- 同
- DD
WordNet
- the time when something ends; "it was the death of all his plans"; "a dying of old hopes" (同)dying, demise
- the time at which life ends; continuing until dead; "she stayed until his death"; "a struggle to the last" (同)last
- the absence of life or state of being dead; "he seemed more content in death than he had ever been in life"
- the permanent end of all life functions in an organism or part of an organism; "the animal died a painful death"
- the act of killing; "he had two deaths on his conscience"
- the event of dying or departure from life; "her death came as a terrible shock"; "upon your decease the capital will pass to your grandchildren" (同)decease, expiry
- territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
- (mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function
- the personification of death; "Death walked the streets of the plague-bound city"
PrepTutorEJDIC
- dishonorable discharge
- 〈U〉〈C〉『死』,死亡;死に方,死にざま / 〈U〉死んだ[ような]状体 / 《the~》(…の)絶滅,破滅《+『of』+『名』》 / 《the~》(…の)死の原因,命取り《+『of』+『名』》 / 《通例『D-』》死神(手に鎌(かマ)を持った黒装束の骸骨(がいこつ)で表される)
- (国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/22 22:30:42」(JST)
[Wiki en表示]
Death domain |
Structure of the Fas (APO-1/CD95) death domain.[1]
|
Identifiers |
Symbol |
Death |
Pfam |
PF00531 |
InterPro |
IPR000488 |
SMART |
DEATH |
PROSITE |
PDOC50017 |
SCOP |
1ddf |
SUPERFAMILY |
1ddf |
CDD |
cd01670 |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe; PDBj |
PDBsum |
structure summary |
|
The death domain (DD) is a protein interaction module composed of a bundle of six alpha-helices. DD is a subclass of protein motif known as the death fold and is related in sequence and structure to the death effector domain (DED) and the caspase recruitment domain (CARD), which work in similar pathways and show similar interaction properties.[2] DD bind each other forming oligomers. Mammals have numerous and diverse DD-containing proteins.[3] Within these proteins, the DD domains can be found in combination with other domains, including: CARDs, DEDs, ankyrin repeats, caspase-like folds, kinase domains, leucine zippers, leucine-rich repeats (LRR), TIR domains, and ZU5 domains.[4]
Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB, which typically involves interactions with TNF (tumour necrosis factor) cytokine receptors.[5][6] In humans, eight of the over 30 known TNF receptors contain DD in their cytoplasmic tails; several of these TNF receptors use caspase activation as a signaling mechanism. The DD mediates self-association of these receptors, thus giving the signal to downstream events that lead to apoptosis. Other DD-containing proteins, such as ankyrin, MyD88 and pelle, are probably not directly involved in cell death signalling. DD-containing proteins also have links to innate immunity, communicating with Toll-like receptors through bipartite adapter proteins such as MyD88.[7]
See also
References
- ^ Huang B, Eberstadt M, Olejniczak ET, Meadows RP, Fesik SW (1996). "NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain". Nature 384 (6610): 638–41. doi:10.1038/384638a0. PMID 8967952.
- ^ Weber CH, Vincenz C (August 2001). "The death domain superfamily: a tale of two interfaces?". Trends Biochem. Sci. 26 (8): 475–81. doi:10.1016/S0968-0004(01)01905-3. PMID 11504623.
- ^ Feinstein E, Kimchi A, Wallach D, Boldin M, Varfolomeev E (September 1995). "The death domain: a module shared by proteins with diverse cellular functions". Trends Biochem. Sci. 20 (9): 342–4. doi:10.1016/S0968-0004(00)89070-2. PMID 7482697.
- ^ Reed JC, Doctor KS, Godzik A (June 2004). "The domains of apoptosis: a genomics perspective". Sci. STKE 2004 (239): re9. doi:10.1126/stke.2392004re9. PMID 15226512.
- ^ Wajant H (2003). "Death receptors". Essays Biochem. 39: 53–71. PMID 14585074.
- ^ Bhardwaj A, Aggarwal BB (September 2003). "Receptor-mediated choreography of life and death". J. Clin. Immunol. 23 (5): 317–32. doi:10.1023/A:1025319031417. PMID 14601641.
- ^ O'Neill LA, Dunne A, Edjeback M, Gray P, Jefferies C, Wietek C (2003). "Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors". J. Endotoxin Res. 9 (1): 55–9. doi:10.1179/096805103125001351. PMID 12691620.
This article incorporates text from the public domain Pfam and InterPro IPR000488
UpToDate Contents
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English Journal
- --Depletion of Amyloid Precursor Protein (APP) Causes G0 Arrest in Non-Small Cell Lung Cancer (NSCLC) Cells.
- Sobol A1, Galluzzo P, Weber MJ, Alani S, Bocchetta M.
- Journal of cellular physiology.J Cell Physiol.2015 Jun;230(6):1332-41. doi: 10.1002/jcp.24875.
- We recently reported that Amyloid Precursor Protein (APP) regulates global protein synthesis in a variety of human dividing cells, including non-small cell lung cancer (NSCLC) cells. More specifically, APP depletion causes an increase of both cap- and IRES-dependent translation. Since growth and pro
- PMID 25502341
- Identification, expression pattern and functional characterization of As-MyD88 in bacteria challenge and during different developmental stages of Artemia sinica.
- Qin T1, Zhao X1, Luan H1, Ba H1, Yang L1, Li Z1, Hou L2, Zou X3.
- Developmental and comparative immunology.Dev Comp Immunol.2015 May;50(1):9-18. doi: 10.1016/j.dci.2014.12.013. Epub 2014 Dec 30.
- Myeloid differentiation factor 88 (MYD88), a key adapter protein in Toll-like receptor signaling, affects the immune response and the formation of the dorsal-ventral axis. Here, the 1555bp full-length cDNA of MyD88 from Artemia sinica (As-MyD88) was obtained. Molecular characterization revealed that
- PMID 25556009
- New therapeutic perspectives in CCDC6 deficient lung cancer cells.
- Morra F1, Luise C, Visconti R, Staibano S, Merolla F, Ilardi G, Guggino G, Paladino S, Sarnataro D, Franco R, Monaco R, Zitomarino F, Pacelli R, Monaco G, Rocco G, Cerrato A, Linardopoulos S, Muller MT, Celetti A.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 May 1;136(9):2146-57. doi: 10.1002/ijc.29263. Epub 2014 Oct 24.
- Non-small cell lung cancer (NSCLC) is the main cause of cancer-related death worldwide and new therapeutic strategies are urgently needed. In this study, we have characterized a panel of NSC lung cancer cell lines for the expression of coiled-coil-domain containing 6 (CCDC6), a tumor suppressor gene
- PMID 25302833
Japanese Journal
- 讃岐高松藩における「死の政治学」と幕藩制的社会秩序の維持強化(下) : 服忌令等葬送儀礼関連法令の政治文化史的役割を問うなかで
- タイ国における中国系善堂の宗教活動 : 泰国義徳善堂に見る中国系宗教とタイ仏教
- 片岡 樹
- 東南アジア研究 52(2), 172-207, 2015-01-31
- … However, Ngi Tek Tungʼs emphasis on religiosity has been declining after the founderʼs death, which means the extinction of the tradition of the spirit medium cult. … Todayʼs Ngi Tek Tung can be viewed both as a secular foundation to encompass the religious domain and as a religious organization engaged in profane activities. …
- NAID 120005603908
- タイ国における中国系善堂の宗教活動: 泰国義徳善堂に見る中国系宗教とタイ仏教
- 片岡 樹
- 東南アジア研究 52(2), 172-207, 2015-01-31
- … However, Ngi Tek Tung's emphasis on religiosity has been declining after the founder's death, which means the extinction of the tradition of the spirit medium cult. … Today's Ngi Tek Tung can be viewed both as a secular foundation to encompass the religious domain and as a religious organization engaged in profane activities. …
- NAID 110009873213
Related Links
- ドメインの結合および機能 DD(Death domains; デスドメイン)は80–100残基の長さからなるモチーフで、アポトーシスのシグナル伝達に関与する。それらは細胞質タンパク質と、腫瘍壊死因子受容体(tumor necrosis factor receptor)スーパー ...
- Death Domain
Related Pictures
★リンクテーブル★
[★]
- 英
- cytokine receptor
- 関
- サイトカイン
サイトカイン受容体ファミリー
- 細胞外領域に200a.a.からなる共通構造を有する。
- HRF motif, hematopoietin receptor family motif
- 細胞外領域のN末側に4つのCysが存在
- 細胞外領域の膜貫通部位付近にWSXWSモチーフが存在
shared γc
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IL-2, IL-4, IL-7, IL-9, IL-13, IL-15
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shared gp130
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IL-6, G-CSF, IL-11, IL-12, LIF, OSM, CNTF
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shared gp140
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IL-3, IL-5, GM-CSF
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チロシンキナーゼファミリー
IL-1受容体ファミリー
TNF受容体ファミリー
ケモカイン受容体ファミリー
[★]
- 英
- death domain
リガンドTNFやFasLは3量体を形成しており、2量体のそれぞれTNFR, Fasに結合してデスドメインを持つcaspaseを活性化し、CAD(endonuclease)を介してapoptosisを実行する?
[★]
- 関
- death receptor
[★]
[★]
TNF受容体関連デスドメインタンパク質
- 関
- TRADD
[★]
Fas結合デスドメインタンパク質
- 関
- FADD protein
[★]
- 関
- area、realm、region、regional、segregation、territory、universe
[★]
[★]
- 関
- See also specific type