WordNet
- talk frankly with; lay it on the line; "I have to level with you"
- become level or even; "The ground levelled off" (同)level off
- indicator that establishes the horizontal when a bubble is centered in a tube of liquid (同)spirit_level
- height above ground; "the water reached ankle level"; "the pictures were at the same level"
- an abstract place usually conceived as having depth; "a good actor communicates on several levels"; "a simile has at least two layers of meaning"; "the mind functions on many strata simultaneously" (同)layer, stratum
- tear down so as to make flat with the ground; "The building was levelled" (同)raze, rase, dismantle, tear down, take_down, pull down
- not showing abrupt variations; "spoke in a level voice"; "she gave him a level look"- Louis Auchincloss (同)unwavering
- aim at; "level criticism or charges at somebody"
- being on a precise horizontal plane; "a billiard table must be level"
- oriented at right angles to the plumb; "the picture is level"
- make complete or perfect; supply what is wanting or form the complement to; "I need some pepper to complement the sweet touch in the soup"
- a complete number or quantity; "a full complement"
- one of a series of enzymes in the blood serum that are part of the immune response
- something added to complete or embellish or make perfect; "a fine wine is a perfect complement to the dinner"; "wild rice was served as an accompaniment to the main dish" (同)accompaniment
- number needed to make up a whole force; "a full complement of workers" (同)full complement
- a word or phrase used to complete a grammatical construction
- either of two parts that mutually complete each other
- an amber, watery fluid, rich in proteins, that separates out when blood coagulates (同)blood_serum
- the basic unit of money in Bulgaria
PrepTutorEJDIC
- (土地などが)『平らな』,水平な,凸凹のない / 『同じ高さ(程度)の』 / 《話》精神状態がよくつり合いのとれた,分別のある / 〈U〉〈C〉(地位・程度などの一般的な)『標準』,『水準』,レベル / 〈C〉(高さ・深さの基準となる)『水平面』,水平線 / 〈C〉〈U〉(ある物と比べたときの)『高さ』,深さ / 〈C〉(建物の)階,層 / 〈C〉《おもに米》(水準器《英》spirit level) / 〈物の表面〉‘を'『平らにする』 / 〈木・家など〉‘を'倒す / 〈地位・程度など〉‘を'一様にする,平均する / 《『level』+『名』+『at』+『名』》(目標に)〈銃など〉の水準器を合わせる / 《『level』+『名』+『at』(『against』)+『名』〈人〉》(人に)〈非難など〉‘を'浴びせる / 水平に,平らに
- (あるものを完全にするため)(…を)補う物(事)《+『of』+『名』》 / 補語(文法で文の成分の一つ) / (必要な)全数,全量;(船の)定員 / …を補足する,補う
- リンパ液 / 血清
- serial / series / sermon
UpToDate Contents
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- 1. 補体系の概要および臨床的評価 overview and clinical assessment of the complement system
- 2. 補体系の遺伝性疾患 inherited disorders of the complement system
- 3. 補体経路 complement pathways
- 4. 補体系の後天性疾患 acquired disorders of the complement system
- 5. 補体系の制御因子および受容体 regulators and receptors of the complement system
English Journal
- Effect of hypoxia on lung gene expression and proteomic profile: Insights into the pulmonary surfactant response.
- Olmeda B1, Umstead TM2, Silveyra P2, Pascual A3, López-Barneo J3, Phelps DS2, Floros J2, Pérez-Gil J4.Author information 1Dept. Bioquímica, Fac. Biología, Universidad Complutense, Madrid, Spain.2Center for Host Defense, Inflammation, and Lung Disease (CHILD), Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.3Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.4Dept. Bioquímica, Fac. Biología, Universidad Complutense, Madrid, Spain. Electronic address: jperezgil@bio.ucm.es.AbstractExposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic approach to describe the changes in protein complement induced by moderate long-term hypoxia (rats exposed to 10% O2 for 72h) in BAL and lung tissue, with a special focus on the proteins associated with pulmonary surfactant, which could indicate adaptation of this system to limited oxygen availability. The analysis of the general proteomic profile indicates a hypoxia-induced increase in proteins associated with inflammation both in lavage and lung tissue. Analysis at mRNA and protein levels revealed no significant changes induced by hypoxia on the content in surfactant proteins or their apparent oligomeric state. In contrast, we detected a hypoxia-induced significant increase in the expression and accumulation of hemoglobin in lung tissue, at both mRNA and protein levels, as well as an accumulation of hemoglobin both in BAL and associated with surface-active membranes of the pulmonary surfactant complex. Evaluation of pulmonary surfactant surface activity from hypoxic rats showed no alterations in its spreading ability, ruling out inhibition by increased levels of serum or inflammatory proteins.
- Journal of proteomics.J Proteomics.2014 Apr 14;101:179-91. doi: 10.1016/j.jprot.2014.02.019. Epub 2014 Feb 24.
- Exposure of lung to hypoxia has been previously reported to be associated with significant alterations in the protein content of bronchoalveolar lavage (BAL) and lung tissue. In the present work we have used a proteomic approach to describe the changes in protein complement induced by moderate long-
- PMID 24576641
- Mannan-binding lectin serum levels in 593 healthy Iranian children and adults.
- Zahedifard S1, Rashidi E, Shams S, Saghafi S, Fazlollahi M, Talebzadeh A, Kazemnejad A, Soltani A, Pourpak Z.Author information 1Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. sara_zfm@yahoo.com.AbstractMannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization. MBL deficiency has been classified as the most common inherited immunodeficiency known in humans (about 30% of the population), and is associated with predisposition to infections and high risk of some autoimmune diseases. The purpose of this study was to determine the profile of MBL serum level in Iranian healthy population in association with sex and age groups for the first time. We studied the serum concentration of MBL in 593 Iranian healthy cases: 340 males and 235 females in 4 different age groups by using enzyme-linked immunosorbent assay. The mean serum levels of MBL were 3.854± 2.77µg/ml at the age of less than 6 months, 4.147±3.54µg/ml at 6 months to 2 years of age, 4.410±3.09µg/ml at 2-6 years and 2.207±1.73µg/ml in adults. There was significant differences in the mean concentration of MBL among different age groups of children and also between children and adults (p<0.05). No association was observed between sex and MBL concentrations. MBL serum levels of Iranian population seem to be different from some of other populations which may be explained by genetic variations. The MBL values in this study can be used as a normal reference range for future studies in Iranian population.
- Iranian journal of allergy, asthma, and immunology.Iran J Allergy Asthma Immunol.2014 Apr;13(2):120-4.
- Mannan-binding lectin (MBL) is a vital protein of innate immune system and has two critical functions: complement activation through the lectin pathway and opsonization. MBL deficiency has been classified as the most common inherited immunodeficiency known in humans (about 30% of the population), an
- PMID 24338257
- An ELISA assay with two monoclonal antibodies allows the estimation of free factor H and identifies patients with acquired deficiency of this complement regulator.
- Nozal P1, Garrido S1, Alba-Domínguez M2, Espinosa L3, Peña A3, Córdoba SR4, Sánchez-Corral P5, López-Trascasa M6.Author information 1Unidad de Inmunología, IdiPAZ, Hospital Universitario La Paz, Madrid 28046, Spain; Centro de Investigación Biomédica en Red (CIBERER U754), Madrid, Spain.2Unidad de Inmunología, IdiPAZ, Hospital Universitario La Paz, Madrid 28046, Spain.3Servicio de Nefrología Pediátrica, Hospital Universitario La Paz, Madrid 28046, Spain.4Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CIB-CSIC), Centro de Investigación Médica en Red (CIBERER U738), Madrid 28040, Spain.5Unidad de Investigación, IdiPAZ, Hospital Universitario La Paz, Madrid 28046, Spain; Centro de Investigación Biomédica en Red (CIBERER U754), Madrid, Spain.6Unidad de Inmunología, IdiPAZ, Hospital Universitario La Paz, Madrid 28046, Spain; Centro de Investigación Biomédica en Red (CIBERER U754), Madrid, Spain. Electronic address: mltrascasa@salud.madrid.org.AbstractComplement factor H (FH) serum levels can be affected by the presence of immune complexes of FH with autoantibodies like in autoimmune forms of atypical haemolytic uraemic syndrome (aHUS) or with C3b in homozygous factor I (FI) deficiency. These complexes reduce the amount of free functional circulating FH. In this study we aimed to determine whether FH levels measurement is disturbed in some pathological conditions and to establish a method for quantifying free and total FH in serum. For that purpose, FH levels were measured in serum samples from aHUS patients having anti-FH autoantibodies or mutations in FH gene, in patients with homozygous FI deficiency, and in healthy controls. Two anti-FH monoclonal antibodies, OX24 and A229, recognizing different functional regions in FH, were used as capture antibodies in an ELISA assay. In the control group and in the group of patients with FH mutations, the FH levels obtained with the two monoclonal antibodies were similar. In patients with anti-FH autoantibodies or with homozygous FI deficiency, however, FH levels measured with both antibodies were significantly different. As these patients had complexes of FH with autoantibodies or C3b, we interpreted that OX24 was detecting total FH and A229 was recognising free FH. Therefore, quantification of FH in plasma using these two monoclonal antibodies provides not only total FH level but also gives an estimation of how much FH circulates free and is thus available to properly control complement activation.
- Molecular immunology.Mol Immunol.2014 Apr;58(2):194-200. doi: 10.1016/j.molimm.2013.11.021. Epub 2013 Dec 28.
- Complement factor H (FH) serum levels can be affected by the presence of immune complexes of FH with autoantibodies like in autoimmune forms of atypical haemolytic uraemic syndrome (aHUS) or with C3b in homozygous factor I (FI) deficiency. These complexes reduce the amount of free functional circula
- PMID 24378252
Japanese Journal
- 血行再建術後の感染増悪により大切断に至った CLI 症例の患者因子の検討:～特に周術期CRP値の重要性について～
- 西尾 祐美,榊原 俊介,寺師 浩人,橋川 和信,田原 真也
- 創傷 5(4), 189-193, 2014
- 重症下肢虚血 ( critical limb ischemia : CLI ) 症例で，始めは下肢小切断術を計画していても血行再建術後の感染増悪により，結果的に下肢大切断術に至る場合がある。2005 年～ 2009 年までの 5 年間に経験したCLI症例 13 例のうち 3 例が大切断術となった。大切断術に至った症例と小切断術で治癒した症例について，患者因子を基に比較検討を行った。年齢，糖尿病の …
- NAID 130004697035
- 抗CFH 抗体陽性およびCFHR1 遺伝子欠失を伴うDEAP-HUS の1 例
- 岡 政史,大塚 泰史,稲田 由紀子,佐藤 忠司,吉田 瑶子,藤村 吉博, ,宮田 敏行,濱崎 雄平
- 日本小児腎臓病学会雑誌 26(2), 285-291, 2014
- 近年，病原性大腸菌および肺炎球菌感染を伴わない非典型溶血性尿毒症症候群（atypical hemolytic uremic syndrome; aHUS）の半数以上は補体制御因子の障害が原因であると報告され，その病因の違いによる治療反応性や予後に関心が集まっている。我々はHUS の4 歳男児を経験した。児は嘔吐と水様便を伴って発症したものの，軽度の低補体血症がありベロ毒素および病原性大腸菌は検出さ …
- NAID 130004495423
- 腎細胞癌と鑑別が困難であったIgG4関連腎臓病の1例
- 野藤 誓亮,進藤 哲哉,水野 孝祐 [他],田中 俊明,北村 寛,高橋 聡,舛森 直哉,塚本 泰司
- 泌尿器科紀要 = Acta urologica Japonica 59(8), 513-515, 2013-08
- … Additionally, the serum IgG4 level was elevated postoperatively and the patient was diagnosed as having IgG4-related kidney disease. … Measuring the serum immunoglobulin and complement levels may be helpful for avoiding unnecessary surgery. …
- NAID 120005322756
Related Links
- How to Cite Yoshikawa, S., Yamada, K. and Yoshida, T. O. (1969), Serum complement level in patients with leukemia. Int. J. Cancer, 4: 845–851. doi: 10.1002/ijc ... The serum complement level was studied in 94 cases of patients ...
- The serum complement level was determined in 79 persons subject to occupational exposure to benzene, toluene and xylene. In 62 of them the complement level was lower than the mean value of the control
Related Pictures
★リンクテーブル★
| リンク元 | 「補体価」「血清補体値」 |
| 関連記事 | 「complement」「level」 |
「補体価」
- 英
- complement activity, complement titer
- 同
- 血清補体価 serum complement level, serum complement titer
- 関
- CH50
概念
- 抗体に感作されたヒツジ抗体を50%溶血を生じさせる血清量。
- 補体活性の指標となる；古典経路と共通経路の評価。
正常値
- 70-110 CH50
補体価が変化する病態 (OLM.394)
高値
- 炎症疾患
低値
- (1)産生低下による病態
- 1. 後天性産生低下
- 重症肝障害(肝硬変、劇症肝炎、慢性肝炎)
- 2. 先天性産生低下
- (2)補体活性が亢進する病態
- 1. 古典経路が活性化される病態
- 2. 代替経路が亢進する病態
← 補体価では代替経路は評価していない ← どういうこと？
- (3)補体成分の異化が亢進する病態
- 蛋白質漏出性病態(肝機能が保たれていれば、補償される)
- (4)cold activation
- 生体外で肝や血清を放置すると古典経路が活性化される状態で、血清抗体価は減少するが補体成分タンパク量は減少しない。EDTAを抗凝固剤として用いるとこの現象はみられない。 ← ？
- 慢性C型肝炎、肝硬変、混合型クリオグロブリン血症
血清補体価の低下
- 血清補体価の低下が疾患の高活動性
国試
「血清補体値」
「complement」
- n.
- 補って完全にする物、補完物。(免疫)補体
- (必要な)全数、善良
- vt.
- 補って完全にする。補完する。～の補足となる。
「level」