関: squamous

WordNet

membranous tissue covering internal organs and other internal surfaces of the body (同)epithelial_tissue

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上皮[組織](生物体の表皮・血管内壁など)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/28 19:09:28」(JST)

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In anatomy, squamous epithelium (from Latin squama, "scale") is an epithelium characterised by its most superficial layer consisting of flat, scale-like cells called squamous epithelial cells. Epithelium may be composed of one layer of these cells, in which case it is referred to as simple squamous epithelium, or it may possess multiple layers, referred to then as stratified squamous epithelium. Both types perform differing functions, ranging from nutrient exchange to protection.^{[citation needed]}

Cancers of the squamous epithelium include squamous cell carcinoma, basal cell carcinoma, and other adnexal tumors.^{[citation needed]}

Squamous epithelial cells have a polygonal appearance when viewed from above.^[1]

References[edit]

^ Kühnel, Wolfgang (2003). Color atlas of cytology, histology, and microscopic anatomy. Thieme. p. 102. ISBN 978-3-13-562404-4.

External links[edit]

Histology at KUMC epithel-epith02 Simple squamous epithelium of the glomerulus (kidney)
Diagrams of simple squamous epithelium
Histology at KUMC epithel-epith12 Stratified squamous epithelium of the vagina
Histology at KUMC epithel-epith14 Stratified squamous epithelium of the skin (thin skin)
Histology at KUMC epithel-epith15 Stratified squamous epithelium of the skin (thick skin)
Stratified squamous epithelium of the esophagus
Research News about Squamous Cell

UpToDate Contents

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1. 子宮頚部細胞診：異型扁平上皮細胞（ASC-USおよびASC-H）の評価 cervical cytology evaluation of atypical squamous cells asc us and asc h
2. 頭頸部腫瘍の病理 pathology of head and neck neoplasms
3. 外陰癌：臨床症状、診断、および病理 vulvar cancer clinical manifestations diagnosis and pathology
4. 食道癌の疫学、病理生物学、および臨床症状 epidemiology pathobiology and clinical manifestations of esophageal cancer
5. 子宮頚部細胞診：結果の解釈 cervical cytology interpretation of results

English Journal

Cells of origin of squamous epithelium, dysplasia and cancer in the head and neck region after bone marrow transplantation.

Kano Y1, Ishii H1, Konno M1, Yamasaki M2, Miyata H2, Nishikawa S1, Hamabe A1, Ogawa H1, Takahashi H2, Ohta K1, Hasegawa S1, Tanaka K2, Fukusumi T1, Otsuka M2, Kawamoto K2, Haraguchi N2, Fujimoto R3, Isobe M3, Tomita Y4, Matsuura N5, Takiguchi S2, Mori M2, Doki Y2.Author information 1Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Graduate School of Medicine, Osaka, Japan.2Department of Gastroenterological Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan.3Laboratory of Molecular and Cellular Biology, Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama University, Toyama, Japan.4Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.5Department of Functional Diagnostic Science, Osaka University, Graduate School of Medicine, Osaka, Japan.AbstractSecondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT. Previously, secondary solid tumors were considered to be recipient-derived cells because transplanted cells do not contain epithelial cells. Recently, however, not only donor‑derived epithelial cells but also donor-derived secondary solid tumors have also been reported in mice and humans. It means that circulating bone marrow-derived stem cells (BMDCs) including hematopoietic stem cells include the stem cells of many tissue types and the precancerous cells of many solid tumors. In most reports of donor-derived secondary solid tumors, however, tumors contained a low proportion of BMDC-derived epithelial cells in mixed solid tumor tissues. To our knowledge, there are only five known cases of completely donor-derived tumor tissues, i.e., four oral SCCs and a pharyngeal SCC. In this study, we analyzed five human clinical samples of solid tumors, i.e., two esophageal squamous cell carcinomas (SCCs), two oral SCCs and a tongue carcinoma. In the oral and tongue, completely donor-derived tissues were not observed, but in esophagus a completely donor-derived esophageal epidermis and SCC were observed for the first time. In addition, in another esophageal SCC patient, a completely donor-derived dysplasia region of esophageal epidermis was observed near recipient-derived SCC. This study suggests that BMDC-derived cells include the stem cells of esophageal epidermis and the precancerous cells of esophageal SCC and can differentiate into esophageal epithelium and esophageal SCC.
International journal of oncology.Int J Oncol.2014 Feb;44(2):443-50. doi: 10.3892/ijo.2013.2206. Epub 2013 Dec 3.
Secondary solid tumors that occur after hematopoietic stem cell transplantation (HSCT) are late complications of HSCT. Previously, secondary solid tumors were considered to be recipient-derived cells because transplanted cells do not contain epithelial cells. Recently, however, not only donor‑deri
PMID 24317739

Characterization of the North American beaver (Castor canadensis) papillomavirus genome.

Rogovskyy AS1, Chen Z2, Burk RD3, Bankhead T4.Author information 1Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA; Washington Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Washington State University, Pullman, WA, USA. Electronic address: artem@vetmed.wsu.edu.2Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA.3Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA; Department of Microbiology and Immunology, Epidemiology and Population Health, and Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA.4Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA; Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, USA.AbstractThe papillomaviruses comprise a large group of viruses that cause proliferations of the stratified squamous epithelium of skin and mucosa in a variety of animals. An earlier report identified a novel papillomavirus of the North American beaver, Castor canadensis (CcanPV1) that was associated with cutaneous exophytic lesions. In the current study, we determined the sequence of the complete 7435 basepair genome of CcanPV1. The genome contains an Upstream Regulatory Region located between the end of L1 and the start of E6, and seven canonical papillomavirus open reading frames encoding five early (E6, E7, E1, E2, and E4) and two late (L2 and L1) proteins. No E5 open reading frame was detected. Phylogenetic analysis of the CcanPV1 genome places the virus between the genera Kappapapillomavirus and Mupapillomavirus. Analyses of the papillomavirus genomes detected in different species of the order Rodentia indicate these viruses do not form a monophyletic clade.
Veterinary microbiology.Vet Microbiol.2014 Jan 10;168(1):214-20. doi: 10.1016/j.vetmic.2013.11.011. Epub 2013 Nov 15.
The papillomaviruses comprise a large group of viruses that cause proliferations of the stratified squamous epithelium of skin and mucosa in a variety of animals. An earlier report identified a novel papillomavirus of the North American beaver, Castor canadensis (CcanPV1) that was associated with cu
PMID 24309404

Biomarkers and molecular imaging in gastrointestinal cancers.

Xian W1, McKeon F1, Ho KY2.Author information 1Department of Medicine, National University Health System, Singapore; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut; Genome Institute of Singapore, A-STAR, Singapore; Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut.2Department of Medicine, National University Health System, Singapore. Electronic address: khek_yu_ho@nuhs.edu.sg.AbstractThe best means to improve gastrointestinal cancer survival is screening and treatment of early lesions. In esophageal adenocarcinoma, it is believed that low-grade dysplasia and perhaps even high-risk Barrett's esophagus represent the most attractive targets for achieving a cure. An issue with Barrett's esophagus is that endoscopy alone cannot distinguish Barrett's esophagus from columnar-lined epithelium or from areas of low-grade dysplasia. Much effort, therefore, has been devoted to discover molecular biomarkers of high-risk states and to develop imaging tools for detecting these biomarkers in a manner that could assist real-time in vivo targeting of sites for biopsy. The strategy we have used is to generate stem cell clones from Barrett's esophagus biopsy specimens and to compare their gene expression profiles with patient-matched stem cell clones of the esophageal squamous epithelia and gastric cardia. It is anticipated that by mining the expression data sets of these Barrett's stem cell clones, we will be able to identify unique cell surface markers of the Barrett's stem cells against which cytotoxic antibodies or aptamers can be developed and used to aid the endoscopist in identifying regions of atypia for biopsy, perform a real-time diagnosis, stratify patients during the examination, and, ultimately, direct therapy in a preemptive manner.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.Clin Gastroenterol Hepatol.2014 Jan;12(1):126-9. doi: 10.1016/j.cgh.2013.08.033. Epub 2013 Aug 23.
The best means to improve gastrointestinal cancer survival is screening and treatment of early lesions. In esophageal adenocarcinoma, it is believed that low-grade dysplasia and perhaps even high-risk Barrett's esophagus represent the most attractive targets for achieving a cure. An issue with Barre
PMID 23978343

Japanese Journal

口腔領域重層扁平上皮由来の腫瘍性病変のdermokineの発現に関する研究 (原著)

田邉陽子,羽野寛,市ノ川義美,松井毅
東京慈恵会医科大学雑誌 128(2), 73-82, 2013-03-15
NAID 120005260148

舌扁平上皮癌周囲に異型上皮を認めた症例の検討

八木原一博,出雲俊之,石井純一,桂野美貴,宮嶋大輔,柳下寿郎,岡部貞夫
日本口腔腫瘍学会誌 25(2), 21-31, 2013
要旨：われわれは1975年から2005年までに当科において生検なしで局所切除単独治療を行ったStage I，II舌扁平上皮癌一次症例128例のうち，癌周囲に異型上皮を認めた83例（65%；83/128）について臨床病理組織学的に検討した。異型上皮を口腔癌取扱い規約（第1版，2010年）により再評価したところ，口腔扁平上皮内腫瘍（OIN）が35例，口腔上皮性異形成（OED）が48例であった。83例の …
NAID 130003378723

30年の経過中に膝部の表皮嚢腫から発生した有棘細胞癌の1例

桑原広昌,内山英祐,石山誠一郎,本田耕一
Skin Cancer 28(1), 46-49, 2013
73歳，男性。初診の約30年前から右膝部に腫瘤があり，時々滲出液が出ていた。滲出液の臭いを主訴に近医皮膚科を受診し，当科を紹介された。初診時，右膝部に直径約3cmの皮下腫瘤を触知した。表層の皮膚には潰瘍を伴った小さな瘻孔を認め，圧迫により排膿がみられた。全身麻酔下に皮膚を含めて腫瘤を切除し，分層植皮にて再建した。病理組織学的所見では，異型上皮で被覆された嚢胞性病変がみられた。嚢胞壁の一部には周囲へ …
NAID 130003378165