n.

病原、病原論、病因、病因論
発病、病原形性

WordNet

the origination and development of a disease
specify the origin of; "The writer carefully sourced her report"
(technology) a process by which energy or a substance enters a system; "a heat source"; "a source of carbon dioxide"
a facility where something is available
anything that provides inspiration for later work (同)seed, germ
a document (or organization) from which information is obtained; "the reporter had two sources for the story"
get (a product) from another country or business; "She sourced a supply of carpet"; "They are sourcing from smaller companies"
the beginning or early stages; "the onset of pneumonia" (同)oncoming
infectious; having the ability to cause disease
cause to continue or prevail; "perpetuate a myth"
the cause of a disease (同)aetiology
the philosophical study of causation (同)aetiology

PrepTutorEJDIC

(河川の)『水源』[『地』],源 / (物事の)『元』(もと),原因,根源《+『of』+『名』》 / 《しばしば複数形で》情報源,出所,典拠
攻撃,襲撃 / (病気・季節などの)始まり,開始《+『of』+『名』》
有毒な,毒性の / 憎悪に満ちた,敵意に満ちた
…‘を'永続さらる;…‘を'不朽のものにする
〈U〉病原学 / 〈C〉〈U〉病気の原因,病因

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/19 00:57:18」(JST)

wiki en

[Wiki en表示]

The pathogenesis of a disease is the biological mechanism (or mechanisms) that lead to the diseased state. The term can also describe the origin and development of the disease, and whether it is acute, chronic, or recurrent. The word comes from the Greek pathos ("disease") and genesis ("creation").

Types of pathogenesis include microbial infection, inflammation, malignancy and tissue breakdown. For example bacterial pathogenesis is the mechanism by which bacteria cause infectious illness.

Most diseases are caused by multiple processes. For example, certain cancers arise from dysfunction of the immune system (skin tumors and lymphoma after a renal transplant, which requires immunosuppression).^[1]^[2]

The pathogenetic mechanisms of a disease (or condition) are set in motion by underlying etiological causes, which if controlled would allow the disease to be prevented.^[3] Often, a potential etiology is identified by epidemiological observations before a pathological link can be drawn between the cause and the disease. The pathological perspective can be directly integrated into an epidemiological approach in the interdisciplinary field of molecular pathological epidemiology (MPE).^[4] MPE can help to assess pathogenesis and causality by means of linking a potential etiologic factor to molecular pathologic signatures of a disease.^[5] Thus, the MPE paradigm can advance the area of causal inference.

References

^ Fox A (2010). General aspects of bacterial pathogenesis. University of South Carolina School of Medicine: Microbiology and Immunology On-line Textbook.
^ Miquel Porta, Greenland S, Hernán M, dos Santos Silva I, Last JM, ed. (2014). ['http://global.oup.com/academic/product/a-dictionary-of-epidemiology-9780199976737?cc=us&lang=en A dictionary of epidemiology.] (6th ed.). Oxford: Oxford University Press. ISBN 9780199976737.
^ Last, JM, ed. (2000). A Dictionary of Epidemiology (4th ed.). Oxford: Oxford University Press. p. 132. ISBN 978-0-19-977434-0.
^ Ogino S, Stampfer M (2010). "Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology". J. Natl. Cancer Inst. 102 (6): 365–7. doi:10.1093/jnci/djq031. PMC 2841039. PMID 20208016.
^ Ogino S, Chan AT, Fuchs CS, Giovannucci E (2011). "Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary field". Gut 60 (3): 397–411. doi:10.1136/gut.2010.217182. PMC 3040598. PMID 21036793.

UpToDate Contents

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1. 細菌性髄膜炎の病因および病態生理 pathogenesis and pathophysiology of bacterial meningitis
2. 成人における慢性膵炎の病因および発症機序 etiology and pathogenesis of chronic pancreatitis in adults
3. アルコール性肝疾患の病因 pathogenesis of alcoholic liver disease
4. 骨盤内炎症性疾患：病因、微生物学、および危険因子 pelvic inflammatory disease pathogenesis microbiology and risk factors
5. 痛風性関節炎の病態生理 pathophysiology of gouty arthritis

English Journal

Nail apparatus melanoma: is trauma a coincidence? Is this peculiar tumor a real acral melanoma?

Fanti PA, Dika E, Misciali C, Vaccari S, Barisani A, Piraccini BM, Cavrin G, Maibach HI, Patrizi A.SourceInternal Medicine Aging and Nephrologic Disease Department, Dermatology Division, Ospedale Sant'Orsola-Malpighi, Università degli Studi di Bologna, Bologna, Italy.
Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2013 Jun;32(2):150-3. doi: 10.3109/15569527.2012.740118.
Nail Apparatus Melanoma (NAM) is rare, particularly in Caucasians. Understanding its pathogenesis and collecting epidemiologic data may be difficult due to its location and the exiguity of the case series of this cancer. Cutaneous melanoma has been thought related to UV radiation, and NAM is conside
PMID 23153047

Contact sensitivity in Behçet's disease.

Demirsoy EO, Kiran R, Oztürk B, Aktürk AS, Etiler N.SourceKocaeli University Medical Faculty, Dermatology, Kocaeli, Turkey. evrenodyakmaz@yahoo.com
Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2013 Jun;32(2):112-4. doi: 10.3109/15569527.2012.716886. Epub 2012 Sep 6.
CONTEXT: Behçet's disease (BD) is a multisystemic inflammatory disorder with unknown etiology. Many immunological changes were reported in BD previously and these changes may affect the frequency of contact sensitivity in these patients. Objective: We aimed to identify whether there is an interacti
PMID 22950639

Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus.

Young NA, Friedman AK, Kaffenberger B, Rajaram MV, Birmingham DJ, Rovin BH, Hebert LA, Schlesinger LS, Wu LC, Jarjour WN.SourceDivision of Rheumatology and Immunology, College of Medicine, The Ohio State University, Columbus, OH 43210, USA; Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Molecular immunology.Mol Immunol.2013 May;54(1):23-31. doi: 10.1016/j.molimm.2012.10.026. Epub 2012 Nov 22.
Systemic lupus erythematosus (SLE) is a prototypic, inflammatory autoimmune disease characterized by significant gender bias. Previous studies have established a role for hormones in SLE pathogenesis, including the sex hormone estrogen. Estrogen regulates gene expression by translocating estrogen re
PMID 23178823

Japanese Journal

慢性腎臓病の病態形成と酸化ストレス (AYUMI 慢性低酸素状態の腎臓)

柏原直樹,城所研吾,庵谷千恵子
医学のあゆみ 244(4), 297-302, 2013-01-26
NAID 40019552564

糖尿病性神経障害の成因研究の進歩 (AYUMI 糖尿病性神経障害Update)

八木橋操六,水上浩哉
医学のあゆみ 244(2), 139-145, 2013-01-12
NAID 40019538871

好酸球性副鼻腔炎の病態と治療 (特集最新の鼻・副鼻腔疾患診療)

岡野光博
日本医師会雑誌 141(10), 2191-2194, 2013-01
NAID 40019550420

Related Pictures

★リンクテーブル★

リンク元	「have a bearing on」「onset」「virulent」「原因」「perpetuate」
拡張検索	「disease pathogenesis」「immunopathogenesis」「etiopathogenesis」

「have a bearing on」

	Library resources about; pathogenesis
	Resources in your library;

　　[★]

～に影響/関係する、～にかかわりがある

ex.

The model may have a bearing on other types of pancreatitis as elevated cytosolic calcium is thought to be an early event in the pathogenesis of acute pancreatitis in general.(本研究のモデルは一般に急性膵炎の発症の早期イベントと考えられている細胞内カルシウム濃度の上昇のような他のタイプの膵炎に関わるがあるのかも知れない)

「onset」

　　[★]

n.

襲撃、攻撃。(病気などの)始まり、開始、襲来。着手、手始め

関: affect、commence、commencement、develop、development、developmental、emergence、engender、episode、event、generate、generation、initiate、initiation、institute、mount、occur、occurrence、pathogenesis、start、symptom onset、transpire

「virulent」

　　[★]

adj.

猛毒な、有毒な。毒気を含む、悪意に満ちた、憎しみに燃えた。毒々しい、どぢつい、苛酷な。(医)悪性の。(菌)毒性の

Fukuda says this particular strain of swine flu could become more or less virulent over time.

関: pathogenesis、pathogenetic、pathogenic、pathogenicity、toxic、toxicity、virulence

「原因」

　　[★]

英: cause、source、(病気の)etiology、pathogenesis、causal、due to
関: ソース、ために、引き起こす、必然的、病因学、病因論、病原、病原性、理由、出所、原料、源、発病、原因となる、せい、成因、供給源、病変形成

「perpetuate」

　　[★]

vt.

永続させる、永存させる。

Moreover, there are experimental and clinical data that colonic bacteria may either initiate or perpetuate the inflammation of IBD, and recent studies have implicated specific bacterial antigens in the pathogenesis of Crohn's disease.