WordNet
- periwinkle plant derivative used as an antineoplastic drug (trade name Oncovin); used to treat cancer of the lymphatic system (同)Oncovin
- the 20th letter of the Roman alphabet (同)t
PrepTutorEJDIC
- tritiumの化学記号
- Teachers College 教員養成大学
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English Journal
- Vincristine liposomal--INEX: lipid-encapsulated vincristine, onco TCS, transmembrane carrier system--vincristine, vincacine, vincristine sulfate liposomes for injection, VSLI.
- [No authors listed]
- Drugs in R&D.Drugs R D.2004;5(2):119-23.
- INEX Pharmaceuticals is developing a liposomal formulation of vincristine [Onco TCS, vincacine, VSLI, Vincristine sulfate liposomes for injection] for the treatment of relapsed aggressive non-Hodgkin's lymphoma (NHL) and other cancers. It is being developed using INEX's proprietary drug-delivery tec
- PMID 15293876
- Liposomal vincristine in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial.
- Sarris AH1, Hagemeister F, Romaguera J, Rodriguez MA, McLaughlin P, Tsimberidou AM, Medeiros LJ, Samuels B, Pate O, Oholendt M, Kantarjian H, Burge C, Cabanillas F.
- Annals of oncology : official journal of the European Society for Medical Oncology / ESMO.Ann Oncol.2000 Jan;11(1):69-72.
- OBJECTIVE: Vincristine is an active agent in lymphomas, but is often neurotoxic, and the resulting dose reductions have been associated with lower remission and survival rates in Hodgkin's disease. Liposomal vincristine (Onco-TCS) has prolonged half-life, reaches higher concentration in tumors and l
- PMID 10690390
- Phase I study of liposomal vincristine.
- Gelmon KA1, Tolcher A, Diab AR, Bally MB, Embree L, Hudon N, Dedhar C, Ayers D, Eisen A, Melosky B, Burge C, Logan P, Mayer LD.
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology.J Clin Oncol.1999 Feb;17(2):697-705.
- PURPOSE: A phase I study of vincristine encapsulated inside 120-nm-diameter distearoylphosphatidylcholine-cholesterol liposomes was performed. The primary objectives were to determine the maximum-tolerated dose (MTD), recommended phase II dose, toxicity, and pharmacokinetics of liposomal vincristine
- PMID 10080616
Related Links
- Onco TCS Vincristine Liposomal Vincristine (brand name, Oncovin), formally known as leurocristine, sometimes abbreviated "VCR", is a vinca alkaloid from the Catharanthus roseus (Madagascar periwinkle), formerly Vinca rosea and ...
- Onco TCS Brand names, Onco TCS Analogs 22-Oxovincaleukoblastine Indole alkaloid LCR Leurocristine Onco TCS Oncovin Oncovin (1:1 sulfate salt) VCR VIN Vincaleukoblastine, 22-oxo-Vincasar (1:1 sulfate salt) Vincasar PFS ...
Related Pictures
★リンクテーブル★
| リンク元 | 「ビンクリスチン」 |
| 関連記事 | 「TC」「T」「onco」「TCS」 |
「ビンクリスチン」
- 英
- vincristine, VCR
- 同
- 硫酸リューロクリスチン leurocristine sulfate
- 化
- 硫酸ビンクリスチン vincristine sulfate
- 商
- ONCO-TCS、ONCOVIN、VINCASAR PFS、オンコビン oncovin
- 関
- first aid step1 2006 p.84,310
特徴
構造
作用機序
- M-phase-specific alkaloids that bind to tubulin and block polymerization of microtubules so that mitotic spindle cannot form (first aid step1 2006 p.310)
適応
- part of the MOPP (Oncovin [vincristine]) regimen for lymphoma, Wilms' tumor, choriocarcinoma(first aid step1 2006 p.310)
- MAPP regimen for Hodgkin disease, ALL lymphoma, CNS tumer, sarcoma, Wilms tumor
効能又は効果
- 1. 白血病（急性白血病、慢性白血病の急性転化時を含む）
- 2. 悪性リンパ腫（細網肉腫、リンパ肉腫、ホジキン病）
- 3. 小児腫瘍（神経芽腫、ウィルムス腫瘍、横紋筋肉腫、睾丸胎児性癌、血管肉腫等）
- 4. 以下の悪性腫瘍に対する他の抗悪性腫瘍剤との併用療法
副作用
- vincristine：neurotoxicity (areflexia, peripheral neuritis), paralytic ileus
- vinblastine：bone marrow suppression
「TC」
「T」
「onco」
- comb form.