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Hyaluronan oligomers sensitize chronic myeloid leukemia cell lines to the effect of Imatinib.

Lompardía SL1, Díaz M1, Papademetrio DL1, Mascaró M1, Pibuel M1, Álvarez E2, Hajos SE1.
Glycobiology.Glycobiology.2016 Apr;26(4):343-52. doi: 10.1093/glycob/cwv107. Epub 2015 Nov 17.
Chronic myeloid leukemia is a myeloproliferative syndrome characterized by the presence of the Philadelphia chromosome (Ph), generated by a reciprocal translocation occurring between chromosomes 9 and 22 [t(9;22)(q34;q11)]. As a consequence, a fusion gene (bcr-abl) encoding a constitutively active k
PMID 26582603

Metronomic maintenance chemotherapy in patients presenting with paraneoplastic autoimmune hepatitis with recurrent thymic carcinoma.

Kivrak Salim D1, Mutlu H2, Karakurt Eryilmaz M2, Yalçin Musri F2, Tural D2, Coşkun HŞ2.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.J Oncol Pharm Pract.2016 Apr;22(2):313-315. Epub 2014 Sep 16.
Autoimmune hepatitis is a rarely seen autoimmune paraneoplastic syndrome of thymic carcinoma. Chemotherapy may be an effective choice in the treatment of primary tumor and paraneoplastic disorder. In this case, we report a 32-year-old man presented with increased liver enzymes and cholestasis with a
PMID 25231462

Vincristine sulfate loaded dextran microspheres amalgamated with thermosensitive gel offered sustained release and enhanced cytotoxicity in THP-1, human leukemia cells: In vitro and in vivo study.

Thakur V1, Kush P1, Pandey RS2, Jain UK1, Chandra R3, Madan J4.
Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2016 Apr 1;61:113-22. doi: 10.1016/j.msec.2015.12.015. Epub 2015 Dec 12.
Vincristine sulfate (VCS) is a drug of choice for the treatment of childhood and adult acute lymphocytic leukemia, Hodgkin's, non-Hodgkin's lymphoma as well as solid tumors including sarcomas. However, poor biopharmaceutical and pharmacokinetic traits of VCS like short serum half-life (12min), high
PMID 26838831

ビンカアルカロイドの一つで、チューブリンに結合して微小管の重合(紡錘体の形成を含む)を阻害して細胞増殖を抑制する。　⇔ (パクリタキセルは微小管の脱重合を阻害)

M-phase-specific alkaloids that bind to tubulin and block polymerization of microtubules so that mitotic spindle cannot form (first aid step1 2006 p.310)

part of the MOPP (Oncovin [vincristine]) regimen for lymphoma, Wilms' tumor, choriocarcinoma(first aid step1 2006 p.310)
MAPP regimen for Hodgkin disease, ALL lymphoma, CNS tumer, sarcoma, Wilms tumor