WordNet

suffer or be susceptible to damage; "These fine china cups damage easily"
inflict damage upon; "The snow damaged the roof"; "She damaged the car when she hit the tree"
the act of damaging something or someone (同)harm, hurt, scathe
loss of military equipment (同)equipment casualty
the occurrence of a change for the worse (同)harm, impairment
spread out; not concentrated in one place; "a large diffuse organization"
move outward; "The soldiers fanned out" (同)spread, spread out, fan out
lacking conciseness; "a diffuse historical novel"
pertaining to the tiny air sacs of the lungs
pertaining to the sockets of the teeth or that part of the upper jaw; "alveolar processes"
designed or tending to discredit, especially without positive or helpful suggestions; "negative criticism" (同)negative
(sometimes followed by `to' (同)detrimental, prejudicial, prejudicious
harmed or injured or spoiled; "I wont buy damaged goods"; "the storm left a wake of badly damaged buildings"

PrepTutorEJDIC

〈U〉『損害』,損傷,被害 / 《複数形で》損害賠障[金] / 《the~》《単数形で》《話》飛用 / …‘に'損傷する
〈光・熱・液体など〉‘を'散らす,放散する,拡散させる / 〈学問・知識など〉‘を'広める,普及させる / 散る,放散する,拡散する / 広まる,普及する / 広く散った,広がった / 〈文体などが〉締まりのない,散漫な
歯茎音の(舌先を上歯茎にふれて発音する) / 肺胞の;歯槽(しそう)の / 歯茎音

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/03/10 03:20:01」(JST)

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Micrograph showing hyaline membranes, the key histologic feature of diffuse alveolar damage. H&E stain.

Diffuse alveolar damage is a histological pattern in lung disease. It is seen in acute respiratory distress syndrome (ARDS),^[1] transfusion related acute lung injury (TRALI) and acute interstitial pneumonia (AIP).

§Prevalence

It is a common biopsy finding.^[2] Through histology, diffuse alveolar damage goes through several stages:

Exudative phase - similar to pulmonary edema. The alveoli become flooded with transudate
Hyaline membrane production. Hyaline membranes are fibrous structures laid down in order to stop oxygen being absorbed via the damaged alveoli.
Organising phase

§Etiology

Diffuse alveolar damage is associated primarily with ARDS and TRALI in adults, and hyaline membrane disease in neonates. It is most commonly associated with infection.^[3]

§References

^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 715. ISBN 0-7216-0187-1.
^ Parambil JG, Myers JL, Ryu JH (August 2006). "Diffuse alveolar damage: uncommon manifestation of pulmonary involvement in patients with connective tissue diseases". Chest 130 (2): 553–8. doi:10.1378/chest.130.2.553. PMID 16899858.
^ Parambil JG, Myers JL, Aubry MC, Ryu JH (July 2007). "Causes and prognosis of diffuse alveolar damage diagnosed on surgical lung biopsy". Chest 132 (1): 50–7. doi:10.1378/chest.07-0104. PMID 17475632.

§External links

Gross pathology of DAD - utah.edu.
Microscopic pathology of DAD - utah.edu.

This article about a medical condition affecting the respiratory system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. びまん性肺胞出血症候群 the diffuse alveolar hemorrhage syndromes
2. 急性間質性肺炎（ハマンリッチ症候群） acute interstitial pneumonia hamman rich syndrome
3. 間質性肺疾患における肺生検結果の解釈 interpretation of lung biopsy results in interstitial lung disease
4. 急性呼吸窮迫症候群：成人における臨床的特徴および診断 acute respiratory distress syndrome clinical features and diagnosis in adults
5. 急性呼吸窮迫症候群：成人における疫学、病態生理、病理、および病因 acute respiratory distress syndrome epidemiology pathophysiology pathology and etiology in adults

English Journal

The effect of octreotide, an analog of somatostatin, on bleomycin-induced interstitial pulmonary fibrosis in rats.

Tug T, Kara H, Karaoglu A, Karatas F, Turgut NH, Ayan E, Boran C, Tug E.SourceDepartment of Chest Diseases, Faculty of Medicine, Abant Izzet Baysal University , Bolu , Turkey.
Drug and chemical toxicology.Drug Chem Toxicol.2013 Apr;39(2):181-6. doi: 10.3109/01480545.2012.710618. Epub 2012 Sep 5.
In this study, octreotide (OCT), a synthetic somatostatin analog, was tested for its beneficial effects in the prevention of interstitial pulmonary fibrosis (IPF) induced by bleomycin (BLM) in rats by histological examination and by evaluating tissue OH-proline levels. Thirty male Wistar rats were d
PMID 22946449

A case of interstitial lung disease associated with clinically amyopathic dermatomyositis: radiologic-pathologic correlation.

Okubo G, Noma S, Nishimoto Y, Sada R, Kobashi Y.SourceDepartments of *Radiology †General Internal Medicine ‡Pathology, Tenri Hospital, Nara, Japan.
Journal of thoracic imaging.J Thorac Imaging.2013 Jan;28(1):W24-6. doi: 10.1097/RTI.0b013e31826af2b7.
This case report describes a 64-year-old woman with interstitial lung disease associated with clinically amyopathic dermatomyositis. Chest computed tomography revealed consolidations along bronchovascular bundles in the periphery of the lower lungs. Interstitial lung disease developed acutely, and t
PMID 23047733

Japanese Journal

Epithelial regeneration after diffuse alveolar damage in relation to underlying disease and DAD stage: an autopsy study

Asano Satoru,Takemura Tamiko,Katoh Keiichi,Taneda Masuzoh,Kitagawa Masanobu
Journal of medical and dental sciences 58(4), 113-121, 2011-12
NAID 110008716097

Pathology: Diffuse alveolar damage in a young cat

Kobayashi Ryosuke,Yamano Shigeki,Tanaka Katsuyuki [他]
日本獣醫學会会誌 73(10), 1347-1349, 2011-10
NAID 40019050688

薬剤性肺障害の病理形態学

岡輝明
呼吸器内科 20(2), 163-168, 2011-08
NAID 40019010684

Related Pictures

★リンクテーブル★

リンク元	「急性間質性肺炎」「びまん性肺胞障害」「DAD」
関連記事	「damage」「diffuse」「alveolar」「damaged」

「急性間質性肺炎」

　　[★]

英: acute interstitial pneumonitis acute interstitial pneumonia AIP
関: 特発性間質性肺炎、diffuse alveolar damage DAD; ハンマン-リッチ症候群

特徴

臨床診断名	AIP
病理組織像	DAD
分布	びまん性,均質
時相	均質
間質への細胞浸潤	少ない
胞隔の炎症	なし
線維芽細胞巣	びまん性,間質
肺胞内マクロファージ集積	なし
肺胞腔内線維化	しばしば
顕微鏡的蜂巣肺(肺胞虚説)	なし
硝子膜	高頻度