同: 黒色病変

WordNet

of or belonging to a racial group having dark skin especially of sub-Saharan African origin; "a great people--a black people--...injected new meaning and dignity into the veins of civilization"- Martin Luther King Jr.
the quality or state of the achromatic color of least lightness (bearing the least resemblance to white) (同)blackness, inkiness
(board games) the darker pieces
black clothing (worn as a sign of mourning); "the widow wore black"
(of the face) made black especially as with suffused blood; "a face black with fury" (同)blackened
offering little or no hope; "the future looked black"; "prospects were bleak"; "Life in the Aran Islands has always been bleak and difficult"- J.M.Synge; "took a dim view of things" (同)bleak, dim
(of events) having extremely unfortunate or dire consequences; bringing ruin; "the stock market crashed on Black Friday"; "a calamitous defeat"; "the battle was a disastrous end to a disastrous campaign"; "such doctrines, if true, would be absolutely fatal to my theory"- Charles Darwin; "it is fatal to enter any war without the will to win it"- Douglas MacArthur; "a fateful error" (同)calamitous, disastrous, fatal, fateful
stemming from evil characteristics or forces; wicked or dishonorable; "black deeds"; "a black lie"; "his black heart has concocted yet another black deed"; "Darth Vader of the dark side"; "a dark purpose"; "dark undercurrents of ethnic hostility"; "the scheme of some sinister intelligence bent on punishing him"-Thomas Hardy (同)dark, sinister
(used of conduct or character) deserving or bringing disgrace or shame; "Man...has written one of his blackest records as a destroyer on the oceanic islands"- Rachel Carson; "an ignominious retreat"; "inglorious defeat"; "an opprobrious monument to human greed"; "a shameful display of cowardice" (同)disgraceful, ignominious, inglorious, opprobrious, shameful
harshly ironic or sinister; "black humor"; "a grim joke"; "grim laughter"; "fun ranging from slapstick clowning ... to savage mordant wit" (同)grim, mordant
extremely dark; "a black moonless night"; "through the pitch-black woods"; "it was pitch-dark in the cellar" (同)pitch-black, pitch-dark
soiled with dirt or soot; "with feet black from playing outdoors"; "his shirt was black within an hour" (同)smutty
(of coffee) without cream or sugar
(of intelligence operations) deliberately misleading; "black propaganda"
being of the achromatic color of maximum darkness; having little or no hue owing to absorption of almost all incident light; "black leather jackets"; "as black as coal"; "rich black soil"
marked by anger or resentment or hostility; "black looks"; "black words"
any localized abnormal structural change in a bodily part
a person with dark skin who comes from Africa (or whose ancestors came from Africa) (同)Black person, blackamoor, Negro, Negroid
British chemist who identified carbon dioxide and who formulated the concepts of specific heat and latent heat (1728-1799) (同)Joseph Black
popular child actress of the 1930s (born in 1928) (同)Shirley Temple Black, Shirley Temple

PrepTutorEJDIC

『黒い』,黒色の / 『暗い』,まっ暗な(dark) / (特にアフリカ系)黒人の / 汚い(dirty),汚れた(soiled) / 陰気な(gloomy);不吉な;見通しの暗い / 怒った(angry);不きげんな(sullen) / 腹黒い,邪悪な(wicked, evil) / 《文》不名誉な / (コーヒーに)クリーム(牛乳)を入れない,ブラックの / 〈U〉『黒』,『黒色』 / 〈C〉《しばしば『B-』》黒人 / 〈U〉黒衣,(特に)喪服 / 黒くなる;暗くなる / …'を'黒くする;…'を'暗くする(blacken) / (靴墨で)〈靴〉'を'みがく
傷害,傷 / (体の組織や機能の)障害
黒くするもの,(特に)靴墨

UpToDate Contents

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1. 成人における多発性硬化症の診断 diagnosis of multiple sclerosis in adults
2. 口腔病変 oral lesions
3. 小児における中枢神経系の急性脱髄の鑑別診断 differential diagnosis of acute central nervous system demyelination in children
4. その他の紅斑熱群リケッチア感染 other spotted fever group rickettsial infections
5. ゴケグモによる咬刺傷の臨床症状および診断 clinical manifestations and diagnosis of widow spider bites

English Journal

Clinical significance of ureteric 'skip lesions' at the time of radical cystectomy: the M.D. Anderson experience and literature review.

Hoang AN1, Agarwal PK, Walton-Diaz A, Wood CG, Metwalli AR, Kassouf W, Brown GA, Black PC, Urbauer DL, Grossman HB, Dinney CP, Kamat AM.Author information 1Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.AbstractOBJECTIVE: To assess the incidence and clinical significance of 'skip lesions' that are present in proximal but not in distal ureteric sections, which are occasionally found during the pathological examination of ureteric margins during radical cystectomy (RC).
BJU international.BJU Int.2014 May;113(5b):E28-33. doi: 10.1111/bju.12344.
OBJECTIVE: To assess the incidence and clinical significance of 'skip lesions' that are present in proximal but not in distal ureteric sections, which are occasionally found during the pathological examination of ureteric margins during radical cystectomy (RC).PATIENTS AND METHODS: We identified 660
PMID 24053608

Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study.

Giannetti P1, Politis M2, Su P3, Turkheimer F4, Malik O5, Keihaninejad S6, Wu K7, Reynolds R8, Nicholas R9, Piccini P10.Author information 1Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: p.giannetti@imperial.ac.uk.2Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK; Neurodegeneration Imaging Group, Department of Clinical Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: marios.politis@imperial.ac.uk.3Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: paul.su08@imperial.ac.uk.4Centre for Neuroimaging, Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. Electronic address: federico.turkheimer@kcl.ac.uk.5Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: Omar.Malik@imperial.nhs.uk.6Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: s.keihaninejad@ucl.ac.uk.7Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: kit.wu@imperial.ac.uk.8Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: r.reynolds@imperial.ac.uk.9Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: richard.nicholas@imperial.nhs.uk.10Centre for Neuroinflammation and Neurodegeneration, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK. Electronic address: paola.piccini@imperial.ac.uk.AbstractThe pathophysiological correlates and the contribution to persisting disability of hypointense T1-weighted MRI lesions, black holes (BH), in multiple sclerosis (MS) are still unclear. In order to study the in vivo functional correlates of this MRI finding, we used 11C-PK11195 PET (PK-PET) to investigate changes in microglial activity. Ten relapsing and 9 progressive MS subjects had a PK-PET scan and a MRI scan alongside a full clinical assessment, including the expanded disability status scale (EDSS) for evaluation of disability. We studied the PK binding potential of the specifically bound radioligand relative to the non-displaceable radioligand in tissue (BPND) in T1 BHs. Out of a total of 1242 BHs identified, 947 were PK enhancing. The PKBPND was correlated with the EDSS (r=0.818; p<0.05) only in the progressive group. In the relapsing patients there was an inverse correlation between PKBPND and BH total lesion volume in whole brain (r=-0.781; p<0.05). When progressive patients were grouped according to the disability outcome at 2years from the PK-PET scan, the total PKBPND in BHs was found to be a significant outcome predictor of disability (p<0.01). Our findings show that relapsing and progressive patients have heterogeneous patterns of PKBPND in T1 BHs and indicate that BHs are not just "holes" representing loss of axons and myelin, but display inflammatory activity in the form of activated microglia. The significant association between PKBPND, neurological impairment and outcome in progressive subjects supports a role for activated microglia in disability progression.
Neurobiology of disease.Neurobiol Dis.2014 May;65:203-10. doi: 10.1016/j.nbd.2014.01.018. Epub 2014 Feb 6.
The pathophysiological correlates and the contribution to persisting disability of hypointense T1-weighted MRI lesions, black holes (BH), in multiple sclerosis (MS) are still unclear. In order to study the in vivo functional correlates of this MRI finding, we used 11C-PK11195 PET (PK-PET) to investi
PMID 24508617

Intracranial Plaque Enhancement in Patients with Cerebrovascular Events on High-Spatial-Resolution MR Images.

Qiao Y1, Zeiler SR, Mirbagheri S, Leigh R, Urrutia V, Wityk R, Wasserman BA.Author information 1From the Russell H. Morgan Department of Radiology and Radiological Sciences (Y.Q., S.M., B.A.W.) and Department of Neurology (S.R.Z., R.L., V.U., R.W.), Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 367 East Park Building, 600 N Wolfe St, Baltimore, MD 21287.AbstractPurpose To characterize intracranial plaque inflammation in vivo by using three-dimensional (3D) high-spatial-resolution contrast material-enhanced black-blood (BB) magnetic resonance (MR) imaging and to investigate the relationship between intracranial plaque inflammation and cerebrovascular ischemic events. Materials and Methods The study was approved by the institutional review board and was HIPAA compliant. Twenty-seven patients (19 men; mean age, 56.8 years ± 12.4 [standard deviation]) with cerebrovascular ischemic events (acute stroke, n = 20; subacute stroke, n = 2; chronic stroke, n = 3; transient ischemic attack, n = 2) underwent 3D time-of-flight MR angiography and contrast-enhanced BB 3-T MR imaging for intracranial atherosclerotic disease. Each identified plaque was classified as either culprit (the only or most stenotic lesion upstream from a stroke), probably culprit (not the most stenotic lesion upstream from a stroke), or nonculprit (not within the vascular territory of a stroke). Plaque contrast enhancement was categorized on BB MR images (grade 0, enhancement less than or equal to that of normal arterial walls seen elsewhere; grade 1, enhancement greater than grade 0 but less than that of the pituitary infundibulum; grade 2, enhancement greater than or equal to that of the pituitary infundibulum), and degree of contrast enhancement was calculated. Associations of the likelihood of being a culprit lesion with both plaque contrast enhancement and plaque thickness were estimated with ordinal logistic regression. Results Seventy-eight plaques were identified in 20 patients with acute stroke (21 [27%] culprit, 12 [15%] probably culprit, and 45 [58%] nonculprit plaques). In these patients, grade 2 contrast enhancement was associated with culprit plaques (odds ratio 34.6; 95% confidence interval: 4.5, 266.5 compared with grade 0) when adjusted for plaque thickness. Grade 0 was observed in only nonculprit plaques. Culprit plaques had a higher degree of contrast enhancement than did nonculprit plaques (25.9% ± 13.4 vs 13.6% ± 12.3, P = .003). Conclusion Contrast enhancement of intracranial atherosclerotic plaque is associated with its likelihood to have caused a recent ischemic event and may serve as a marker of its stability, thereby providing important insight into stroke risk. © RSNA, 2014 Online supplemental material is available for this article.
Radiology.Radiology.2014 May;271(2):534-42. doi: 10.1148/radiol.13122812. Epub 2014 Jan 16.
Purpose To characterize intracranial plaque inflammation in vivo by using three-dimensional (3D) high-spatial-resolution contrast material-enhanced black-blood (BB) magnetic resonance (MR) imaging and to investigate the relationship between intracranial plaque inflammation and cerebrovascular ischem
PMID 24475850

Japanese Journal

10年前に切除され，その後局所再発した手掌の悪性黒色腫の1例

土井直孝,三木田直哉,古川福実,山本有紀
Skin Cancer 29(3), 309-312, 2015
2001年ごろから右手掌に黒色斑が出現していた。2004年10月に精査のため当院を受診した。3 mm大の辺縁不整な黒色斑であり，精査のため4 mmパンチで切除生検され，病理組織診でbasal pigmentationの診断で治療終了となっていた。切除部は肉眼的には病変は消失し瘢痕となっていた。しかし，5年後に瘢痕から色素性病変が出現し当科受診となった。2013年11月に生検施行し，悪性黒色腫と診断 …
NAID 130005067555

Mortierella wolfii感染による新生子牛の壊死性小脳炎

山本敦子,信本聖子,小林亜由美,和田好洋,稲垣華絵,花房泰子,芝原友幸
日本獣医師会雑誌 68(2), 112-116, 2015
北海道内の黒毛和種牛飼養農場で，子牛1頭が出生直後から起立不能，後弓反張及び意識混濁等の神経症状を呈し，生後3日目で死亡した．剖検では，小脳の大部分の領域で出血と軟化が認められた．肝臓及び腎臓に白色結節が散見され，脾臓に赤色結節が1カ所みられた．組織学的に，小脳では出血性壊死性炎症がみられ，病変部には多数の真菌がみられた．肝臓，腎臓及び脾臓には壊死を伴う真菌の増殖と肉芽腫の形成がみられた．真菌の形 …
NAID 130004888076