Fas

同

CD95

WordNet

1. a genus of Fasciolidae (同)genus Fasciolopsis
2. (Judaism) a minor fast day on Tevet 10 commemorates the beginning of the siege of Jerusalem and has also been proclaimed a memorial day for the six million Jews who died in the Holocaust
3. (Judaism) a minor fast day on Nissan 14 that is observed only by firstborn males; it is observed on the day before Passover
4. the 6th letter of the Roman alphabet (同)f

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/24 05:23:44」(JST)

wiki en

[Wiki en表示]

Fas or FAS may refer to:

Businesses

• Fiat Automobili Srbija, an automobile-manufacturing company based in Kragujevac, Serbia
• Film Authors' Studio, a Croatian film-production company

Organizations

In research and academia

• Architecture and Surveying Institute, formerly the Faculty of Architects and Surveyors
• Faculty of Arts and Science:
  • Harvard Faculty of Arts and Sciences
  • University of Toronto Faculty of Arts and Science
• Federation of American Scientists, a non-profit organization formed in 1945 by scientists from the Manhattan Project
• Federation of Astronomical Societies, an international union of astronomical societies, formed in 1974

In sport

• Football Association of Serbia
• Football Association of Singapore
• Club Deportivo FAS, a Salvadoran football club

Other organizations

• Femmes Africa Solidarité, an NGO founded in 1996
• Foras Áiseanna Saothair, a state agency in Ireland responsible for employment assistance
• Foreign Agricultural Service, a service of the U.S. Department of Agriculture with primary responsibility for overseas programs
• Freedom and Solidarity, a conservative liberal political party in Slovakia
• Fuerzas Armadas de España, the Spanish Armed Forces

Places

• Fes, Morocco, the third-largest city in Morocco, as an alternate spelling
• Poti, Georgia, a port city in Georgia

In science and technology

In biology and medicine

• Fas receptor, also known as CD95, a receptor protein of the TNF receptor family that induces apoptosis on binding the Fas ligand
• Fatty acid synthase, an enzyme in humans
• Fetal alcohol syndrome, a birth-defect caused by overconsumption of alcohol during pregnancy
• Foreign accent syndrome, a medical condition whereby a person acquires an accent when speaking their native language, usually as a result of brain damage

Other uses in science and technology

• Fabric-attached storage, for computer data
• Feedback arc set, a concept in graph theory
• Ferrous Ammonium Sulfate or Mohr's Salt, a light green crystalline solid with the formula Fe(SO₄)₂(NH₄)₂.6H₂O (CAS number: 10045-89-3)
• Final assembly schedule, schedule for items to finish in a make-to-order (MTO) or assemble-to-order (ATO) environment
• Forced Auto Stop, a hypermiling technique involving turning off an automobile's internal combustion engine, shifting into neutral and coasting down hills to reduce gasoline use

Other uses

• Fas, Latin for "permissible" or "right", a concept of ancient Roman religion
• Federal Aid Highway System, roads built in the United States with funds provided by the federal government
• Financial Accounting Standard, a standard determined by the Financial Accounting Standards Board
• Free African Society, an 18th-century African-American community
• Free Alongside Ship, in trade, an International Commercial Term

See also

• Fass (disambiguation)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 胎児性アルコールスペクトラム障害：臨床的特徴および診断 fetal alcohol spectrum disorder clinical features and diagnosis
• 2. 鎌状赤血球障害の診断 diagnosis of sickle cell disorders
• 3. アルコール摂取と妊娠 alcohol intake and pregnancy
• 4. 自己免疫性リンパ増殖症候群(ALPS)：疫学および病因 autoimmune lymphoproliferative syndrome alps epidemiology and pathogenesis
• 5. 鎌状赤血球形質 sickle cell trait

English Journal

• Identification of a methylation hotspot in the death receptor Fas/CD95 in bladder cancer.

• Watson CJ, O'Kane H, Maxwell P, Sharaf O, Petak I, Hyland PL, O'Rouke D, McKnight J, Canning P, Williamson K.SourceCentre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, Northern Ireland, UK.
• International journal of oncology.Int J Oncol.2012 Mar;40(3):645-54. doi: 10.3892/ijo.2011.1250. Epub 2011 Nov 4.
• We characterized Fas immunoreactivity, function-ality and its role in the response to mitomycin‑C (MMC) chemotherapy in vitro in cell lines and in vivo in bladder washings from 23 transitional cell carcinoma of the bladder (TCCB) patients, harvested prior to a
• PMID 22076446

• PPARγ potentiates anticancer effects of gemcitabine on human pancreatic cancer cells.

• Koga H, Selvendiran K, Sivakumar R, Yoshida T, Torimura T, Ueno T, Sata M.SourceDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
• International journal of oncology.Int J Oncol.2012 Mar;40(3):679-85. doi: 10.3892/ijo.2011.1237. Epub 2011 Oct 20.
• In order to improve the prognosis of patients with unresectable pancreatic cancer, there is an urgent need for enhancement of the anticancer effect of gemcitabine (Gem), a first-line drug for the disease. Here, we demonstrated that ligands for peroxisome prolifera
• PMID 22020928

• Production system and slaughter age effects on intramuscular fatty acids from young Tudanca bulls.

• Humada MJ, Serrano E, Sañudo C, Rolland DC, Dugan ME.SourceCentro de Investigación y Formación Agrarias (C.I.F.A.), Gobierno de Cantabria, C/Héroes 2 de mayo, 27, 39600, Muriedas, Cantabria, Spain.
• Meat science.Meat Sci.2012 Mar;90(3):678-85. Epub 2011 Oct 31.
• Thirty-three young bulls from Tudanca local breed were used to investigate the effect of two production systems (semi-extensive vs. intensive) and two slaughter ages (12 vs. 14months) on meat fatty acid (FA) composition. Longissimus thoracis from semi-extensive animals had a lower percentage of intr
• PMID 22104254

Japanese Journal

• Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis

• Shimizu Yasuo,Dobashi Kunio,Nagase Hiroyuki,Ohta Ken,Sano Takaaki,Matsuzaki Shinichi,Ishii Yoshiki,Satoh Takahiro,Koka Masashi,Yokoyama Akihito,Ohkubo Takeru,Ishii Yasuyuki,Kamiya Tomihiro
• Journal of Clinical Biochemistry and Nutrition, 2015
• … Immunohistochemical examination for Fas and p62 protein expression was performed using lung tissue specimens. … Fas and p62 were expressed by histiocytes in granulomas on day 7, and the expressions persisted for day 56. … Fas- and p62-expressing histiocytes were co-localized in granulomas with silica particles that showed an increase of iron levels on silica particles in mouse lungs. …
• NAID 130004704980

• High Throughput Analysis of Cerebrosides from the Sea Cucumber Pearsonothria graeffei by Liquid Chromatography—Quadrupole-Time-of-Flight Mass Spectrometry

• Jia Zicai,Li Shiyan,Cong Peixu,Wang Yuming,Sugawara Tatsuya,Xue Changhu,Xu Jie
• Journal of Oleo Science, 2015
• … The carbon numbers of fatty acids (FAs) were mainly 18~24, while 24 carbon fatty acids were predominant. …
• NAID 130004704216

• A Strong Correlation between Serum soluble IL-2 Receptor (sIL-2R) and Atypical Lymphocytosis

• Nakashima Kazuhisa,Toku Yuichiro,Matsuda Kazuyuki,Kamihira Shimeru,Kanematsu Takashi
• Acta medica Nagasakiensia 59(2), 57-62, 2014-12
• … These activated cells release various cytokines or soluble receptors such as soluble interleukin-2 receptor (sIL-2R) and Fas-receptor (Fas-R). …
• NAID 120005522363

Related Links

• 一般社団法人 福岡県自動車整備振興会｜FAS

（一社）福岡県自動車整備振興会(FAS) 〒812-0051 福岡市東区箱崎ふ頭6丁目7番16号 TEL（092）641-3171／FAX（092）641-3178 ... FASって何？ | アクセス | インフォメーション | 車検のあれこれ | 整備士のお仕事とは？ | 日常点検をしよう ...

• FAS Decolog｜ブログ始めるなら無料ブログ ファスデコログ

10代～20代の女性に人気の無料ブログサービス。女子のリアルなイキザマ残すならファスデコログ。 ... すっぴん隠し用のカラコン！着けてることを忘れてしまうぐらいな付け心地だから、普段使いに最適

Related Pictures

---

★リンクテーブル★

リンク元	「キラーT細胞」「サイトカイン受容体」「自己免疫性リンパ増殖症候群」「CD95」
拡張検索	「Fas receptor」「Fas結合デスドメインタンパク質」「Fas-associated death domain protein」「FasL」
関連記事	「FAS」「F」

「キラーT細胞」

　　[★]

英

killer T cell

同

細胞傷害性T細胞 cytotoxic T cell 、細胞溶解性T細胞 cytolytic T cell、細胞傷害性Tリンパ球 cytotoxic T lymphocyte CTL、細胞溶解性Tリンパ球 cytolytic T lymphocyte CTL

関

ヘルパーT細胞、T細胞、ラック細胞 LAK細胞

同

KT

• 偏性細胞内寄生体であるウイルス感染において特に誘導されやすい (SMB.47)

機能

• キラーT細胞のTCRが、抗原を提示しているMHC class Iを認識し、キラーT細胞のCD8がMHC class Iとの結合を増強して、細胞傷害を行う (SP.250)
• 攻撃の方法は２つあり、リソソームから酵素を注入する方法と、パーフォリン(perforin)を注入する方法とがある (SP.250)

抗原認識と細胞傷害 (SMB.48)

• 1. キラーT細胞のTCRがが抗原を提示したMHC class Iを認識
• 2. CD8がMHC class Iに結合
• 3. キラーT細胞で発現しているLFA-1が標的細胞のICAM-1と結合
• 4. キラーT細胞がFasリガンドを発現し、標的細胞のFasに結合
• 5. パーフォリンが放出される
• 6. グランザイムが注入される

新しいトピック

• グラニュライシン, granulysin (SMB.48)

結核菌の殺傷に関与

-細胞傷害性T細胞

「サイトカイン受容体」

　　[★]

英

cytokine receptor

関

サイトカイン

• 多ユニット構造を取ることが特徴である。

サイトカイン受容体ファミリー

• 細胞外領域に200a.a.からなる共通構造を有する。

• HRF motif, hematopoietin receptor family motif

• 細胞外領域のN末側に4つのCysが存在
• 細胞外領域の膜貫通部位付近にWSXWSモチーフが存在

shared γc	IL-2, IL-4, IL-7, IL-9, IL-13, IL-15
shared gp130	IL-6, G-CSF, IL-11, IL-12, LIF, OSM, CNTF
shared gp140	IL-3, IL-5, GM-CSF

チロシンキナーゼファミリー

• TKF motif(tyrosine kinase family motif)
• EGF, PDGF, FGF, SCF

IL-1受容体ファミリー

• TLRと共通領域がある
• IL-1

TNF受容体ファミリー

• death domainを持つ
• TNF, Fas, CD40, CD30

ケモカイン受容体ファミリー

• ７回膜貫通型
• ケモカイン受容体
• IL-8, MCP

「自己免疫性リンパ増殖症候群」

　　[★]

英

autoimmune lymphoproliferative syndrome ALPS

関

アポトーシス

遺伝

• 常染色体劣性遺伝

原因

• Fas, FasL, FasL signal transductionの異常によりリンパ球がアポトーシスを起こさない

• Fas(Ia型)
• FasL(Ib型)
• caspase-10(II型)

症状

• リンパ節腫大
• 肝脾腫
• 自己免疫性疾患（溶血性貧血、血小板減少症、好中球減少症、糸球体腎炎、自己免疫性肝炎、皮疹など）

治療

• 副腎皮質ステロイド
• 免疫抑制薬
• 骨髄移植

「CD95」

　　[★]

同

Fas antigen, APO-1. Tumor necrosis factor receptor family, member 6

関

Fas、Fas抗原

「Fas receptor」

　　[★]

Fas受容体、Fasレセプター

関

APO-1 antigen、CD95 antigen、Fas antigen

「Fas結合デスドメインタンパク質」

　　[★]

英

Fas-associated death domain protein、FADD protein

関

FADDタンパク質

「Fas-associated death domain protein」

　　[★]

Fas結合デスドメインタンパク質

関

FADD protein

「FasL」

　　[★]

• Fasリガンド

関

Fas ligand

「FAS」

　　[★]

• 胎児性アルコール症候群 fetal alcohol syndrome
• 脂肪酸合成酵素 fatty acid synthetase：fatty acid synthetase 1、fatty acid synthetase 2
• (アポトーシスに関連)CD95 Fas

「F」

　　[★] フェニルアラニン phenylalanine