needed. If there is uncertainty about the diagnosis, a test of saliva or blood may be carried out; a newer diagnostic confirmation, using real-time nested polymerase chain reaction (PCR) technology, has also been developed.[13] As with any inflammation of the salivary glands, the serum level of the enzyme amylase is often elevated.[14][15]
Prevention
The most common preventative measure against mumps is a vaccination with a mumps vaccine, invented by American microbiologist Maurice Hilleman at Merck.[16][17] The vaccine may be given separately or as part of the MMR immunization vaccine that also protects against measles and rubella. In the US, MMR is now being supplanted by MMRV, which adds protection against chickenpox (varicella, HHV3). The WHO (World Health Organization) recommends the use of mumps vaccines in all countries with well-functioning childhood vaccination programmes. In the United Kingdom it is routinely given to children at age 13 months with a booster at 3–5 years (preschool) This confers lifelong[citation needed] immunity. The American Academy of Pediatrics recommends the routine administration of MMR vaccine at ages 12–15 months and at 4–6 years.[18] In some locations, the vaccine is given again between four and six years of age, or between 11 and 12 years of age if not previously given. The efficacy of the vaccine depends on the strain of the vaccine, but is usually around 80 percent.[19][20] The Jeryl Lynn strain is most commonly used in developed countries but has been shown to have reduced efficacy in epidemic situations. The Leningrad-Zagreb strain commonly used in developing countries appears to have superior efficacy in epidemic situations.[21]
Because of the outbreaks within college and university settings, many governments have established vaccination programs to prevent large-scale outbreaks. In Canada, provincial governments and the Public Health Agency of Canada have all participated in awareness campaigns to encourage students ranging from grade one to college and university to get vaccinated.[22]
Some anti-vaccine activists protest against the administration of a vaccine against mumps, claiming that the attenuated vaccine strain is harmful, and/or that the wild disease is beneficial. There is no evidence whatsoever to support the claim that the wild disease is beneficial, or that the MMR vaccine is harmful. Claims have been made that the MMR vaccine is linked to autism and inflammatory bowel disease, including one study by Andrew Wakefield.[23][24] The paper was discredited and retracted in 2010 and Wakefield was later stripped of his license after his work was found to be an "elaborate fraud".[25] Also, subsequent studies indicate no link between vaccination with the MMR and autism.[26] Since the dangers of the disease are well known, and the dangers of the vaccine are quite minimal, most doctors recommend vaccination.
The WHO, the American Academy of Pediatrics, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention, the American Academy of Family Physicians, the British Medical Association and the Royal Pharmaceutical Society of Great Britain currently recommend routine vaccination of children against mumps. The British Medical Association and Royal Pharmaceutical Society of Great Britain had previously recommended against general mumps vaccination, changing that recommendation in 1987.
Before the introduction of the mumps vaccine, the mumps virus was the leading cause of viral meningoencephalitis in the United States. However, encephalitis occurs rarely (less than two per 100,000).[27] In one of the largest studies in the literature, the most common symptoms of mumps meningoencephalitis were found to be fever (97 percent), vomiting (94 percent) and headache (88.8 percent).[28] The mumps vaccine was introduced into the United States in December 1967: since its introduction there has been a steady decrease in the incidence of mumps and mumps virus infection. There were 151,209 cases of mumps reported in 1968. From 2001 to 2008, the case average was only 265 per year, excluding an outbreak of less than 6000 cases in 2006 attributed largely to university contagion in young adults.[29][30]
Management
The treatment of mumps is supportive.[3] Symptoms may be relieved by the application of intermittent ice or heat to the affected neck/testicular area and by acetaminophen for pain relief.[3] Warm saltwater gargles, soft foods, and extra fluids may also help relieve symptoms. Acetylsalicylic acid (aspirin) is not used to treat children due to the risk of Reye's syndrome.[31]
There is no effective post-exposure recommendation to prevent secondary transmission, nor is the post-exposure use of vaccine or immunoglobulin effective.[32]
Mumps is considered most contagious in the five days after the onset of symptoms, and isolation is recommended during this period. In someone who has been admitted to the hospital, standard and droplet precautions are needed. People who work in healthcare cannot work for five days.[7]
Epidemiology
See also: List of modern mumps outbreaks
In the United States there are typically between a couple of hundred and a couple of thousand cases a year.[33]
References
- ^ a b c d e f g h i j k l m n o p q r s "Mumps virus vaccines." (PDF). Weekly epidemiological record. 82 (7): 49–60. 16 February 2007. PMID 17304707.
- ^ a b c d e f g h i j Atkinson, William (May 2012). Mumps Epidemiology and Prevention of Vaccine-Preventable Diseases (12 ed.). Public Health Foundation. pp. Chapter 14. ISBN 978-0-9832631-3-5.
- ^ a b c d e f g h i j k l Davis NF, McGuire BB, Mahon JA, Smyth AE, O'Malley KJ, Fitzpatrick JM (April 2010). "The increasing incidence of mumps orchitis: a comprehensive review". BJU International. 105 (8): 1060–5. PMID 20070300. doi:10.1111/j.1464-410X.2009.09148.x.
- ^ a b c d e f g h i Hviid A, Rubin S, Mühlemann K (March 2008). "Mumps". The Lancet. 371 (9616): 932–44. PMID 18342688. doi:10.1016/S0140-6736(08)60419-5.
- ^ a b Junghanss, Thomas (2013). Manson's tropical diseases. (23rd ed.). Oxford: Elsevier/Saunders. p. 261. ISBN 978-0-7020-5306-1.
- ^ a b Gupta, RK; Best, J; MacMahon, E (14 May 2005). "Mumps and the UK epidemic 2005.". BMJ (Clinical research ed.). 330 (7500): 1132–5. PMC 557899 . PMID 15891229. doi:10.1136/bmj.330.7500.1132.
- ^ a b c d e Kutty PK, Kyaw MH, Dayan GH, Brady MT, Bocchini JA, Reef SE, Bellini WJ, Seward JF (15 June 2010). "Guidance for isolation precautions for mumps in the United States: a review of the scientific basis for policy change". Clinical Infectious Diseases. 50 (12): 1619–28. PMID 20455692. doi:10.1086/652770.
- ^ a b c d e Sen2008 SN (2008). "Mumps: a resurgent disease with protean manifestations". Med J Aust. 189 (8): 456–9. PMID 18928441.
- ^ Kasper DL; Braunwald E; Fauci AS; Hauser SL; Longo DL; Jameson JL; Isselbacher KJ; Eds. (2011). "194. Mumps". Harrison's Principles of Internal Medicine (18th ed.). McGraw-Hill Professional. ISBN 978-0-07-174889-6.
- ^ a b c "Pinkbook | Mumps | Epidemiology of Vaccine Preventable Diseases | CDC". www.cdc.gov.
- ^ a b Longo, Dan L.; Kasper, Dennis L.; Jameson, J. Larry; Fauci, Anthony S.; Hauser, Stephen L.; Loscalzo, Joseph, eds. (2012). Harrison's principles of internal medicine. (18th ed.). New York: McGraw-Hill. ISBN 978-0-07-174889-6.
- ^ "Mumps | Transmission | CDC". www.cdc.gov. Retrieved 18 April 2016.
- ^ Krause CH, Eastick K, Ogilvie MM (November 2006). "Real-time PCR for mumps diagnosis on clinical specimens--comparison with results of conventional methods of virus detection and nested PCR". J. Clin. Virol. 37 (3): 184–9. PMID 16971175. doi:10.1016/j.jcv.2006.07.009.
- ^ Amylase: The Test, Lab Tests Online UK
- ^ Skrha J, Stĕpán J, Sixtová E (October 1979). "Amylase isoenzymes in mumps". Eur. J. Pediatr. 132 (2): 99–105. PMID 499265. doi:10.1007/BF00447376.
- ^ Offit PA (2007). Vaccinated: One Man's Quest to Defeat the World's Deadliest Diseases. Washington, DC: Smithsonian. ISBN 0-06-122796-X.
- ^ Buynak EB; Weibel RE; Whitman JE Jr; Stokes J Jr; Hilleman MR (March 1969). Combined live measles, mumps, and rubella virus vaccines. JAMA. 207. pp. 2259–62. PMID 5818433.
- ^ MMR Vaccine (PDF) (PDF), Vaccine Information Statement, United States: Centers for Disease Control and Prevention, 20 April 2012, p. 1, retrieved 22 February 2013
- ^ Schlegel M, Osterwalder JJ, Galeazzi RL, Vernazza PL (1999). "Comparative efficacy of three mumps vaccines during disease outbreak in eastern Switzerland: cohort study". BMJ. 319 (7206): 352. PMC 32261 . PMID 10435956. doi:10.1136/bmj.319.7206.352.
- ^ "Summary". WHO: Mumps vaccine. Archived from the original on 15 April 2006. Retrieved 18 April 2006.
- ^ Peltola H, Kulkarni PS, Kapre SV, Paunio M, Jadhav SS, Dhere RM (August 2007). "Mumps outbreaks in Canada and the United States: time for new thinking on mumps vaccines". Clin. Infect. Dis. 45 (4): 459–66. PMID 17638194. doi:10.1086/520028.
- ^ Table 2: Provincial and Territorial recommendations for mumps-containing immunization, 2007 Archived 7 December 2008 at the Wayback Machine., Information on Outbreaks of Mumps In Canada – Information for Health Professionals, Public Health Agency Canada
- ^ "Autism and Andrew Wakefield". Immunization. American Academy of Pediatrics. 30 October 2013. Archived from the original on 5 January 2014.
- ^ "Causes of Autism". aboutHealth. about.com.
- ^ Cohen, Elizabeth; Falco, Miriam (5 January 2011). "Retracted autism study an 'elaborate fraud,' British journal finds". CNN. Retrieved 16 May 2011.
- ^ Demicheli V, Rivetti A, Debalini MG, Di Pietrantonj C (2012). "Vaccines for measles, mumps and rubella in children". Cochrane Database Syst Rev. 2: CD004407. PMID 22336803. doi:10.1002/14651858.CD004407.pub3.
- ^ Atkinson W; Humiston S; Wolfe C; Nelson R, eds. (2006). Epidemiology and Prevention of Vaccine-Preventable Diseases (9th ed.). Centers for Disease Control and prevention. Fulltext. [dead link]
- ^ Kanra G, Isik P, Kara A, Cengiz AB, Seçmeer G, Ceyhan M (2004). "Complementary findings in clinical and epidemiologic features of mumps and mumps meningoencephalitis in children without mumps vaccination". Pediatr Int. 46 (6): 663–8. PMID 15660864. doi:10.1111/j.1442-200x.2004.01968.x.
- ^ McNabb SJ, Jajosky RA, Hall-Baker PA, Adams DA, Sharp P, Worshams C, Anderson WJ, Javier AJ, Jones GJ, Nitschke DA, Rey A, Wodajo MS (March 2008). "Summary of notifiable diseases--United States, 2006". MMWR Morb. Mortal. Wkly. Rep. 55 (53): 1–92. PMID 18354375. Retrieved 13 November 2009.
- ^ Susan Brink (14 April 2008), "Mumps despite shots", Los Angeles Times, retrieved 22 February 2013
- ^ "Mumps – National Library of Medicine – Pubmed Health". Retrieved 14 January 2015.
- ^ "Mumps Clinical Information – Minnesota Dept. of Health".
- ^ "Mumps | Cases and Outbreaks | CDC". www.cdc.gov. Retrieved 21 April 2017.
External links
| Classification |
V · T · D
- ICD-10: B26
- ICD-9-CM: 072
- MeSH: D009107
- DiseasesDB: 8449
|
| External resources |
- MedlinePlus: 001557
- eMedicine: emerg/324 emerg/391 ped/1503
- Patient UK: Mumps
|
|
Wikiquote has quotations related to: Mumps |
|
Wikimedia Commons has media related to Mumps. |
- NHS.uk – Encyclopedia – 'NHS Direct Online Health Encyclopaedia: Mumps', National Health Service (UK)
- WHO.int – "Immunization, Vaccines and Biologicals: Mumps vaccine", World Health Organisation
- MicrobiologyBytes: Paramyxoviruses"
- Collection of information from the CDC concerning mumps
- Public Health Agency of Canada – Public Health Agency of Canada Vaccination Campaigns
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Oral and maxillofacial pathology (K00–K06, K11–K14, 520–525, 527–529)
|
|
Lips
|
- Cheilitis
- Actinic
- Angular
- Plasma cell
- Cleft lip
- Congenital lip pit
- Eclabium
- Herpes labialis
- Macrocheilia
- Microcheilia
- Nasolabial cyst
- Sun poisoning
- Trumpeter's wart
|
|
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Tongue
|
- Ankyloglossia
- Black hairy tongue
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- Cunnilingus tongue
- Fissured tongue
- Foliate papillitis
- Glossitis
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- Median rhomboid glossitis
- Transient lingual papillitis
- Glossoptosis
- Hypoglossia
- Lingual thyroid
- Macroglossia
- Microglossia
- Rhabdomyoma
|
|
|
Palate
|
- Bednar's aphthae
- Cleft palate
- High-arched palate
- Palatal cysts of the newborn
- Inflammatory papillary hyperplasia
- Stomatitis nicotina
- Torus palatinus
|
|
|
Oral mucosa – Lining of mouth
|
- Amalgam tattoo
- Angina bullosa haemorrhagica
- Behçet's disease
- Bohn's nodules
- Burning mouth syndrome
- Candidiasis
- Condyloma acuminatum
- Darier's disease
- Epulis fissuratum
- Erythema multiforme
- Erythroplakia
- Fibroma
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- Fordyce spots
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- Hand, foot and mouth disease
- Hereditary benign intraepithelial dyskeratosis
- Herpangina
- Herpes zoster
- Intraoral dental sinus
- Leukoedema
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- Linea alba
- Lupus erythematosus
- Melanocytic nevus
- Melanocytic oral lesion
- Molluscum contagiosum
- Morsicatio buccarum
- Oral cancer
- Benign: Squamous cell papilloma
- Keratoacanthoma
- Malignant: Adenosquamous carcinoma
- Basaloid squamous carcinoma
- Mucosal melanoma
- Spindle cell carcinoma
- Squamous cell carcinoma
- Verrucous carcinoma
- Oral florid papillomatosis
- Oral melanosis
- Pemphigoid
- Pemphigus
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- Stomatitis
- Aphthous
- Denture-related
- Herpetic
- Smokeless tobacco keratosis
- Submucous fibrosis
- Ulceration
- Verruca vulgaris
- Verruciform xanthoma
- White sponge nevus
|
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Teeth (pulp, dentin, enamel)
|
- Amelogenesis imperfecta
- Ankylosis
- Anodontia
- Caries
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- Failure of eruption of teeth
- Dens evaginatus
- Dentin dysplasia
- Dentin hypersensitivity
- Dentinogenesis imperfecta
- Dilaceration
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- Ectopic enamel
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- Enamel pearl
- Fluorosis
- Fusion
- Gemination
- Hyperdontia
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- Maxillary lateral incisor agenesis
- Impaction
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- Meth mouth
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- Odontogenic tumors
- Keratocystic odontogenic tumour
- Odontoma
- Open contact
- Premature eruption
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- Pulp necrosis
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- Pulpitis
- Regional odontodysplasia
- Resorption
- Shovel-shaped incisors
- Supernumerary root
- Taurodontism
- Trauma
- Avulsion
- Cracked tooth syndrome
- Vertical root fracture
- Occlusal
- Tooth loss
- Tooth wear
- Abrasion
- Abfraction
- Acid erosion
- Attrition
|
|
|
Periodontium (gingiva, periodontal ligament, cementum, alveolus) – Gums and tooth-supporting structures
|
- Cementicle
- Cementoblastoma
- Cementoma
- Eruption cyst
- Epulis
- Pyogenic granuloma
- Congenital epulis
- Gingival enlargement
- Gingival cyst of the adult
- Gingival cyst of the newborn
- Gingivitis
- Desquamative
- Granulomatous
- Plasma cell
- Hereditary gingival fibromatosis
- Hypercementosis
- Hypocementosis
- Linear gingival erythema
- Necrotizing periodontal diseases
- Acute necrotizing ulcerative gingivitis
- Pericoronitis
- Peri-implantitis
- Periodontal abscess
- Periodontal trauma
- Periodontitis
- Aggressive
- As a manifestation of systemic disease
- Chronic
- Perio-endo lesion
- Teething
|
|
|
Periapaical, mandibular and maxillary hard tissues – Bones of jaws
|
- Agnathia
- Alveolar osteitis
- Buccal exostosis
- Cherubism
- Idiopathic osteosclerosis
- Mandibular fracture
- Microgenia
- Micrognathia
- Intraosseous cysts
- Odontogenic: periapical
- Dentigerous
- Buccal bifurcation
- Lateral periodontal
- Globulomaxillary
- Calcifying odontogenic
- Glandular odontogenic
- Non-odontogenic: Nasopalatine duct
- Median mandibular
- Median palatal
- Traumatic bone
- Osteoma
- Osteomyelitis
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- Periapical abscess
- Periapical periodontitis
- Stafne defect
- Torus mandibularis
|
|
|
Temporomandibular joints, muscles of mastication and malocclusions – Jaw joints, chewing muscles and bite abnormalities
|
- Bruxism
- Condylar resorption
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- Crossbite
- Open bite
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- Overeruption
- Overjet
- Prognathia
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- Scissor bite
- Maxillary hypoplasia
- Temporomandibular joint dysfunction
|
|
|
Salivary glands
|
- Benign lymphoepithelial lesion
- Ectopic salivary gland tissue
- Frey's syndrome
- HIV salivary gland disease
- Necrotizing sialometaplasia
- Mucocele
- Pneumoparotitis
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- Salivary gland fistula
- Salivary gland hyperplasia
- Salivary gland hypoplasia
- Salivary gland neoplasms
- Benign: Basal cell adenoma
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- Pleomorphic adenoma
- Sebaceous adenoma
- Malignant: Acinic cell carcinoma
- Adenocarcinoma
- Adenoid cystic carcinoma
- Carcinoma ex pleomorphic adenoma
- Lymphoma
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- Sclerosing polycystic adenosis
- Sialadenitis
- Parotitis
- Chronic sclerosing sialadenitis
- Sialectasis
- Sialocele
- Sialodochitis
- Sialosis
- Sialolithiasis
- Sjögren's syndrome
|
|
|
Orofacial soft tissues – Soft tissues around the mouth
|
- Actinomycosis
- Angioedema
- Basal cell carcinoma
- Cutaneous sinus of dental origin
- Cystic hygroma
- Gnathophyma
- Ludwig's angina
- Macrostomia
- Melkersson–Rosenthal syndrome
- Microstomia
- Noma
- Oral Crohn's disease
- Orofacial granulomatosis
- Perioral dermatitis
- Pyostomatitis vegetans
|
|
|
Other
|
- Eagle syndrome
- Hemifacial hypertrophy
- Facial hemiatrophy
- Oral manifestations of systemic disease
- Salivary microbiome
|
|
|
Infectious diseases – viral systemic diseases (A80–B34, 042–079)
|
| Oncovirus |
- DNA virus
- HBV
- Hepatocellular carcinoma
- HPV
- Cervical cancer
- Anal cancer
- Penile cancer
- Vulvar cancer
- Vaginal cancer
- Oropharyngeal cancer
- KSHV
- Kaposi's sarcoma
- EBV
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- Follicular dendritic cell sarcoma
- Extranodal NK/T-cell lymphoma, nasal type
- MCPyV
- Merkel-cell carcinoma
- RNA virus
- HCV
- Hepatocellular carcinoma
- Splenic marginal zone lymphoma
- HTLV-I
- Adult T-cell leukemia/lymphoma
|
| Immune disorders |
|
Central
nervous system |
Encephalitis/
meningitis |
- DNA virus
- JCV
- Progressive multifocal leukoencephalopathy
- RNA virus
- MeV
- Subacute sclerosing panencephalitis
- LCV
- Lymphocytic choriomeningitis
- Arbovirus encephalitis
- Orthomyxoviridae (probable)
- Encephalitis lethargica
- RV
- Rabies
- Chandipura virus
- Herpesviral meningitis
- Ramsay Hunt syndrome type 2
|
| Myelitis |
- Poliovirus
- Poliomyelitis
- Post-polio syndrome
- HTLV-I
- Tropical spastic paraparesis
|
| Eye |
- Cytomegalovirus
- Cytomegalovirus retinitis
- HSV
|
|
| Cardiovascular |
|
Respiratory system/
acute viral nasopharyngitis/
viral pneumonia |
| DNA virus |
- Epstein–Barr virus
- EBV infection/Infectious mononucleosis
- Cytomegalovirus
|
| RNA virus |
- IV: SARS coronavirus
- Severe acute respiratory syndrome
- V: Orthomyxoviridae: Influenzavirus A/B/C
- Influenza/Avian influenza
- V, Paramyxoviridae: Human parainfluenza viruses
- RSV
- hMPV
|
|
| Human digestive system |
| Pharynx/Esophagus |
- MuV
- Cytomegalovirus
- Cytomegalovirus esophagitis
|
Gastroenteritis/
diarrhea |
- DNA virus
- Adenovirus
- Adenovirus infection
- RNA virus
- Rotavirus
- Norovirus
- Astrovirus
- Coronavirus
|
| Hepatitis |
- DNA virus
- HBV (B)
- RNA virus
- CBV
- HAV (A)
- HCV (C)
- HDV (D)
- HEV (E)
- HGV (G)
|
| Pancreatitis |
|
|
| Urogenital |
|
