WordNet

the condition of being financially weak; "the weakness of the dollar against the yen"
the property of lacking physical or mental strength; liability to failure under pressure or stress or strain; "his weakness increased as he became older"; "the weakness of the span was overlooked until it collapsed"
a penchant for something even though it might not be good for you; "he has a weakness for chocolate"
desert (a cause, a country or an army), often in order to join the opposing cause, country, or army; "If soldiers deserted Hitlers army, they were shot" (同)desert
an imperfection in an object or machine; "a flaw caused the crystal to shatter"; "if there are any defects you should send it back to the manufacturer" (同)fault, flaw
an imperfection in a bodily system; "visual defects"; "this device permits detection of defects in the lungs"
a failing or deficiency; "that interpretation is an unfortunate defect of our lack of information" (同)shortcoming
(sports) a serve that is illegal (e.g., that lands outside the prescribed area); "he served too many double faults"
responsibility for a bad situation or event; "it was Johns fault"
(geology) a crack in the earths crust resulting from the displacement of one side with respect to the other; "they built it right over a geological fault"; "he studied the faulting of the earths crust" (同)faulting, geological fault, shift, fracture, break
(electronics) equipment failure attributable to some defect in a circuit (loose connection or insulation failure or short circuit etc.); "it took much longer to find the fault than to fix it"
unsatisfactoriness by virtue of being inadequate (同)inadequateness
the quality of being a hindrance; "he pointed out all the drawbacks to my plan"

PrepTutorEJDIC

欠点,禎所(fault) / 《英》《複数形》失敗;(要求された基準)に達しないこと
〈U〉(体・心・性格か)『弱いこと』《+of+名》 / 〈C〉『弱点』,短所 / 〈C〉(特に良くないものに対する)特別な好み,愛好《+for+名》
〈C〉『欠点』,弱点,欠陥 / 〈U〉〈C〉《古》不足,欠乏 / (国・党・主義などから)離脱する,裏切って出る《+『from』+『名』》;離反して(…に)転向する《+『to』+『名』》
〈C〉『欠点』,短所(defect) / 〈C〉『誤り』,落ち度 / 〈U〉(過失の)『責任』,罪 / 〈C〉断層(地層の食い違い) / 〈C〉フォールト(テニスなどでサーブの失敗) / …‘の'あら捜しをする / あやまちを犯す / 断層を生じる
(…に)不十分,不適当 / (…に)不十分なところ,不適当なところ《+『to』(『for』)+『名』》
(…の)障害,妨げ《+『to』+『名』》;不利,欠点,短所

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/24 19:10:30」(JST)

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1. 乳頭部腺腫の臨床症状および診断 clinical manifestations and diagnosis of ampullary adenomas
2. 左心室の評価における経食道心エコー transesophageal echocardiography in the evaluation of the left ventricle
3. 神経筋疾患および胸壁疾患における夜間の非侵襲的換気補助の種類 types of noninvasive nocturnal ventilatory support in neuromuscular and chest wall disease
4. 頚椎性頭痛 cervicogenic headache
5. 日焼け止めおよび太陽光線からの保護法の選択 selection of sunscreen and sun protective measures

English Journal

Engineered peptides for the development of actively tumor targeted liposomal carriers of doxorubicin.

Shahin M, Soudy R, El-Sikhry H, Seubert JM, Kaur K, Lavasanifar A.SourceFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E1.
Cancer letters.Cancer Lett.2013 Jul 1;334(2):284-92. doi: 10.1016/j.canlet.2012.10.007. Epub 2012 Oct 13.
Chemotherapy is still the treatment of choice for many types of cancer; but its effectiveness is hampered by dose limiting toxicity. Properly designed delivery systems can overcome this shortcoming by reducing the non-specific distribution and toxicity of chemotherapeutics in healthy organs and at t
PMID 23073474

Sedimentation behaviour in electrorheological fluids based on suspensions of zeolite particles in silicone oil.

Prekas K, Shah T, Soin N, Rangoussi M, Vassiliadis S, Siores E.SourceTechnological Education Institute (TEI), Piraeus, Athens, Greece.
Journal of colloid and interface science.J Colloid Interface Sci.2013 Jul 1;401:58-64. doi: 10.1016/j.jcis.2013.03.040. Epub 2013 Apr 4.
Sedimentation is a known and expected shortcoming of electrorheological fluids (ERFs) due to the inherent difference in the constituent densities. The long-term sedimentation causes loss of the electrorheological phenomenon and the exploitable electromechanical and viscoelastic properties despite th
PMID 23623409

A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.

Stewart R, Kozlov S, Matigian N, Wali G, Gatei M, Sutharsan R, Bellette B, Wraith-Kijas A, Cochrane J, Coulthard M, Perry C, Sinclair K, Mackay-Sim A, Lavin MF.AbstractThe autosomal recessive disorder ataxia-telangiectasia (A-T) is characterized by genome instability, cancer predisposition and neurodegeneration. Although the role of ataxia-telangiectasia mutated (ATM) protein, the protein defective in this syndrome, is well described in the response to DNA damage, its role in protecting the nervous system is less clear. We describe the establishment and characterization of patient-specific stem cells that have the potential to address this shortcoming. Olfactory neurosphere (ONS)-derived cells were generated from A-T patients, which expressed stem cell markers and exhibited A-T molecular and cellular characteristics that included hypersensitivity to radiation, defective radiation-induced signaling and cell cycle checkpoint defects. Introduction of full-length ATM cDNA into these cells corrected defects in the A-T cellular phenotype. Gene expression profiling and pathway analysis revealed defects in multiple cell signaling pathways associated with ATM function, with cell cycle, cell death and DNA damage response pathways being the most significantly dysregulated. A-T ONS cells were also capable of differentiating into neural progenitors, but they were defective in neurite formation, number of neurites and length of these neurites. Thus, ONS cells are a patient-derived neural stem cell model that recapitulate the phenotype of A-T, do not require genetic reprogramming, have the capacity to differentiate into neurons and have potential to delineate the neurological defect in these patients.
Human molecular genetics.Hum Mol Genet.2013 Jun 15;22(12):2495-509. doi: 10.1093/hmg/ddt101. Epub 2013 Mar 7.
The autosomal recessive disorder ataxia-telangiectasia (A-T) is characterized by genome instability, cancer predisposition and neurodegeneration. Although the role of ataxia-telangiectasia mutated (ATM) protein, the protein defective in this syndrome, is well described in the response to DNA damage,
PMID 23474819