WordNet
- place signs, as along a road; "sign an intersection"; "This road has been signed"
- (medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
- a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
- a character indicating a relation between quantities; "dont forget the minus sign"
- a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
- a gesture that is part of a sign language
- a public display of a message; "he posted signs in all the shop windows"
- engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
- approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
- communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
- mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
- be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
- communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
- watch and study birds in their natural habitat (同)birdwatch
- warm-blooded egg-laying vertebrates characterized by feathers and forelimbs modified as wings
- the flesh of a bird or fowl (wild or domestic) used as food (同)fowl
- the act of singing with closed lips
- having a handwritten signature; "a signed letter"
PrepTutorEJDIC
- (ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
- 『鳥』 / 〈話〉《修飾語を伴なって(目立った特徴をもった)やつ,人 / 〓shuttlecock / 《英俗》女 / 《俗》《the bird》(分満を表す)し‐っし‐っという野次《形容詞的に》『bird feathers』{名}鳥の羽『bird life』{名}〈U〉鳥の生活
- (虫・機械などが)ブンブンいう(うなる);鼻歌を歌う,ハミングで歌う / 《話》(商売などが)活発な,活気のある
- =ti
UpToDate Contents
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English Journal
- [Detection of cerebral hypoperfusion using single photon emission computed tomography image analysis and statistical parametric mapping in patients with Parkinson's disease or progressive supranuclear palsy].
- Harada K1, Saeki H, Matsuya E, Okita I.
- Nihon Hoshasen Gijutsu Gakkai zasshi.Nihon Hoshasen Gijutsu Gakkai Zasshi.2013 Nov;69(11):1281-4.
- Purpose: We carried out differential diagnosis of brain blood flow images using single-photon emission computed tomography (SPECT) for patients with Parkinson's disease (PD) or progressive supranuclear paralysis (PSP) using statistical parametric mapping (SPM) and to whom we had applied anatomical s
- PMID 24256652
- [MRI diagnosis of neurodegenerative disorders].
- Iwata M.
- Rinshō shinkeigaku = Clinical neurology.Rinsho Shinkeigaku.2005 Nov;45(11):947-51.
- Routine use of high field MRI has greatly contributed to the clinical diagnosis of neurodegenerative disorders, because MRI enables to visualize degenerative process showing either atrophy of the specific areas or degeneration of specific structures. Among many specific MRI signs which have been hit
- PMID 16447770
- [Neuroimaging of motor disturbances].
- Iwata M.
- Rinshō shinkeigaku = Clinical neurology.Rinsho Shinkeigaku.1998 Dec;38(12):1010-2.
- High-field MRI has given us a great impact in the clinical diagnosis of various motor disturbances, because the structural abnormalities of the pyramidal tract, basal ganglia and cerebellum are easily observed with this technique. In case of lower motor neuron disease without clinical upper motor ne
- PMID 10349340
Japanese Journal
- SPMを用いたパーキンソン病と進行性核上性麻痺の比較による特徴的な血流低下の検出
- 片眼性滑車神経麻痺の視能矯正中に融像衰弱を認めた進行性核上性麻痺疑いの1例
Related Links
- 血液検査、髄液検査脳MRI:中脳背側部(中脳被蓋>中脳蓋)の萎縮に伴う Hummingbird sign、第3脳室の拡大、前頭葉萎縮脳 ... 萎縮した中脳正中吻側部が ハチドリの嘴に見えるためHummingbird signとも呼ばれています黄矢印:それぞれ四 丘体の上丘を ...
★リンクテーブル★
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- 英
- progressive supranuclear palsy PSP
- 同
- 進行性核上麻痺、スティール・リチャードソン・オルゼウスキー症候群 スティール-リチャードソン-オルシェウスキィ症候群 Steele-Richardson-Olszewski syndrome
- 関
- パーキンソン症候群
[show details]
概念
- 難病であり、特定疾患治療研究事業の対象疾患である。
- 大脳基底核や脳幹が障害され、核上性注視麻痺とパーキンソニズムを中核症状として呈する慢性進行性変性疾患
- 中年期以降男性に好発し、易転倒性、核上性注視麻痺、パーキンソニズム、認知症などを特徴とする原因不明の疾患である。病理学的には淡蒼球、視床下核、小脳歯状核、赤核、黒質、脳幹被蓋の神経細胞が脱落し、異常リン酸化タウ蛋白が神経細胞内およびグリア細胞内に蓄積が見られる。(参考1)
症状
- 後方への転倒傾向(歩行障害。姿勢反射障害に基づく) が特徴
- 1. 項筋の緊張亢進:頭部背屈(項部ジストニア)
- 2 垂直性核上性眼球運動障害(垂直方向、特に下方への眼球運動制限)
- 下方注視障害により階段を降りることが困難。末期には水平運動も障害される。
- 3 パーキンソニズム:筋強剛が前景に出る(振戦は稀)。動作緩徐、姿勢反射障害
- 4 精神障害:皮質下性認知症(前頭側頭型認知症に類似)
- 5 偽性球麻痺:構音障害、嚥下障害
- ※ すくみ足が前景に出る場合はpure akinesia またはPSP-Pと呼ぶ
検査
治療
- L-ドーパやドパミンアゴニストなどのドパミン作動薬は無効
- 三環系抗うつ薬が有効であるという報告がある。アミトリプチリン
参考
- 1. パーキンソン病関連疾患 (1)進行性核上性麻痺 - 難病情報センター
- http://www.nanbyou.or.jp/entry/276
- http://www.jsnp.jp/cerebral_14.htm
<youtube>https://www.youtube.com/watch?v=BPt3pTzbcXc</youtube>
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- 関
- indication、manifestation、signature、stigma、stigmata、symptom、symptomatic
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- 関
- Aves、avian