加齢男性性腺機能低下症候群
WordNet
- of a later stage in the development of a language or literature; used especially of dead languages; "Late Greek"
- later than usual or than expected; "the train arrived late"; "we awoke late"; "the children came late to school"; "notice came so tardily that we almost missed the deadline"; "I belatedly wished her a happy birthday" (同)belatedly, tardily
- at or toward an end or late period or stage of development; "the late phase of feudalism"; "a later symptom of the disease"; "later medical science could have saved the child" (同)later
- of the immediate past or just previous to the present time; "a late development"; "their late quarrel"; "his recent trip to Africa"; "in recent months"; "a recent issue of the journal" (同)recent
- at an advanced age or stage; "she married late"; "undertook the project late in her career"
- being or occurring at an advanced period of time or after a usual or expected time; "late evening"; "late 18th century"; "a late movie"; "took a late flight"; "had a late breakfast"
- having died recently; "her late husband"
- the beginning or early stages; "the onset of pneumonia" (同)oncoming
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
- incompetence of the gonads (especially in the male with low testosterone); results in deficient development of secondary sex characteristics and (in prepubertal males) a body with long legs and a short trunk
- a genus of large percoid fishes of fresh and brackish water (同)genus Lates
PrepTutorEJDIC
- (定刻・通常・予定の時間より)『遅れた』,遅い / (時刻が)『遅い』,遅く始まる,遅くまで続く;夜更けの / (時期が)『遅い』,終りごろの,後期の / 『最近の』,最新の(recent) / 《the~,one's~》『前の』,先の,前任の(former) / 《the~,one's~》『故』…,つい先ごろ死んだ / (定刻などより)『遅れて』,遅く / (時刻が)『遅く』,遅くまで,(特に)夜更けに;(時期が)遅く,終りごろに / 『最近』,近ごろ(recently)
- 攻撃,襲撃 / (病気・季節などの)始まり,開始《+『of』+『名』》
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Association between late-onset hypogonadism syndrome plus metabolic syndrome and prostate cancer and its aggressiveness.
- Fuentes-Pastor J1, Pellejero P2, Ortiz I3, Ramírez-Backhaus M4, de Gracia A5, Marrugo C5, Gomez-Ferrer A5, Calatrava A6, Rubio-Briones J5, Rodriguez-Torreblanca C3, Solsona-Narbón E5.
- Actas urologicas espanolas.Actas Urol Esp.2016 Apr 15. pii: S0210-4806(16)00053-X. doi: 10.1016/j.acuro.2016.02.001. [Epub ahead of print]
- OBJECTIVE: To assess the relationship between prostate cancer (PC) and the presence of metabolic syndrome and late-onset hypogonadism (LOH) syndrome.MATERIAL AND METHOD: A retrospective study was conducted on 686 patients who underwent prostate biopsy. We analysed the demographic variables, clinical
- PMID 27091367
- Testosterone deficiency syndrome: benefits, risks, and realities associated with testosterone replacement therapy.
- Hassan J1, Barkin J.
- The Canadian journal of urology.Can J Urol.2016 Feb;23(1 Suppl 1):20-30.
- Testosterone deficiency syndrome, which has sometimes been termed age-related or late-onset hypogonadism, is a syndrome characterized by both clinical manifestations as well as a biochemical deficiency of testosterone. This condition is associated with considerable morbidity and mortality, accountin
- PMID 26924592
- EMAS position statement: Testosterone replacement therapy in the aging male.
- Dimopoulou C1, Ceausu I2, Depypere H3, Lambrinoudaki I4, Mueck A5, Pérez-López FR6, Rees M7, van der Schouw YT8, Senturk LM9, Simonsini T10, Stevenson JC11, Stute P12, Goulis DG13.
- Maturitas.Maturitas.2016 Feb;84:94-9. doi: 10.1016/j.maturitas.2015.11.003. Epub 2015 Nov 10.
- INTRODUCTION: Late-onset hypogonadism (LOH) represents a common clinical entity in aging males, characterized by the presence of symptoms (most usually of a sexual nature, such as decreased libido, decreased spontaneous erections and erectile dysfunction) and signs, in combination with low serum tes
- PMID 26614257
Japanese Journal
- LOH症候群およびGIDに対するARTの現状と展望 (シンポジウム 西日本におけるアンドロロジー)
- 西日本泌尿器科 = The Nishinihon journal of urology 77(6), 202-206, 2015-06
- NAID 40020496744
- Total testosterone is the most valuable indicator of metabolic syndrome among various testosterone values in middle-aged Japanese men
Related Links
- 1. Med Clin North Am. 2011 May;95(3):507-23, x. doi: 10.1016/j.mcna.2011.03.001. Late-onset hypogonadism. Bassil N. Late-onset hypogonadism is a clinical and biological syndrome associated with advancing age and characterized ...
- LOH syndrome(late-onset hypogonadism) とか男性更年期障害とか (12/30) categories IT (36) personal (324) 医療 (35) 映画(映像) (146) 音楽 (166) 原田芳雄 (24) 自転車 (34) 小説・漫画 (125) 創作 (37) 透析 (50 ) 泌尿器科 (125) ...
★リンクテーブル★
[★]
- 英
- Late-onset hypogonadism, Late-onset hypogonadism syndrome, LOH syndrome
- 同
- LOH症候群
- 関
- (X連鎖劣性遺伝疾患で眼症状、神経症状、腎障害を呈する)ロウ症候群, Lowe syndrome
概念
- 加齢による男性ホルモンの低下によりもたらされる種々の症状を包括した病態
有病率
- https://www.aska-pharma.co.jp/pdf/company/report14_4.pdf
- 遊離testosterone値が8.5 pg/ml未満、かつAMS総得点で中等度あるいは重度の症状を有する場合をLOHと定義
- 20歳代:0%、30歳代:2.8%、40歳代:5.9%、50歳代:13%、60歳代:25.6%、70歳代:26.6%
症状
- 骨密度の低下、筋力の低下、体脂肪率の増加、性腺機能低下、抑うつ症状、認知力低下
診断
- 正常: ≧11.8 pg/ml
- 境界域:8.5≦ <11.8 pg/ml
- 低値: <8.5 pg/ml
治療
アンドロゲン補充療法
- 参考1
- アンドロゲン補充療法の適応:LOH症状および徴候を有する40歳以上の男性かつ、血中遊離型テストステロン値が以下の場合
- 8.5pg/ml未満:ARTを第一に行う
- 8.5pg/ml以上11.8pg/ml未満:症状や徴候の程度や、ARTのリスクおよび有用性を説明し、治療選択肢の一つとする
- 11.8pg/ml以上:ARTは行わず、症状に応じて以下の治療を考慮する
- 性機能症状:PDE5阻害薬
- 精神・心理症状:精神神経科医・心療内科医と相談し、抗うつ薬・抗不安薬を投与する
- 身体症状:骨粗鬆症に対しては専門家と相談し薬物療法、筋力低下に対しては生活習慣の改善などを指導する
- 前立腺がん
- 治療前PSAが2.0ng/ml以上:ただし、2.0ng/ml以上4.0ng/ml未満の場合は慎重に検討し治療する
- 中等度以上の前立腺肥大症
- 乳がん
- 多血症
- 重度の肝機能障害
- 重度の腎機能不全
- うっ血性心不全
- 重度の高血圧
- 夜間睡眠時無呼吸
- (1)エナント酸テストステロン1回125mgを2~3週毎に、あるいは1回250mgを3~4週毎に筋注する
- (2)胎盤性性腺刺激ホルモン(hCG)1回3,000~5,000単位を週1~2回、あるいは2週間毎に筋注する.
- (3)男性ホルモン軟膏1回3gを1日1~2 回陰嚢皮膚に塗布(1回3mgテストステロン相当)
参考
- 1. 加齢男性性腺機能低下症候群(LOH症候群)診療の手引き
- https://www.urol.or.jp/info/data/gl_LOH.pdf
[★]
- 襲撃、攻撃。(病気などの)始まり、開始、襲来。着手、手始め
- 関
- affect、commence、commencement、develop、development、developmental、emergence、engender、episode、event、generate、generation、initiate、initiation、institute、mount、occur、occurrence、pathogenesis、start、symptom onset、transpire
[★]
- (比較級later-最上級latest)遅い、遅発の、遅発型の、晩発の、後の、後期の
- 関
- after、afterward、afterwards、anaphase、behind、delayed、following、late-stage、post、posterior、slow、subsequent
[★]
ランタン
- 関
- lanthanum
[★]