adj.

御しにくい、手に負えない、強情な。処置\加工しにくい。(病気などが)治りにくい、難治の/難治性の。

plasmapheresis has been utilized rarely in patients with severe intractable pruritus.

Ongoing diuretic resistance with intractable edema and hypertension in advanced CKD may serve as an indication to initiate dialysis.(HIM.1764)

関: arduous、difficult、difficulty、distress、hard、inveterate、labored、recalcitrant、refractory、trouble

WordNet

not tractable; difficult to manage or mold; "an intractable disposition"; "intractable pain"; "the most intractable issue of our era"; "intractable metal"
an intense itching sensation that can have various causes (as by allergies or infection or lymphoma or jaundice etc.)
plasma is separated from whole blood and the rest is returned to the donor
with pain or distress or bitterness; "he took the rejection very hard"
(of light) transmitted directly from a pointed light source (同)concentrated
with firmness; "held hard to the railing" (同)firmly
very strong or vigorous; "strong winds"; "a hard left to the chin"; "a knockout punch"; "a severe blow" (同)knockout, severe
causing great damage or hardship; "industries hit hard by the depression"; "she was severely affected by the banks failure" (同)severely
being distilled rather than fermented; having a high alcoholic content; "hard liquor" (同)strong
unfortunate or hard to bear; "had hard luck"; "a tough break" (同)tough
(of speech sounds); produced with the back of the tongue raised toward or touching the velum; "Russian distinguished between hard consonants and palatalized or soft consonants"
dispassionate; "took a hard look"; "a hard bargainer";
dried out; "hard dry rolls left over from the day before"
earnestly or intently; "thought hard about it"; "stared hard at the accused"
into a solid condition; "concrete that sets hard within a few hours"
resisting weight or pressure
slowly and with difficulty; "prejudices die hard"
to the full extent possible; all the way; "hard alee"; "the ship went hard astern"; "swung the wheel hard left"
very near or close in space or time; "it stands hard by the railroad tracks"; "they were hard on his heels"; "a strike followed hard upon the plants opening"
with effort or force or vigor; "the team played hard"; "worked hard all day"; "pressed hard on the lever"; "hit the ball hard"; "slammed the door hard"
to cause inconvenience or discomfort to; "Sorry to trouble you, but..." (同)put_out, inconvenience, disoblige, discommode, incommode, bother
cause bodily suffering to and make sick or indisposed (同)ail, pain
an unwanted pregnancy; "he got several girls in trouble"
an effort that is inconvenient; "I went to a lot of trouble"; "he won without any trouble"; "had difficulty walking"; "finished the test only with great difficulty" (同)difficulty
a source of difficulty; "one trouble after another delayed the job"; "whats the problem?" (同)problem
an event causing distress or pain; "what is the trouble?"; "heart trouble"
a condition or state of affairs almost beyond ones ability to deal with and requiring great effort to bear or overcome; "grappling with financial difficulties"
the quality of being difficult; "they agreed about the difficulty of the climb" (同)difficultness
a factor causing trouble in achieving a positive result or tending to produce a negative result; "serious difficulties were encountered in obtaining a pure reagent"
difficult to accomplish; demanding considerable mental effort and skill; "the arduous work of preparing a dictionary"
characterized by effort to the point of exhaustion; especially physical effort; "worked their arduous way up the mining valley"; "a grueling campaign"; "hard labor"; "heavy work"; "heavy going"; "spent many laborious hours on the project"; "set a punishing pace" (同)backbreaking, grueling, gruelling, hard, heavy, laborious, operose, punishing, toilsome
taxing to the utmost; testing powers of endurance; "his final, straining burst of speed"; "a strenuous task"; "your willingness after these six arduous days to remain here"- F.D.Roosevelt (同)straining, strenuous
temporarily unresponsive or not fully responsive to nervous or sexual stimuli; "the refractory period of a muscle fiber"
not responding to treatment; "a stubborn infection"; "a refractory case of acne"; "stubborn rust stains" (同)stubborn

PrepTutorEJDIC

(人・人の性質が)手に負えない,強情な / (物事が)処理しにくい,取り扱いにくい
(物体が)『堅い』,(手触りが)堅固な,しっかりした / 『難しい』,努力を要する / 《名詞の前にのみ用いて》(人が)『精力的な』,勤勉な / 激しい,猛烈な / (生活などが)耐え難い,つらい / (季節・天候などが)厳しい;(雨・風などが)激しい / (人が)厳格な;(行為などが)容赦しない,無情な / (方針・条件などが)妥協(譲歩)しない,厳しい / (感情が)うらみを含む,憤然とした / (体が)筋肉質の,がんじょうな / (紙幣に対して)硬貨の,(小切手などに対して)現金の;(貨幣が)容易に兌換(だかん)できる / (子音が)硬音の(c,gがcome, goのように[k],[g]と発音される) / アルコール分の多い / (水が)硬質の / (エックス線が)透過能力が大きい / 一生懸命に,『熱心に』 / 『強く』,激しく,大いに / やっと,かろうじて / 『堅く』 / ひどく悲んで / 接近して
〈U〉『苦難』,心配,悩み / 〈C〉『苦労の種』,心配事,悩みの種 / 〈U〉危険[な状態],困難 / 〈U〉『骨折り』,手数,めんどう,迷惑 / 〈C〉〈U〉(政治的・社会的)紛争,騒動 / 〈U〉(機械などの)故障 / 〈C〉〈U〉病気 / 〈事が〉〈人・自分〉‘を'『悩ます』,心配させる,苦しめる / 《物事を頼むときていねいに》〈人〉‘を'『わずらわす』,じゃまする / 〈水・空気など〉‘を'かき乱す / 《おもに疑問文・否定文で》心配する,気を遣う;骨を折る
〈U〉『難しさ』,困難 / 〈C〉『困難なこと』,難事,障害 / 〈C〉《通例複数形で》『困難な状況』,(特に)財政困難 / 〈C〉〈U〉(…との)不和,仲たがい《+『with』(『between』)+『名』》 / 〈C〉苦情,反対
骨の折れる,困難な / (山などが)登りにくい,けわしくて骨の折れる / (努力などが)しんぼう強い,奮闘する(strenuous)
(人などが)手に負えない,強情な / (病気が)治りにくい,がんこな / (金属などが)溶けにくい,耐火性の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/28 21:52:22」(JST)

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English Journal

Review structure- and dynamics-based computational design of anticancer drugs.

Lin JH1,2,3.
Biopolymers.Biopolymers.2016 Jan;105(1):2-9. doi: 10.1002/bip.22744.
Cancer is a class of highly complex diseases involving multiple genes and multiple cross-talks between signaling networks. Cancer cells may be developed from inherited defects or acquired damages of DNA. However, many cancers are resistant to treatment, and metastasis of cancers makes the disease ev
PMID 26385494
PMID 26220405

The influence of headaches in patients with chronic dizziness.

Goto F1, Arai M1, Arai M2.
Acta oto-laryngologica.Acta Otolaryngol.2015 Dec;135(12):1264-7. doi: 10.3109/00016489.2015.1076171. Epub 2015 Aug 27.
CONCLUSION: The frequency of headaches in patients complaining of chronic dizziness is closely related to the severity of the dizziness impairments and mood states, such as anxiety. It is, therefore, important to treat co-morbid headache in patients with chronic dizziness. The severity of the dizzin
PMID 26313013

Clinical outcomes of tracheoesophageal diversion and laryngotracheal separation for aspiration in patients with severe motor and intellectual disability.

Takano K1, Kurose M1, Mitsuzawa H2, Nagaya T1,2, Himi T1.
Acta oto-laryngologica.Acta Otolaryngol.2015 Dec;135(12):1304-10. doi: 10.3109/00016489.2015.1067905. Epub 2015 Jul 25.
CONCLUSIONS: Tracheoesophageal diversion (TED) and laryngotracheal separation (LTS) can prevent aspiration pneumonia and improve the morbidity of patients with severe motor and intellectual disability (SMID). By improving hospitalization rates and care needs, the quality-of-life can be improved for
PMID 26211394