新生児発作

WordNet

a sudden occurrence (or recurrence) of a disease; "he suffered an epileptic seizure" (同)ictus, raptus
the taking possession of something by legal process
relating to or affecting the infant during the first month after birth; "neonatal care"; "the neonatal period"

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〈U〉〈C〉つかむ(つかまれる)こと / 〈U〉〈C〉強奪;差し押さえ;逮捕 / 〈C〉(病気・恐怖などが)襲うこと,発作
新生児の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/07/08 15:52:23」(JST)

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Seizures in neonates (newborns) remain the most frequent neurological problem in the nursery. Considerable debate about their consequences exists between data and deductions reached through animal experimentations and those obtained through clinical investigations. The main conflicting issues are whether seizures in newborns can plant the roots for epileptogenesis and cause long-term deficits.^[1]

Most neonatal seizures occur over a short time, usually only for a few days. Fewer than half of the affected infants develop seizures in later life. Such neonatal seizures are considered acute reactive (acute symptomatic), and thus the term neonatal epilepsy is not used to describe these seizures. The incidence of neonatal seizures has not been clearly established, although an estimated frequency of 80-120 cases per 100,000 neonates per year has been suggested. The incidence of seizures is higher in the neonatal period (i.e., the first 4 wk after birth) than at any other time of life ^[2]

Classification

Clonic seizures

These movements most commonly are associated with electrographic seizures. They often involve 1 extremity or 1 side of the body. The rhythm of the clonic movements is usually slow, at 1-3 movements per second.

Tonic seizures

These may involve 1 extremity or the whole body. Focal tonic seizures involving 1 extremity often are associated with electrographic seizures.

Generalized tonic seizures often manifest with tonic extension of the upper and lower limbs and also may involve the axial musculature in an opisthotonic fashion. Generalized tonic seizures mimic decorticate posturing; the majority are not associated with electrographic seizures.

Myoclonic seizures

These may occur focally in 1 extremity or in several body parts (in which case they are described as multifocal myoclonic seizures).

Focal and multifocal myoclonic seizures typically are not associated with electrographic correlates. Generalized myoclonic jerks are possibly the clinical equivalent of infantile spasms.

References

^ http://reference.medscape.com/medline/abstract/17571356
^ http://reference.medscape.com/medline/abstract/10685200

UpToDate Contents

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1. 新生児痙攣の病因および予後 etiology and prognosis of neonatal seizures
2. 新生児痙攣の治療 treatment of neonatal seizures
3. 新生児痙攣の臨床的特徴および電気診断 clinical features and electrodiagnosis of neonatal seizures
4. 新生児てんかん症候群 neonatal epileptic syndromes
5. 新生児脳症の臨床的特徴、診断、および治療 clinical features diagnosis and treatment of neonatal encephalopathy

English Journal

Neonatal status epilepticus: Differences between preterm and term newborns.

Pavlidis E1, Spagnoli C2, Pelosi A3, Mazzotta S2, Pisani F2.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.Eur J Paediatr Neurol.2015 May;19(3):314-9. doi: 10.1016/j.ejpn.2015.01.002. Epub 2015 Jan 10.
BACKGROUND: Despite the many studies on neonatal seizures, neonatal status epilepticus (NSE) remains a controversial entity, with no general consensus about its definition. We report the characteristics of newborns with NSE in order to assess whether they showed homogeneous features or displayed cli
PMID 25613545

De Novo Mutations in SIK1 Cause a Spectrum of Developmental Epilepsies.

Hansen J1, Snow C2, Tuttle E1, Ghoneim DH1, Yang CS2, Spencer A2, Gunter SA3, Smyser CD4, Gurnett CA4, Shinawi M5, Dobyns WB6, Wheless J7, Halterman MW8, Jansen LA3, Paschal BM9, Paciorkowski AR10.
American journal of human genetics.Am J Hum Genet.2015 Apr 2;96(4):682-90. doi: 10.1016/j.ajhg.2015.02.013.
Developmental epilepsies are age-dependent seizure disorders for which genetic causes have been increasingly identified. Here we report six unrelated individuals with mutations in salt-inducible kinase 1 (SIK1) in a series of 101 persons with early myoclonic encephalopathy, Ohtahara syndrome, and in
PMID 25839329

How to use: amplitude-integrated EEG (aEEG).

Shah NA1, Wusthoff CJ1.
Archives of disease in childhood. Education and practice edition.Arch Dis Child Educ Pract Ed.2015 Apr;100(2):75-81. doi: 10.1136/archdischild-2013-305676. Epub 2014 Jul 17.
Amplitude-integrated electroencephalography (aEEG) is a method for continuous monitoring of brain activity that is increasingly used in the neonatal intensive care unit. In its simplest form, aEEG is a processed single-channel electroencephalogram that is filtered and time-compressed. Current eviden
PMID 25035312

Japanese Journal

Neonatal status epilepticus due to lamination disorder without significant cell death

ANSART-FRANQUET Helene,DEVISME Louise,MAURAGE Claude-Alain,LAMBLIN Marie-Dominique,SOTO-ARES Gustavo,RENARD-EDUN Marie-Eve,KACET Nadine,GRESSENS Pierre,AUVIN Stephane
Brain & development 33(4), 339-344, 2011-04-01
NAID 10029561415

Pyridoxine-dependent status epilepticus diagnosed during infancy

Imataka George,Kuribayashi Ryouta,Tsukada Keiko,Tsuboi Tatsuo,Yamanouchi Hideo,Arisaka Osamu
Epilepsy & Seizure
… The disorder develops mainly during the early neonatal period, and cases diagnosed in infants are even rarer. …
NAID 130000761120