WordNet

periwinkle plant derivative used as an antineoplastic drug (trade name Oncovin); used to treat cancer of the lymphatic system (同)Oncovin
the 16th letter of the Roman alphabet (同)p

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Post-treatment PET-CT Findings may Predict the Prognosis of DLBCL with a Bulky Mass.

Takasaki H1, Yamamoto W1, Ishii Y1, Takahashi H1, Watanabe R1, Harada T1, Kawasaki R1, Hashimoto C1, Motomura S1, Tomita N2, Ishigatsubo Y2, Sakai R1.
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion.Indian J Hematol Blood Transfus.2015 Sep;31(3):346-51. doi: 10.1007/s12288-014-0479-9. Epub 2014 Dec 3.
We retrospectively analyzed the prognosis of patients with diffuse large B cell lymphoma (DLBCL) and a bulky mass at diagnosis. We retrospectively analyzed clinical data for 29 consecutive DLBCL patients with an initial bulky mass receiving R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristi
PMID 26085719

Eribulin synergizes with Polo-like kinase 1 inhibitors to induce apoptosis in rhabdomyosarcoma.

Stehle A1, Hugle M1, Fulda S2.
Cancer letters.Cancer Lett.2015 Aug 28;365(1):37-46. doi: 10.1016/j.canlet.2015.04.011. Epub 2015 Apr 23.
Eribulin, a novel microtubule-interfering drug, was recently shown to exhibit high antitumor activity in vivo against various pediatric cancers. Here, we identify a novel synthetic lethal interaction of Eribulin together with Polo-like kinase 1 (PLK1) inhibitors against rhabdomyosarcoma (RMS) in vit
PMID 25917079

Metastatic Malignant Transformation of Teratoma to Primitive Neuroectodermal Tumor (PNET): Results With PNET-based Chemotherapy.

Al-Hader AA1, Jain A, Al-Nasrallah N, Einhorn LH.
American journal of clinical oncology.Am J Clin Oncol.2015 Aug;38(4):364-6. doi: 10.1097/COC.0b013e31829d1ed7.
BACKGROUND: Metastatic germ cell cancers are highly chemosensitive and have 80% cure rate with cisplatin-based chemotherapy. Postchemotherapy teratoma can usually be surgically resected. However, teratoma, which is pluripotent tissue, can undergo malignant transformation along mesodermal elements to
PMID 23799289

ビンカアルカロイドの一つで、チューブリンに結合して微小管の重合(紡錘体の形成を含む)を阻害して細胞増殖を抑制する。　⇔ (パクリタキセルは微小管の脱重合を阻害)

M-phase-specific alkaloids that bind to tubulin and block polymerization of microtubules so that mitotic spindle cannot form (first aid step1 2006 p.310)

part of the MOPP (Oncovin [vincristine]) regimen for lymphoma, Wilms' tumor, choriocarcinoma(first aid step1 2006 p.310)
MAPP regimen for Hodgkin disease, ALL lymphoma, CNS tumer, sarcoma, Wilms tumor