同: LSILs

WordNet

unrefined in character; "low comedy"
an air mass of lower pressure; often brings precipitation; "a low moved in over night bringing sleet and snow" (同)depression
a low level or position or degree; "the stock market fell to a new low"
used of sounds and voices; low in pitch or frequency (同)low-pitched
very low in volume; "a low murmur"; "the low-toned murmur of the surf" (同)low-toned
in a low position; near the ground; "the branches hung low"
less than normal in degree or intensity or amount; "low prices"; "the reservoir is low"
literal meanings; being at or having a relatively small elevation or upward extension; "low ceilings"; "low clouds"; "low hills"; "the sun is low"; "low furniture"; "a low bow"
level to the right gradient
a relative position or degree of value in a graded group; "lumber of the highest grade" (同)level, tier
the height of the ground on which something stands; "the base of the tower was below grade" (同)ground level
a variety of cattle produced by crossbreeding with a superior breed
the gradient of a slope or road or other surface; "the road had a steep grade"
a degree of ablaut (同)gradation
assign a grade or rank to, according to ones evaluation; "grade tests"; "score the SAT essays"; "mark homework" (同)score, mark
determine the grade of or assign a grade to
any localized abnormal structural change in a bodily part
arranged in a sequence of grades or ranks; "stratified areas of the distribution" (同)ranked, stratified
British political cartoonist (born in New Zealand) who created the character Colonel Blimp (1891-1963) (同)David Low, Sir David Low, Sir David Alexander Cecil Low

PrepTutorEJDIC

(高さ・位置が)『低い』,低い所にある / (価格・数量・程度などが)『低い』,少ない / (身分・地位などが)『低い』,卑しい / (人格・行為などが)『卑しい』,下劣な,下品な / 《補語にのみ用いて》(体が)『弱った』;元気のない,憂うつな / (供給が)不十分な;(…が)乏しい《+『in』(『on』)+『名』》 / (音・声が)低い,小さい / (生物が)下等な / 『低く』,低い所に / (価格・程度などが)『安く』,低く / 低い声(調子)で;静かに / 最低点,最低水準
(牛の)モーという鳴き声 / (牛が)モーと鳴く
《米》(小・中・高校の)『学年』(小学校から12年まで通算する) / 《おもに米》(学業の)『成績』,評点 / (位階・品質・価値などの)『階級』,『等級』 / 《米》(道路・線路などの)傾斜,勾配(こうばい)(《英》gradient) / …‘を'『等級分けする』,‘の'格づけをする / 《米》…‘の'採点をする / 〈道路など〉‘の'勾配(こうばい)をゆるくする / 等級別になる,徐々に変わる,〈色彩などが〉次第に他の色に移る
傷害,傷 / (体の組織や機能の)障害

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1. 子宮頸部細胞診：軽度扁平上皮内病変（LSIL）の評価 cervical cytology evaluation of low grade squamous intraepithelial lesions lsil
2. 子宮頚部および膣細胞診：結果の解釈 cervical and vaginal cytology interpretation of results
3. 子宮頸部上皮内腫瘍：低悪性度および高悪性度病変のマネージメント cervical intraepithelial neoplasia management of low grade and high grade lesions
4. 肛門扁平上皮内病変：診断、スクリーニング、予防、および治療 anal squamous intraepithelial lesions diagnosis screening prevention and treatment
5. 子宮頚部細胞診：高悪性度扁平上皮内病変の評価 cervical cytology evaluation of high grade squamous intraepithelial lesions hsil

English Journal

A six-year experience with anal cytology in women with HPV in the lower genital tract: Utility, limitations, and clinical correlation.

Cardinal LH1, Carballo P, Lorenzo MC, García A, Suzuki V, Tatti S, Vighi S, Díaz LB.Author information 1Gynecological Pathology Division, Department of Pathology, Hospital de Clínicas "José de San Martín," Universidad de Buenos Aires, Argentina.AbstractThis study assessed the utility and limitations of anal cytology as a screening method for women infected with human papilloma virus (HPV) in the lower genital tract. Furthermore, this study aimed to establish risk factors for pathological anal cytology/biopsy findings, the prevalence of anatomopathological lesions associated with positive anal brushings, and the frequency of concomitant lesions of the lower genital tract. A cross-sectional, retrospective, descriptive study in 207 women with HPV-associated lesions of the lower genital tract and 25 women with immunosuppression was carried out. Anal cytology, high resolution anoscopy, and biopsy of suspicious lesions were performed. In total, 232 anal brushings were performed: 184 (79.3%) were negative, 24 (10.34%) showed atypical squamous cells of undeterminated significance, 18 (7.7%) showed low-grade squamous intraepithelial lesions, and 6 (2.6%) showed high-grade squamous intraepithelial lesion. Cytohistological correlation was obtained for 70 cases. The sensitivity of anal cytology in detecting intraepithelial lesions was 70%, whereas the specificity was 93%. The sensitivity of the method for detecting high-grade lesions (84%) was higher, than that for detecting low-grade lesions (66%). The most frequently associated pathology was vulvar lesion. It is important to perform anal brushings in women who have had lower genital tract biopsies for HPV-associated lesions due to the high prevalence of anal lesions in such patients. Anal cytology is useful for detecting high-grade lesions but the sensitivity for detecting low-grade lesions is low. It is of the utmost importance to perform high-resolution anoscopy and biopsy in women with suspicious lesions in order to confirm the pathology. Diagn. Cytopathol. 2014;42:396-400. © 2013 Wiley Periodicals, Inc.
Diagnostic cytopathology.Diagn Cytopathol.2014 May;42(5):396-400. doi: 10.1002/dc.23050. Epub 2013 Oct 25.
This study assessed the utility and limitations of anal cytology as a screening method for women infected with human papilloma virus (HPV) in the lower genital tract. Furthermore, this study aimed to establish risk factors for pathological anal cytology/biopsy findings, the prevalence of anatomopath
PMID 24166879

Increased EZH2 Expression is Associated With Proliferation and Progression of Cervical Cancer and Indicates a Poor Prognosis.

Liu Y1, Liu T, Bao X, He M, Li L, Yang X.Author information 1Department of Gynecology, Qilu Hospital, Shandong University, Jinan, P.R. China.AbstractThe objective of this study was to illustrate the role of enhancer zeste homolog 2 (EZH2) overexpression in the proliferation, progression, and prognosis of cervical cancer. We detected EZH2 and Ki-67 expression levels using immunohistochemical (IHC) studies in 20 normal cervical tissues, 50 cervical intraepithelial neoplasia (including 25 low-grade intraepithelial lesions and 25 high-grade intraepithelial lesions), and 101 cervical cancer tissues. The relationships between EZH2 expression and Ki-67 expression, conventional clinicopathologic characteristics of cervical cancer, and patient outcomes were evaluated. The effect of EZH2 expression on cancer-specific survival was assessed by multivariate Cox regression analysis. Positive expression of EZH2 was detected in 10% (2/20) of the normal cervical tissues, 52% (13/25) of the low-grade squamous intraepithelial lesions, 64% (16/25) of the high-grade squamous intraepithelial lesions, and 68.3% (69/101) of the cervical cancer tissues. The expression of Ki-67 was positively correlated with EZH2 expression: 5% (1/20) in normal cervical tissues, 48% (12/25) in low-grade squamous intraepithelial lesions, 52% (13/25) in high-grade squamous intraepithelial lesions, and 57.4% (58/101) in cervical cancer tissues. Overexpression of EZH2 was adversely associated with clinical stage, histologic differentiation, infiltration depth, and lymph node metastasis (P<0.05). Patients with EZH2-positive expression showed a decreased overall survival compared with those with EZH2-negative expression (P=0.003, log-rank test). Multivariate Cox regression analysis suggested that overexpression of EZH2 was an independent predictor of poor prognosis in cervical cancer. Overexpression of EZH2 was closely associated with the carcinogenesis, proliferation, clinical and biologic behaviors, and the prognosis of cervical cancer, suggesting that it might be used as a potential predictor of prognosis in cervical cancer.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.Int J Gynecol Pathol.2014 May;33(3):218-24. doi: 10.1097/PGP.0b013e31829c6574.
The objective of this study was to illustrate the role of enhancer zeste homolog 2 (EZH2) overexpression in the proliferation, progression, and prognosis of cervical cancer. We detected EZH2 and Ki-67 expression levels using immunohistochemical (IHC) studies in 20 normal cervical tissues, 50 cervica
PMID 24681730

A 10-year retrospective analysis of the new american college of obstetricians and gynecologists' pap testing guidelines on adolescents.

Harris SC1, Cheung T, Davis J, Hiraoka M, Tauchi-Nishi P.Author information 1University of Hawaii, Honolulu, HI.AbstractINTRODUCTION: In 2012, American College of Obstetricians and Gynecologists issued new screening guidelines for cervical cancer. In these recommendations, women younger than 21 years no longer require Pap testing as a result of the effective clearance of human papillomavirus infection and infrequent progression to cancer. This study aims to examine the patterns of cervical dysplasia in our adolescents and to determine pathologies that may be missed by this new screening schedule.
Obstetrics and gynecology.Obstet Gynecol.2014 May;123 Suppl 1:180S. doi: 10.1097/01.AOG.0000447197.97678.b1.
INTRODUCTION: In 2012, American College of Obstetricians and Gynecologists issued new screening guidelines for cervical cancer. In these recommendations, women younger than 21 years no longer require Pap testing as a result of the effective clearance of human papillomavirus infection and infrequent
PMID 24770102