WordNet

limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
limit the range or extent of; "Contact between the young was inhibited by strict social customs"
a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
a light soft silver-white metallic element of the alkali metal group; oxidizes rapidly in air and reacts violently with water; is abundant in nature in combined forms occurring in sea water and in carnallite and kainite and sylvite (同)K, atomic number 19
a substance that retards or stops an activity
any compound containing a chlorine atom
any salt of hydrochloric acid (containing the chloride ion)

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1. バーター症候群およびギテルマン症候群 bartter and gitelman syndromes
2. 赤血球水分量の制御 control of red blood cell hydration
3. 利尿剤の作用機序 mechanism of action of diuretics
4. 低ナトリウム血症患者におけるナトリウム欠乏の評価 estimation of the sodium deficit in patients with hyponatremia
5. 浸透圧性脱髄症候群と低ナトリウム血症の過度に急速な補正 osmotic demyelination syndrome and overly rapid correction of hyponatremia

Tubuloglomerular and connecting tubuloglomerular feedback during inhibition of various Na transporters in the nephron.

Wang H1, D'Ambrosio MA1, Ren Y1, Monu SR1, Leung P1, Kutskill K1, Garvin JL2, Janic B1, Peterson EL3, Carretero OA4.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2015 May 1;308(9):F1026-31. doi: 10.1152/ajprenal.00605.2014. Epub 2015 Feb 25.
Afferent (Af-Art) and efferent arterioles resistance regulate glomerular capillary pressure. The nephron regulates Af-Art resistance via: 1) vasoconstrictor tubuloglomerular feedback (TGF), initiated in the macula densa via Na-K-2Cl cotransporters (NKCC2) and 2) vasodilator connecting tubuloglomerul
PMID 25715987

Na(+)-K(+)-2Cl(-) cotransporter-mediated fluid secretion increases under hypotonic osmolarity in the mouse submandibular salivary gland.

Kidokoro M1, Nakamoto T2, Mukaibo T1, Kondo Y1, Munemasa T1, Imamura A1, Masaki C1, Hosokawa R1.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2014 May 15;306(10):F1155-60. doi: 10.1152/ajprenal.00709.2012. Epub 2014 Mar 12.
Water-handling epithelia are sensitive to the osmotic environment. In this study, the effects of a hypo-osmotic challenge on carbachol (CCh)-induced fluid secretion was investigated using an ex vivo submandibular gland perfusion technique and intracellular pH and Ca(2+) measurements. The osmolality
PMID 24623142

Possible role of GABAergic depolarization in neocortical neurons in generating hyperexcitatory behaviors during emergence from sevoflurane anesthesia in the rat.

Lim BG1, Shen FY2, Kim YB3, Kim WB3, Kim YS3, Han HC3, Lee MK1, Kong MH1, Kim YI3.
ASN neuro.ASN Neuro.2014 Apr 4;6(2). pii: e00141. doi: 10.1042/AN20140004.
Hyperexcitatory behaviors occurring after sevoflurane anesthesia are of serious clinical concern, but the underlying mechanism is unknown. These behaviors may result from the potentiation by sevoflurane of GABAergic depolarization/excitation in neocortical neurons, cells implicated in the genesis of
PMID 24597723

リンク元	「ループ利尿薬」「ナトリウムカリウム塩素イオン共輸送体阻害薬」「ナトリウムカリウム塩素イオン共輸送体阻害剤」
関連記事	「inhibit」「inhibitor」「chloride」

	Na	K	Cl	H	Ca	Mg
血清	↓	↓		↓	↓	↓

GOO.752

過剰の投与によりナトリウムを喪失　→　低ナトリウム血症、細胞外液量減少　→　低血圧、GFR低下、循環虚脱、血栓塞栓の発生、(肝臓疾患が存在する場合)肝性脳症
過剰のナトリウムが遠位尿細管に到達する結果、(特にRAA系が体液喪失のために亢進していると)カリウムと水素イオンの排泄が亢進し、低Cl性アルカローシス(代謝性アシドーシス)を生じる。
もともと体内にKが欠乏していれば、不整脈が誘発される。特に強心配糖体を摂取していれば顕著となる(ジギタリス中毒)。

代謝性アシドーシス：ループ利尿薬乱用　→　(利尿薬)Cl喪失によるHCO3-の増加、およびK+喪失による血漿中H+の細胞内への移動による (QB.D-349 ICU.493 代謝性アルカローシス#原因による分類 ICU.493)
バーター症候群：Na⁺-K⁺-2Cl^-共輸送体の異常により、常にループ利尿薬が作用している病態をとる。