全身性副作用、全身的副作用

WordNet

take sides for or against; "Who are you widing with?"; "I"m siding against the current candidate"
an extended outer surface of an object; "he turned the box over to examine the bottom side"; "they painted all four sides of the house"
a surface forming part of the outside of an object; "he examined all sides of the crystal"; "dew dripped from the face of the leaf" (同)face
an opinion that is held in opposition to another in an argument or dispute; "there are two sides to every question" (同)position
a lengthwise dressed half of an animals carcass used for food (同)side of meat
a family line of descent; "he gets his brains from his fathers side"
a line segment forming part of the perimeter of a plane figure; "the hypotenuse of a right triangle is always the longest side"
a place within a region identified relative to a center or reference location; "they always sat on the right side of the church"; "he never left my side"
an aspect of something (as contrasted with some other implied aspect); "he was on the heavy side"; "he is on the purchasing side of the business"; "it brought out his better side"
either the left or right half of a body; "he had a pain in his side"
one of two or more contesting groups; "the Confederate side was prepared to attack"
located on a side; "side fences"; "the side porch"
(physical chemistry) a sample of matter in which substances in different phases are in equilibrium; "in a static system oil cannot be replaced by water on a surface"; "a system generating hydrogen peroxide"
instrumentality that combines interrelated interacting artifacts designed to work as a coherent entity; "he bought a new stereo system"; "the system consists of a motor and a small computer"
a group of independent but interrelated elements comprising a unified whole; "a vast system of production and distribution and consumption keep the country going" (同)scheme
a complex of methods or rules governing behavior; "they have to operate under a system they oppose"; "that language has a complex system for indicating gender" (同)system of rules
a group of physiologically or anatomically related organs or parts; "the body has a system of organs for digestion"
a procedure or process for obtaining an objective; "they had to devise a system that did not depend on cooperation"
the living body considered as made up of interdependent components forming a unified whole; "exercise helped him get the alcohol out of his system"
act so as to bring into existence; "effect a change"
a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic"
(of a law) having legal validity; "the law is still in effect" (同)force
the central meaning or theme of a speech or literary work (同)essence, burden, core, gist
an impression (especially one that is artificial or contrived); "he just did it for effect"
produce; "The scientists set up a shock wave" (同)effectuate, set_up
material applied to the outside of a building to make it weatherproof
a short stretch of railroad track used to store rolling stock or enable trains on the same line to pass (同)railroad siding, turnout, sidetrack
affecting an entire system; "a systemic poison"

PrepTutorEJDIC

(物体)『面』 / (物体の)『側面』,わき / (紙・レコードなど平らな物の)『面』 / (中心線・分離線から見た)『片側』 / (中心部分から見て)…『側』 / (人間・動物の体の右または左の)『側面』,(特に)横腹,わき腹 / 《単随形で》(人の)『そば』,わき / (物の)端,へり;(図形の)辺 / (競技・争いなどの一方の)『側』,味方 / (事柄の持っている)一面,局面 / (父方または母方の)血統,…方(かた) / 側部の,側面の,わきの / 側部(側面)からの(への) / 二次的な,従の / 〈建物など〉‘に'側面を付ける / (…に賛成の(反対の))側につく《+『with(against)』+『名』》
〈C〉(関連した部分から成る)『体系』,系統,組織[網],装置 / 〈C〉(教育・政治などの)『制度』,機構;《the~》体制 / 〈C〉(思想・学問などの)『体系』,学説 / 〈C〉(…の)『方法』,方式,やり方《+of doing》 / 〈U〉正しい方針(筋道,順序) / 〈U〉《the~》(身体の)組織,系統 / 〈U〉《the~,one's~》身体,全身
〈C〉〈U〉『結果』 / 〈C〉〈U〉(…への)『効果』,効きめ,影響《+『on』(『upon』)+『名』》 / 〈C〉(色・音・形などの)印象,感銘 / 《複数形で》品物;身の回り品;動産,財産 / (結果として)…‘を'『もたらす』;〈目的など〉‘を'果たす,遂行する
〈C〉(鉄道の)側線,待避線 / 〈U〉《米》(木造家屋外壁の)下見張り,(建物の外側の)壁板
(身体・言語のように)体系の,組織の / 全身の,全身的

UpToDate Contents

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1. 成人における全身性硬化症（強皮症）の診断および鑑別診断 diagnosis and differential diagnosis of systemic sclerosis scleroderma in adults
2. 非選択性非ステロイド性抗炎症剤（NSAIDs）：副作用の概要 nonselective nsaids overview of adverse effects
3. 成人における全身性硬化症（強皮症）の臨床症状の概要 overview of the clinical manifestations of systemic sclerosis scleroderma in adults
4. ステロイドの全身投与の主な副作用 major side effects of systemic glucocorticoids
5. 若年性全身性硬化症（強皮症） juvenile systemic sclerosis scleroderma

English Journal

Intestinal epithelial cell transported TLR2 ligand stimulates Ly6C(+) monocyte differentiation in a G-CSF dependent manner.

Hiemstra IH1, Vrijland K1, Hogenboom MM1, Bouma G2, Kraal G1, den Haan JM3.
Immunobiology.Immunobiology.2015 Nov;220(11):1255-65. doi: 10.1016/j.imbio.2015.06.015. Epub 2015 Jun 26.
Microflora-induced TLR signaling in the intestinal epithelium is essential for a proper intestinal barrier function. Because of the close interactions of this epithelial layer with underlying mononuclear phagocytes, we hypothesized that epithelial TLR signaling may affect the differentiation of myel
PMID 26143228

Effectiveness and Safety of Anakinra for Management of Refractory Pericarditis.

Jain S1, Thongprayoon C2, Espinosa RE1, Hayes SN1, Klarich KW1, Cooper LT1, Moder KG3, Anavekar NS1, Oh JK2, Matteson EL4.
The American journal of cardiology.Am J Cardiol.2015 Oct 15;116(8):1277-9. doi: 10.1016/j.amjcard.2015.07.047. Epub 2015 Jul 29.
Recurrent pericarditis is a debilitating condition that can be recalcitrant to conventional therapy with nonsteroidal anti-inflammatory agents, colchicine, and glucocorticoids. The aim of this study was to evaluate the therapeutic role of the recombinant interleukin-1 receptor antagonist anakinra in
PMID 26279106

A dual pH/thermal responsive nanocarrier for combined chemo-thermotherapy based on a copper-doxorubicin complex and gold nanorods.

Lei M1, Ma M, Pang X, Tan F, Li N.
Nanoscale.Nanoscale.2015 Oct 14;7(38):15999-6011. doi: 10.1039/c5nr04353k. Epub 2015 Sep 15.
The development of treatment protocols that results in a complete response to chemotherapy has been hampered by low efficacy and systemic toxicity. Here, we created a pH sensitive copper-doxorubicin complex within the core of temperature-sensitive liposomes to maintain the stability during blood cir
PMID 26370706

Japanese Journal

A case of probable Vogt-Koyanagi-Harada disease in a 3-year-old girl

Katsuyama Atsuko,Kusuhara Sentaro,Awano Hiroyuki,Nagase Hiroaki,Matsumiya Wataru,Nakamura Makoto
BMC Ophthalmology 19(1), 179, 2019-08-13
… Background Vogt-Koyanagi-Harada (VKH) disease is a T-cell-mediated autoimmune disorder characterized by bilateral granulomatous panuveitis with various systemic manifestations. … Her BCVAs recovered to 20/16 OU, and relapse of ocular inflammation and side effect of treatment were not observed during the 1.5-year follow-up period. …
NAID 120006716616

過去17年間に行った皮下免疫療法の検討

石津博子,森里美,津曲俊太郎,栗原和幸
アレルギー 68(8), 948-957, 2019
【背景】近年我が国では皮下免疫療法（SCIT）があまり行われなくなった．当科の過去17年間のアレルギー性鼻炎に対するSCITについて調査した．【方法】対象は2000年から16年間に入院して急速法で開始した188例．診療録より患者背景，検査所見，副反応を調査し，患者・保護者へ効果，満足度などのアンケートを実施した．<p …
NAID 130007709340

Lipid resuscitation：投与法とメカニズム，副作用についてのupdate

小田裕
日本臨床麻酔学会誌 39(3), 287-295, 2019
… 脂肪乳剤による局所麻酔薬中毒治療のメカニズムは，scavenging effectとnon-scavenging（direct）effectに大別される．前者は従来lipid sinkとされたものである．Non-scavenging effectとして，容量効果，心筋へのエネルギー供給の改善，ミトコンドリアの保護作用，インスリンシグナリングの改善などが挙げられる．米国区域麻酔学会から発表されている「局所麻酔薬中毒治療のチェックリ …
NAID 130007665083