成長ホルモン分泌不全性低身長症
WordNet
- without possessing something at the time it is contractually sold; "he made his fortune by selling short just before the crash"
- the location on a baseball field where the shortstop is stationed
- low in stature; not tall; "he was short and stocky"; "short in stature"; "a short smokestack"; "a little man" (同)little
- lacking foresight or scope; "a short view of the problem"; "shortsighted policies"; "shortsighted critics derided the plan"; "myopic thinking" (同)shortsighted, unforesightful, myopic
- at a disadvantage; "I was caught short" (同)unawares
- (primarily spatial sense) having little length or lacking in length; "short skirts"; "short hair"; "the board was a foot short"; "a short toss"
- at some point or distance before a goal is reached; "he fell short of our expectations"
- clean across; "the cars axle snapped short"
- not holding securities or commodities that one sells in expectation of a fall in prices; "a short sale"; "short in cotton"
- of speech sounds or syllables of relatively short duration; "the English vowel sounds in `pat, `pet, `pit, `pot, putt are short"
- primarily temporal sense; indicating or being or seeming to be limited in duration; "a short life"; "a short flight"; "a short holiday"; "a short story"; "only a few short months"
- so as to interrupt; "She took him up short before he could continue"
- tending to crumble or break into flakes due to a large amount of shortening; "shortbread is a short crumbly cookie"; "a short flaky pie crust"
- cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
- come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
- become attached by or as if by the process of growth; "The tree trunks had grown together"
- become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
- cause to grow or develop; "He grows vegetables in his backyard"
- increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
- (biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
- (pathology) an abnormal proliferation of tissue (as in a tumor)
- a progression from simpler to more complex forms; "the growth of culture"
- something grown or growing; "a growth of hair"
- vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
PrepTutorEJDIC
- (長さ・時間・距離などが)『短い』,近い・(人が)『背が低い』・(数量・期間などが)不足の』,乏しい;目標(標準)に達しない・(文などが)『簡潔な』,手短な・『そっけない』,ぞんぞいな,無愛想な・(ケーキなどが)かりかりする,さくさくする・(母音・音節が)短い;(詩の行の母音が)強勢のない・急に,突然・短いもの;欠けているもの・短篇映画(short movie, short subject) ・=short circuit・《複数形で》不足,欠損 / …‘を'短絡させる,ショートさせる / 短絡する,ショートする
- 『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
- 〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
- 《随伴・協調》…『と』,と共に,といっしょに / 《所有・所持》…『を持っている』,がある,の付いた / 《道具・手段》…『で』,を使って / 《財料・供給物》…『で』,を与えて / …を支持して,に賛成して / …『に反対(敵対)して』,を相手として / …『と同時に』,と同様に / …『に比べて』,に比例して / 《様態》《名詞を伴い副詞句として》『…で』,を示して,をもって / 《付帯状競》…『して』,しながら / 《譲歩》…がありながら,にもかかわらず / 『…が原因で』,のために,…で / …に任せて,のもとにあずけて,のところに / …に関して,について / …から離れて / 《連結・混合》…と / 《副詞と共に命令文で》
- 〈U〉〈C〉(…の)(量・額などの)不足,欠乏《+『of』(『in』)+『名』》 / 〈C〉不足分,不足量,不足額 / 〈C〉(精神・肉体などの)欠陥
UpToDate Contents
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English Journal
- Progressive Decline in Height Standard Deviation Scores in the First 5 Years of Life Distinguished Idiopathic Growth Hormone Deficiency from Familial Short Stature and Constitutional Delay of Growth.
- Rothermel J, Lass N, Toschke C, Reinehr T.
- Hormone research in paediatrics.Horm Res Paediatr.2016 Aug 12;86(2). [Epub ahead of print]
- BACKGROUND: Familial short stature (FSS) and constitutional delay of growth (CDG) are the most frequent norm variants in children presenting with short stature. Knowing the growth patterns of these entities in the first years of life might be helpful to distinguish them from growth hormone deficienc
- PMID 27513963
- A homozygous point mutation in the GH1 promoter (c.-223C>T) leads to reduced GH1 expression in siblings with isolated GH deficiency (IGHD).
- Madeira JL1, Jorge AA2, Martin RM1, Montenegro LR1, Franca MM1, Costalonga EF1, Correa FA1, Otto AP1, Arnhold IJ1, Freitas HS3, Machado UF3, Mendonca BB1, Carvalho LR4.
- European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2016 Aug;175(2):K7-K15. doi: 10.1530/EJE-15-0149. Epub 2016 Jun 1.
- CONTEXT: Mutations in the GH1 promoter are a rare cause of isolated growth hormone deficiency (IGHD).OBJECTIVE: To identify the molecular aetiology of a family with IGHD.DESIGN: DNA sequencing, electromobility shift (EMSA) and luciferase reporter assays.SETTING: University Hospital.PATIENTS: Three s
- PMID 27252485
- Reversible growth failure and complete GH deficiency in a 4-year-old girl with very early Hashimoto's thyroiditis and subsequent hyperplasia of pituitary thyrotroph cells.
- Gaspari L1,2,3, Paris F2,3, Leboucq N4, Bonafé A4, Sultan C5,6.
- European journal of pediatrics.Eur J Pediatr.2016 Aug;175(8):1119-22. doi: 10.1007/s00431-016-2698-6. Epub 2016 Feb 2.
- Hashimoto's thyroiditis is a well-known cause of growth retardation in adolescence. It is less frequently seen in children and rarely seen in infants. A 4-year-old girl was referred to our clinic for a second opinion before starting growth hormone (GH) treatment. Linear growth had markedly declined
- PMID 26838584
Japanese Journal
- Growth hormone deficiency in monozygotic twins with autosomal dominant pseudohypoparathyroidism type Ib
- Sano Shinichiro,Iwata Hiromi,Matsubara Keiko,Fukami Maki,Kagami Masayo,Ogata Tsutomu
- Endocrine Journal 62(6), 523-529, 2015
- … Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. …
- NAID 130005085768
- Growth hormone deficiency in monozygotic twins with autosomal dominant pseudohypoparathyroidism type Ib
- Sano Shinichiro,Iwata Hiromi,Matsubara Keiko,Fukami Maki,Kagami Masayo,Ogata Tsutomu
- Endocrine Journal advpub(0), 2015
- … Pseudohypoparathyroidism (PHP) is associated with compromised signal transductions via PTH receptor (PTH-R) and other G-protein-coupled receptors including GHRH-R. …
- NAID 130005060869
- Effect of Growth Hormone Treatment on Quality of Life in Japanese Children with Growth Hormone Deficiency: An Analysis from a Prospective Observational Study
- Tanaka Toshiaki,Hasegawa Tomonobu,Ozono Keiichi,Tanaka Hiroyuki,Kanzaki Susumu,Yokoya Susumu,Chihara Kazuo,Iwamoto Noriyuki,Seino Yoshiki
- Clinical Pediatric Endocrinology 23(3), 83-92, 2014
- … The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. … Children with GHD were treated with GH after enrollment. …
- NAID 130004677665
Related Links
- Individuals with normal variant short stature have an excellent prognosis. Treatment of patients with classic growth hormone deficiency (GHD) with rhGH can be expected to yield a height consistent with genetic potential ...
- 1. J Pediatr Endocrinol Metab. 2009 Oct;22(10):979-83. Short stature, celiac disease and growth hormone deficiency. Nemet D(1), Raz A, Zifman E, Morag H, Eliakim A. Author information: (1)Gastrointestinal ...
★リンクテーブル★
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- 英
- short stature with growth hormone deficiency, growth hormone deficient short statue
- 同
- 成長ホルモン分泌不全性低身長、(国試)(差別語)下垂体性小人症 pituitary dwarfism
- 関
- 低身長、成長ホルモン
病型
疫学
- 発症は乳児期以降。 ← 成長がGH dependentになるのは幼児期以降だから? まあ、新生児~乳児期に低GHによる他の症状は出現することがあるだろうけど。
病因
- 特発性:原因は不明であるが、出産時に骨盤分娩、仮死例が多い
症候
- 糖代謝:(重症例では?)新生児、乳幼児では低血糖、筋緊張低下。 ← 低成長ホルモンによる
- 全身:低身長(-2SD/-1.5SD(6歳以下))、低い身長の伸び(-1.5SD)
- 器質性の場合、原疾患による症状:頭蓋咽頭腫、胚芽腫など
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- 不足、欠乏、欠失、欠如、欠損、不十分。栄養不足、栄養素欠乏、欠乏症。(遺伝子)(染色体内の)遺伝子欠失
- 欠けているもの、不足している物。不足分。不完全なもの、欠点のあるもの
- 関
- absence, agenesis, dearth, defect, defective, deficient, deficit, delete, deletion, deletional, depletion, deprivation, deprive, lack, miss, missing, morphological defect, paucity, scarce, scarcity, starve
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- (比較級shorter-最上級shortest)短い、不足した、乏しい、省略された
- 関
- abbreviated、brevis、brief、dearth、deficit、in short、insufficiency、insufficient、lack、paucity、poor、scant、scanty、scarce、scarcity、shortage、shortness
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- (過去: grew-過去分詞: grown)
- 関
- extend、growth、outgrow、outgrowth、stretch
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