PIVKA-II
WordNet
- reason or establish by induction
- cause to arise; "induce a crisis" (同)bring_on
- produce electric current by electrostatic or magnetic processes (同)induct
- cause to do; cause to act in a specified manner; "The ads induced me to buy a VCR"; "My children finally got me to buy a computer"; "My wife made me buy a new sofa" (同)stimulate, cause, have, get, make
- cause to occur rapidly; "the infection precipitated a high fever and allergic reactions" (同)stimulate, rush, hasten
- failure to be present
- the occurrence of an abrupt, transient loss or impairment of consciousness (which is not subsequently remembered), sometimes with light twitching, fluttering eyelids, etc.; common in petit mal epilepsy (同)absence_seizure
- the state of being absent; "he was surprised by the absence of any explanation"
- the time interval during which something or somebody is away; "he visited during my absence"
- so as to pass a given point; "every hour a train goes past" (同)past
- United States guitar player and singer of the blues (born in 1925) (同)B. B. King, Riley B King
- United States woman tennis player (born in 1943) (同)Billie Jean King, Billie Jean Moffitt King
- United States charismatic civil rights leader and Baptist minister who campaigned against the segregation of Blacks (1929-1968) (同)Martin Luther King, Martin Luther King Jr.
- street names for ketamine (同)jet, super acid, special K, honey oil, green, cat valium, super C
- the 11th letter of the Roman alphabet (同)k
PrepTutorEJDIC
- 〈人〉‘に'『勧めて』(…)『させる』 / …‘を'『引き起こす』,もたらす(cause) / 〈電気〉‘を'誘導する / …‘を'帰納する
- 〈U〉〈C〉『るす』,不在;『欠席』;不在期間;(…を)欠席すること《+『from』+『名』》 / 〈U〉(…が)『ないこと』,(…の)欠如(lacking)《+『of』+『名』》
- 《場時・位置》…『のそばに』,の近くに;…の手もとに / 《経路・通過》…を経由して,を通って,のそばを通って / 《期限・期間》…『までに』,『の間に』 / 《根拠・理由》…『によって』,に従って,に基づいて / …『を単位として』 / 《差・程度》…だけ / 《手段・方法》…『で』,『によって』,を使って / …が原因で,…の結果 / 《動作を受ける部分を示して》…を,のところを / 《受動態で動作の主体を表して》『…によって』 / …に関しては,については / …に誓って,の名において,にかけて / …ずつ,ごとに,の順番に / 《寸法・乗除》…で;…を / …に対して,のために / 《訪問場所》…に / 『そばに』,近くに / そばを通って / わきへ,取りのけて / 《時の経過》過ぎて
- Kelvin / Kindergarten / (チェスの)King / kalium(ラテン語)(=potassium)の化学記号
UpToDate Contents
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English Journal
- The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study.
- Mac-Way F1, Poulin A1, Utescu MS1, De Serres SA1, Marquis K2, Douville P3, Desmeules S1, Larivière R1, Lebel M4, Agharazii M1.
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.Nephrol Dial Transplant.2014 Nov;29(11):2113-20. doi: 10.1093/ndt/gfu224. Epub 2014 Jun 18.
- BACKGROUND: Accelerated progression of aortic stiffness in patients with advanced chronic kidney disease is not well explained by the traditional cardiovascular risk factors. We hypothesized that vitamin K deficiency may result in an accelerated progression of aortic stiffness in the pro-calcifying
- PMID 24944209
- Surgical resection after down-staging of locally advanced hepatocellular carcinoma by localized concurrent chemoradiotherapy.
- Lee HS1, Choi GH, Choi JS, Kim KS, Han KH, Seong J, Ahn SH, Kim do Y, Park JY, Kim SU, Kim BK.
- Annals of surgical oncology.Ann Surg Oncol.2014 Oct;21(11):3646-53. doi: 10.1245/s10434-014-3652-3. Epub 2014 Jun 11.
- BACKGROUND: This study evaluated the down-staging efficacy and impact on resectability of concurrent chemoradiotherapy (CCRT) followed by hepatic arterial infusion chemotherapy (HAIC) in locally advanced hepatocellular carcinoma, and identified prognostic factors of disease-free survival (DFS) and o
- PMID 24916746
- Triple positive tumor markers predict recurrence and survival in early stage hepatocellular carcinoma.
- Nakagawa S1, Beppu T, Okabe H, Sakamoto K, Kuroki H, Mima K, Nitta H, Imai K, Hayashi H, Sakamoto Y, Hashimoto D, Chikamoto A, Ishiko T, Watanabe M, Baba H.
- Hepatology research : the official journal of the Japan Society of Hepatology.Hepatol Res.2014 Sep;44(9):964-74. doi: 10.1111/hepr.12277. Epub 2014 Jan 8.
- AIM: Hepatectomy is feasible for patients with hepatocellular carcinoma (HCC) with good hepatic function who meet the Milan criteria. Several studies have indicated that tumor markers of HCC, α-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP percentage and protein induced by v
- PMID 24245496
Japanese Journal
- Positioning of novel tumor marker NX-PVKA-R in the diagnosis of hepatocellular carcinoma in comparison with PIVKA-II
- Suzuki Kazuyoshi,Tamano Masaya,Kuniyoshi Toru,Katayama Yasumi,Takada Hiroshi,Suzuki Kazutomo
- Dokkyo journal of medical sciences 40(3), 163-168, 2013-10-25
- … Background/Aims:To compare the use of protein induced by vitamin K absence or antagonist II( PIVKA-II) measured conventionally with the ratio between PIVKA-II measured using P-11 and P-16 antibodies(NX-PVKA) and PIVKA-II measured conventionally (NX-PVKA-R) in terms of false-positive …
- NAID 110009633113
- 自然止血していた肝細胞癌破裂に対して腹腔鏡下肝外側区域切除術を施行した1例
- 河岡 徹,深田 武久,桑原 太一,松隈 聰,金子 唯,原田 俊夫,平木 桜夫,福田 進太郎
- 山口医学 62(1), 61-66, 2013-02-01
- … を伴う上腹部腫瘤.CT, MRI, 超音波検査にてS3に約5cm大,肝表突出型で増大傾向を伴い,早期相で不均一に造影される単発性の肝腫瘍を認めた.肝機能は異常なく,HBs-Ag(-),HCV-Ab(-)であった.術直前のAFPは45071ng/ml, PIVKA-IIは8420mAU/mlと著明高値であった.以上より肝細胞癌を疑い,腹腔鏡下肝外側区域切除術を行うこととした.気腹後,腹腔内を観察したが,少量の血性腹水ならびに小網と膵臓に被覆された肝腫瘍を認め,破裂した肝細胞 …
- NAID 120005246299
- 去勢抵抗性前立腺癌と筋層浸潤性膀胱癌を併発した症例に対しGDC療法が奏効した1例
- 永田 雄大,原 貴彦,松山 豪泰 [他],松隈 聰,金子 唯,原田 俊夫,平木 桜夫,福田 進太郎,播磨 陽平,浦山 直樹,久野 興子,松崎 祐子,佐貫 和俊
- 西日本泌尿器科 = The Nishinihon journal of urology 75(1), 22-26, 2013-01
- … 腫瘤全体は早期で強く造影され,後期ではwash outされた.MRIではT1強調で低信号,T2強調で一部やや高信号であった.血管造影でも腫瘍は強く濃染された.PET-CTでは腫瘍に^{18}F-FDGの集積を認めなかった.AFPならびにPIVKA-IIは基準値内であった.肝細胞癌など悪性腫瘍の可能性も完全には否定出来ず,増大傾向を認めた為,診断かつ治療目的で,腹腔鏡補助下肝尾状葉突起部部分切除術を施行した.最終診断は肝血管筋脂肪腫(肝AML),筋腫型 …
- NAID 120005246292
Related Links
- Protein induced by vitamin K absence or antagonist-II versus alpha-fetoprotein in the diagnosis of hepatocellular carcinoma: A systematic review with meta-analysis Hepatobiliary Pancreat Dis Int . 2018 Dec;17(6):487-495. doi: 10.1016/j.hbpd.2018.09.009.
- Protein induced by vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients Scand J Gastroenterol . 2016 Oct;51(10):1257-62. doi: 10.1080/00365521.2016.1183705.
- Protein induced by vitamin K absence or antagonist II (PIVKA-II) is a putative specific marker of hepatocellular carcinoma (HCC), but it may also be produced by a small number of gastric cancers. To date, 16 cases of PIVKA-II
★リンクテーブル★
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- 英
- protein induced by vitamin K absence or antagonist-II
- 同
- γ-カルボキシル化異常プロトロンビン des-γ-carboxy prothrombin
- 関
- ビタミンK、ワルファリン、肝細胞癌
概念
- ビタミンK依存的にF II, VII, IX, X, Protein C, Protein SのGlu残基がGla(γ-カルボキシグルタミン酸)に変換され、補酵素としてCa2+を利用してリン脂質に結合し、セリンプロテアーゼとしての活性を持つようになる、はずである。ビタミンK非存在下ではこれらの蛋白質はGlu残基のまま、つまり活性を持たないまま末梢血に出現する。これらはそれぞれPIKVA-II,VII,IX,X,PC,PSなどと呼ばれるが、このうちPIVKA-IIがマーカーとして用いられている。
意義
- 肝細胞癌:直径2cm以下の微小肝細胞癌での陽性率は25-30%
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- 誘発する、誘導する、誘起する、導入する、引き起こす
- 関
- cause、challenge、derivation、elicit、elicitation、evocation、evoke、guidance、induction、inductive、introduce、introduction、precipitate、provocation、provoke、spark
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- 関
- absent、defect、deficiency、lack、morphological defect、nonexistent
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- hypercalcaemia induced pancreatitis 高カルシウム血症による膵炎