WordNet
- determine the sum of; "Add all the people in this town to those of the neighboring town" (同)tot, tot up, sum, sum_up, summate, tote up, add, add together, tally, add up
- damage beyond the point of repair; "My son totaled our new car"; "the rock star totals his guitar at every concert"
- add up in number or quantity; "The bills amounted to $2,000"; "The bill came to $2,000" (同)number, add up, come, amount
- a small amount (especially of a drink); "a tot of rum"
- an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues (同)cholesterin
- used of automobiles; completely demolished; "the insurance adjuster declared the automobile totaled"
PrepTutorEJDIC
- Teachers College 教員養成大学
- technetium の化学記号
- 『総計の』,全体の / 『全くの』,完全な(absolute) / 『合計』,総額,総数,総量(sum) / …‘を'合計する / 合計…‘に'なる,総額が…‘に'のぼる(amount to)
- 幼児,小児 / (特に酒類の)少量,一杯,一口
- …‘を'合計する《+up+名,+名+up》 / 合計(…に)なる《+up to+名》
- コレステロール(胆汁・血液・神経組織などの脂肪性成分)
UpToDate Contents
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- 1. 血中脂質およびリポ蛋白の測定 measurement of blood lipids and lipoproteins
- 2. 脂質疾患に対するスクリーニング screening for lipid disorders
- 3. 二次予防における脂質（高コレステロール血症を含む）の治療 treatment of lipids including hypercholesterolemia in secondary prevention
- 4. 一次予防における脂質（高コレステロール血症を含む）の治療 treatment of lipids including hypercholesterolemia in primary prevention
- 5. HDLコレステロール：異常値の臨床的側面 hdl cholesterol clinical aspects of abnormal values
English Journal
- Circulating PCSK9 is a strong determinant of plasma triacylglycerols and total cholesterol in homozygous carriers of apolipoprotein ε2.
- Brouwers MC1, van Greevenbroek MM1, Konrad RJ2, Troutt JS2, Schaper NC1, Stehouwer CD1.Author information 1*Department of Internal Medicine, Divisions of General Internal Medicine and Endocrinology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maasctricht, The Netherlands.2†Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IA 46285, U.S.A.AbstractHomozygous carriers of the apolipoprotein ε2 allele are at risk of type III hyperlipidaemia, but do not necessarily develop this lipid disorder. In the present study, we have investigated the role of circulating PCSK9 (pro-protein convertase subtilisin kexin type 9), an important regulator of LDL (low-density lipoprotein) receptor expression, in the development of this hyperlipidaemic phenotype. In an observational study, plasma PCSK9 was measured in homozygous carriers of apolipoprotein ε2 (ε2/ε2; n=12), normal controls (n=72) and hypertriglyceridaemic patients with FCHL (familial combined hyperlipidaemia; n=38), who served as a hyperlipidaemic reference group. Cholesterol, triacylglycerols (triglycerides) and apolipoprotein B content in VLDL (very-low-density lipoprotein) and LDL particles was determined by ultracentrifugation in ε2/ε2 and FCHL patients. Median circulating PCSK9 levels did not differ between ε2/ε2 carriers compared with controls and hypertriglyceridaemic FCHL patients (84.5 compared with 82.0 and 84.9 ng/ml; P=0.2 and 0.6 respectively). Circulating PCSK9 was associated with total cholesterol and triacylglycerols levels in ε2/ε2 carriers (P<0.05). These associations were stronger in ε2/ε2 carriers when compared with controls (P values for interaction=0.01 and 0.02 respectively). A direct comparison with FCHL patients demonstrated a similar discrepancy for the association with plasma triacylglycerols and also VLDL-apolipoprotein B, cholesterol and triacylglycerols (P value for interaction=0.01, 0.01, 0.03 and 0.03 respectively). Plasma PCSK9 is associated with type III hyperlipidaemia. Its strong relationship with plasma triacylglycerols and total cholesterol distinguishes ε2/ε2 carriers from controls and another type of dyslipidaemia, which provides valuable information regarding the pathogenesis of this complex dyslipidaemia. Furthermore, these results suggest that patients with type III hyperlipidaemia may benefit from PCSK9-antagonizing therapy.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 May 1;126(9):679-84. doi: 10.1042/CS20130556.
- Homozygous carriers of the apolipoprotein ε2 allele are at risk of type III hyperlipidaemia, but do not necessarily develop this lipid disorder. In the present study, we have investigated the role of circulating PCSK9 (pro-protein convertase subtilisin kexin type 9), an important regulator of LDL
- PMID 24308640
- Modulation of Lipid Metabolism by Deep-Sea Water in Cultured Human Liver (HepG2) Cells.
- He S1, Hao J, Peng W, Qiu P, Li C, Guan H.Author information 1Key Laboratory of Marine Drugs, Ministry of Education, Marine Drugs and Food Institute, Ocean University of China, Qingdao, 266003, People's Republic of China.AbstractIt has been found that deep-sea water was associated with lower serum lipid in animal model studies. Herein, we investigated whether DSW exerted a hypolipidemic activity and further elucidated how DSW modulated lipid metabolism in HepG2 cells. Preliminary animal studies showed that DSW exhibited potency to decrease serum total cholesterol, triglycerides, and LDL cholesterol, and increase HDL cholesterol, and the hepatic lipid contents were also significantly lower in the DSW group. When DSW was added to HepG2 cells, it decreased the lipid contents of hepatocyte through the activation of AMP-activated protein kinase, thus inhibiting the synthesis of cholesterol and fatty acid. Besides, LDL receptor was upregulated by activation of sterol regulatory element-binding protein-2. In addition, the levels of apolipoprotein AI and cholesterol 7-alpha-hydroxylase were also raised. Our investigation provided mechanisms by which DSW modulated lipid metabolism and indicated that DSW was worthy of further investigation and could be developed as functional drinking water in the prevention and treatment of hypolipidemic and other lifestyle-related diseases.
- Marine biotechnology (New York, N.Y.).Mar Biotechnol (NY).2014 Apr;16(2):219-229. Epub 2013 Sep 24.
- It has been found that deep-sea water was associated with lower serum lipid in animal model studies. Herein, we investigated whether DSW exerted a hypolipidemic activity and further elucidated how DSW modulated lipid metabolism in HepG2 cells. Preliminary animal studies showed that DSW exhibited pot
- PMID 24057172
- Markers of cholesterol transport are associated with amyloid deposition in the brain.
- Hughes TM1, Lopez OL2, Evans RW3, Kamboh MI4, Williamson JD5, Klunk WE6, Mathis CA7, Price JC7, Cohen AD6, Snitz BE2, Dekosky ST8, Kuller LH5.Author information 1Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA. Electronic address: tmhughes@wakehealth.edu.2Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.3Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.4Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.5Department of Internal Medicine, School of Medicine, Wake Forest University, Winston-Salem, NC, USA.6Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.7Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.8University of Virginia School of Medicine, University of Virginia, Charlottesville, VA, USA.AbstractCholesterol is implicated in the development of late-onset Alzheimer's disease (AD). We sought to determine the associations between beta amyloid (Aβ) plaque deposition in vivo using Pittsburgh compound B (PiB) and several indices of cholesterol homeostasis (i.e., total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoprotein E (ApoE), clusterin, oxysterol metabolites of cholesterol, and previously reported genes associated with late-onset AD) in 175 nondemented elderly subjects. High Aβ deposition was associated significantly with a lower Mini-Mental State Examination score (<27 points, p = 0.04), high systolic blood pressure (p = 0.04), carrying the apolipoprotein E epsilon 4 allele (p < 0.01), and lower plasma ApoE levels (p = 0.02), and variation in the ABCA7 (p = 0.02) and EPHA1 genes (p = 0.02). Cholesterol measures were not related to Aβ deposition in this cohort of nondemented elderly adults. However, plasma and genetic factors relating to cholesterol transport were associated with Aβ deposition in the brain. A better understanding of cholesterol transport mechanisms may lead to the design of potential targets for the prevention of Aβ deposition in the brain.
- Neurobiology of aging.Neurobiol Aging.2014 Apr;35(4):802-7. doi: 10.1016/j.neurobiolaging.2013.09.040. Epub 2013 Oct 3.
- Cholesterol is implicated in the development of late-onset Alzheimer's disease (AD). We sought to determine the associations between beta amyloid (Aβ) plaque deposition in vivo using Pittsburgh compound B (PiB) and several indices of cholesterol homeostasis (i.e., total cholesterol, high-density li
- PMID 24199960
Japanese Journal
- 2 型糖尿病患者の血管内皮機能評価およびその関連因子の検討
- 鈴木 國弘,青木 千枝,飯嶋 寿江,田中 精一,二井谷 舞,城島 輝雄,麻生 好正
- Dokkyo journal of medical sciences 40(3), 169-174, 2013-10-25
- 要 旨 【目的】血管内皮機能障害は動脈硬化発症の端緒であり,糖尿病患者の血管障害を評価する上で非常に有用な生理学的機能検査である.そこで,実際の糖尿病診療をうけている患者の内皮機能を評価し,各種パラメータが与える影響を検討した.【方法】獨協医科大学内分泌代謝内科に通院している合併症のない2 型糖尿病患者に対して,臨床研究に同意した234名( 男性:133名,女性:101名)を対象として, 血管内皮 …
- NAID 110009633134
- 血清総コレステロール値と要介護認定リスクに関する前向きコホート研究 : 鶴ヶ谷プロジェクト
- 星 玲奈,遠又 靖丈,柿崎 真沙子 [他]
- 日本公衆衛生雑誌 = Japanese journal of public health 60(8), 435-443, 2013-08
- NAID 40019759911
- Association of ADRB2 polymorphism with triglyceride levels in Tongans
- Naka Izumi,Ohashi Jun,Kimura Ryosuke,Inaoka Tsukasa,Matsumura Yasuhiro,大橋 順
- Lipids in health and disease 12, 110, 2013-07
- … investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga.ResultsA multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly …
- NAID 120005323062
Related Links
- WebMD helps you make sense of your cholesterol level numbers, including LDL, HDL, and triglycerides. ... Cholesterol levels should be measured at least once every five years in everyone over age 20. The screening test ...
- Discover how you can instantly reduce cholesterol by using natural products and find out what food are best for you. ... Total Cholesterol sponsored links Cholesterol is known as a kind of fat which is a component of all animal tissue.
Related Pictures
★リンクテーブル★
| リンク元 | 「総コレステロール」「TC」「Tc」「T-CHO」 |
| 関連記事 | 「total」「cholesterol」 |
「総コレステロール」
- 英
- total cholesterol TC Tc, T-CHO
- 関
- コレステロール
基準値
- 130-220 mg/dL
QB
- 120-220 mg/dL
HIM A-10
- 単位：mg/dL (mmol/L)
- desirable: ＜200 (＜5.17)
- borderline high: 200?239 (5.17?6.18)
- high: ≧240 (≧6.21)
単位の変換
- 総コレステロールもLDLコレステロールもHDLコレステロールもmmol/Lをmg/dLに換算するには38.66535を掛ければ良い(参考1より)
測定への影響
- 食事の影響はない。
参考
- 1.
「TC」
「Tc」
- テクネチウム technetium
- キラーT細胞 Cytotoxic T cell
- 総コレステロール？ total cholesterol
「T-CHO」
[★] 総コレステロール total cholesterol
「total」
- n.