late-onset Alzheimer disease

• 遅発型アルツハイマー病

関

Alzheimer disease、Alzheimer's disease、early-onset Alzheimer disease、presenile dementia、senile dementia

WordNet

1. of a later stage in the development of a language or literature; used especially of dead languages; "Late Greek"
2. later than usual or than expected; "the train arrived late"; "we awoke late"; "the children came late to school"; "notice came so tardily that we almost missed the deadline"; "I belatedly wished her a happy birthday" (同)belatedly, tardily
3. at or toward an end or late period or stage of development; "the late phase of feudalism"; "a later symptom of the disease"; "later medical science could have saved the child" (同)later
4. of the immediate past or just previous to the present time; "a late development"; "their late quarrel"; "his recent trip to Africa"; "in recent months"; "a recent issue of the journal" (同)recent
5. at an advanced age or stage; "she married late"; "undertook the project late in her career"
6. being or occurring at an advanced period of time or after a usual or expected time; "late evening"; "late 18th century"; "a late movie"; "took a late flight"; "had a late breakfast"
7. having died recently; "her late husband"
8. an impairment of health or a condition of abnormal functioning
9. the beginning or early stages; "the onset of pneumonia" (同)oncoming
10. caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
11. the syllable naming the sixth (submediant) note of a major or minor scale in solmization (同)lah

PrepTutorEJDIC

1. (定刻・通常・予定の時間より)『遅れた』,遅い / (時刻が)『遅い』,遅く始まる,遅くまで続く;夜更けの / (時期が)『遅い』,終りごろの,後期の / 『最近の』,最新の(recent) / 《the~,one's~》『前の』,先の,前任の(former) / 《the~,one's~》『故』…,つい先ごろ死んだ / (定刻などより)『遅れて』,遅く / (時刻が)『遅く』,遅くまで,(特に)夜更けに;(時期が)遅く,終りごろに / 『最近』,近ごろ(recently)
2. (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
3. 女性の話術芸人 =diseur
4. 攻撃,襲撃 / (病気・季節などの)始まり,開始《+『of』+『名』》
5. 病気にかかった / 病的な,不健全な(morbid)
6. ラ(全音階の第6音)

UpToDate Contents

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• 1. アルツハイマー病の疫学、病理、および病因epidemiology pathology and pathogenesis of alzheimer disease [show details]
• 2. アルツハイマー病の遺伝学genetics of alzheimer disease [show details]
  …related to the endolysosomal pathway (eg, RUFY1, PSD2, TCIRG1, RIN3) . The genetic basis of late-onset Alzheimer disease (LOAD) is more complex, with susceptibility conferred by a variety of more common but …
• 3. 認知機能低下および認知症の危険因子risk factors for cognitive decline and dementia [show details]
• 4. オーダーメイド医療personalized medicine [show details]
  …10 conditions that include celiac disease, factor XI deficiency, G6PD deficiency, and late-onset Alzheimer disease; results of this testing might result in lifestyle modifications and/or discussions with…
• 5. 遺伝子検査での二次的所見secondary findings from genetic testing [show details]
  …from a trial involving 257 adults who were interested in learning about genetic risk for late onset Alzheimer disease (AD) . Participants had genotyping of their apolipoprotein E (APOE) gene, which is associated…

English Journal

• Synthesis and biological evaluation of 3-arylcoumarins as potential anti-Alzheimer's disease agents.

• Yang J, Zhang P, Hu Y, Liu T, Sun J, Wang X.
• Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)651-656.
• Alzheimer's disease, a neurodegenerative illness, has the extremely complex pathogenesis. Accumulating evidence indicates there is a close relationship between several enzymes and Alzheimer's disease. Various substituted 3-arylcoumarin derivatives were synthesised, and their in vitro activity, inclu
• PMID 30746966

• Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

• Pachón-Angona I, Refouvelet B, Andrýs R, Martin H, Luzet V, Iriepa I, Moraleda I, Diez-Iriepa D, Oset-Gasque MJ, Marco-Contelles J, Musilek K, Ismaili L.
• Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)479-489.
• We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer's disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC
• PMID 30712420

• Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy.

• Dgachi Y, Martin H, Malek R, Jun D, Janockova J, Sepsova V, Soukup O, Iriepa I, Moraleda I, Maalej E, Carreiras MC, Refouvelet B, Chabchoub F, Marco-Contelles J, Ismaili L.
• Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)163-170.
• In view of the multifactorial nature of Alzheimer's disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer's disease therapy. The new MTSM KojoTacrines (KTs) were designed and synthesized by juxtaposition of se
• PMID 30482062

Japanese Journal

• 若年発症アルツハイマー病と高齢発症アルツハイマー病 (特集 アルツハイマー病の多様性)

• 老年精神医学雑誌 26(8), 853-858, 2015-08
• NAID 40020571758

• 高齢発症アルツハイマー病患者における発症年齢,アポリポタンパクEと臨床症状との関係 : 前期高齢発症群と後期高齢発症群の比較

• 老年精神医学雑誌 25(1), 61-69, 2014-01
• NAID 40019977628

• 晩期発症型アルツハイマー病とSORL1のゲノム関連解析

• 新潟医学会雑誌 127(11), 605-619, 2013-11
• NAID 40020020919

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★リンクテーブル★

リンク元	「early-onset Alzheimer disease」「presenile dementia」「senile dementia」「遅発型アルツハイマー病」
関連記事	「disease」「onset」「late」

「early-onset Alzheimer disease」

　　[★]

早期発症型アルツハイマー病、早期発症型Alzheimer病

関

Alzheimer disease、Alzheimer's disease、late-onset Alzheimer disease、presenile dementia、senile dementia

「presenile dementia」

　　[★]

• 初老期認知症、初老期痴呆

関

Alzheimer disease、Alzheimer's disease、early-onset Alzheimer disease、late-onset Alzheimer disease、senile dementia

「senile dementia」

　　[★] 老年認知症、老年痴呆

関

Alzheimer disease、Alzheimer's disease、early-onset Alzheimer disease、late-onset Alzheimer disease、presenile dementia

「遅発型アルツハイマー病」

　　[★]

英

late-onset Alzheimer disease

関

アルツハイマー病、老年痴呆、初老期痴呆、早期発症型アルツハイマー病

「disease」

　　[★]

• n.

疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)

特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)

• something that is very wrong with people's attitudes, way of life or with society.

関

ail、ailment、disease entity、disorder、ill、illness、malady、sick、sickness

• 注意

disease ≠ illness ≠ disorder

　 　 　

「onset」

　　[★]

• n.

• 襲撃、攻撃。(病気などの)始まり、開始、襲来。着手、手始め

関

affect、commence、commencement、develop、development、developmental、emergence、engender、episode、event、generate、generation、initiate、initiation、institute、mount、occur、occurrence、pathogenesis、start、symptom onset、transpire

　 　

「late」

　　[★]

• adv.

• (比較級later-最上級latest)遅い、遅発の、遅発型の、晩発の、後の、後期の

関

after、afterward、afterwards、anaphase、behind、delayed、following、late-stage、post、posterior、slow、subsequent