1. a poisonous crystalline alkaloid extracted from the nightshade family; used as an antispasmodic and to dilate the eye pupil; also administered in large amounts as an antidote for organophosphate nerve agents or organophosphate insecticides
  2. a poisonous crystalline alkaloid (isometric with atropine but more potent); used to treat excess motility of the gastrointestinal tract

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/07/25 04:53:28」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

  • Evaluation of Anti-diarrheal Potential of Hydro-alcoholic Extracts of Leaves of Murraya koenigii in Experimental Animals.
  • Ramasamy A1, Das S2, Mani V3, Sengottuvelu S4, Vinoth Prabhu V1.
  • Journal of dietary supplements.J Diet Suppl.2016 Jul 3;13(4):393-401. doi: 10.3109/19390211.2015.1101636. Epub 2015 Dec 2.
  • BACKGROUND: The indigenous medical system of India mentions the use of Murraya koenigii leaves for the treatment of different types of diarrheas over ages.OBJECTIVE: To evaluate the anti-diarrheal activity of hydro-alcoholic extracts of leaves of Murraya koenigii and to check its effects on intestin
  • PMID 26631977
  • Electrophysiology and metabolism of caveolin-3-overexpressing mice.
  • Schilling JM1,2, Horikawa YT3,4, Zemljic-Harpf AE1,2, Vincent KP5, Tyan L6, Yu JK2, McCulloch AD5,7, Balijepalli RC6, Patel HH1,2, Roth DM8,9.
  • Basic research in cardiology.Basic Res Cardiol.2016 May;111(3):28. doi: 10.1007/s00395-016-0542-9. Epub 2016 Mar 29.
  • Caveolin-3 (Cav-3) plays a critical role in organizing signaling molecules and ion channels involved in cardiac conduction and metabolism. Mutations in Cav-3 are implicated in cardiac conduction abnormalities and myopathies. Additionally, cardiac-specific overexpression of Cav-3 (Cav-3 OE) is protec
  • PMID 27023865
  • Pharmacological evidence of α-adrenergic receptors in the hypotensive effect of Chamaemulum nobile L.
  • Hebi M, Ajebli M, El Bouhali B, Zeggwagh NA, Eddouks M1.
  • Cardiovascular & hematological agents in medicinal chemistry.Cardiovasc Hematol Agents Med Chem.2016 Apr 7. [Epub ahead of print]
  • This study aims to evaluate the underlying mechanism of action involved in the hypotensive effect of Chamaemulum nobile L. (Cn) aqueous extract and in anesthetized Wistar rats. Lyophilized aqueous extract was administered in the jugular vein, arterial blood pressure and heart rate were measured in t
  • PMID 27052027
  • Cholinergic activation of neurons in the medulla oblongata changes urinary bladder activity by plasma vasopressin release in female rats.
  • Cafarchio EM1, da Silva LA1, Auresco LC1, Ogihara CA1, Almeida RL1, Giannocco G1, Luz MC2, Fonseca FL2, Sato MA3.
  • European journal of pharmacology.Eur J Pharmacol.2016 Apr 5;776:116-23. doi: 10.1016/j.ejphar.2016.02.043. Epub 2016 Feb 13.
  • The central control of the micturition is dependent on cortical areas and other ascending and descending pathways in the brain stem. The descendent pathways from the pons to the urinary bladder (UB) can be direct or indirect through medullary neurons (MN). Chemical stimulation with l-glutamate of MN
  • PMID 26879866

Japanese Journal

  • インスリン抵抗性惹起因子としての糖尿病性自律神経障害
  • 高山 真一郎,岩本 安彦
  • 東京女子医科大学雑誌 81(E2), E253-E255, 2011-03-31
  • 糖尿病性自律神経障害は糖尿病合併症において、インスリン抵抗性は糖尿病の成因論において両者とも重要な位置にある。Lauttはインスリン抵抗性評価法であるRapid Insulin Sensitivity Testを用い実験動物において肝臓副交感神経遮断後インスリン抵抗性を生じたことから、インスリン→肝臓副交感神経賦活化→肝臓からhepatic insulin sensitizing substanc …
  • NAID 110008441477
  • Atropine Sulfate for Patients With Out-of-Hospital Cardiac Arrest due to Asystole and Pulseless Electrical Activity
  • YAGI Tsukasa,NAGAO Ken
  • Circulation journal : official journal of the Japanese Circulation Society 75(3), 580-588, 2011-02-25
  • … Background: The 2005 guidelines for cardiopulmonary resuscitation (CPR) have recommended that administration of atropine can be considered for non-shockable rhythm, but there are insufficient data in humans. … Methods and Results: The effects of atropine were assessed in 7,448 adults with non-shockable rhythm from the SOS-KANTO study. …
  • NAID 10028101887
  • Solid gastric emptying mediated by the serotonin (5-HT)_3 receptor in mice is a simple marker to predict emesis
  • ANDO Kentaro,TAKAGI Kan
  • Journal of toxicological sciences 36(1), 23-29, 2011-02-01
  • … The gastrointestinal transit test, the liquid gastric emptying by phenol red solution (Phenol red method) and the solid gastric emptying by resin beads (Beads method) were used and the effects of antispasmogenics (atropine, 0.1-3 mg/kg i.p.; …
  • NAID 10027420273

Related Links

atropine [at´ro-pēn] an anticholinergic alkaloid found in belladonna; it acts as a competitive antagonist of acetylcholine at muscarinic receptors, blocking stimulation of muscles and glands by parasympathetic and cholinergic ...
Atropine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: eye irritation and redness swelling of the eyelids sensitivity to bright light dry mouth red or dry skin blurred vision ...
Physician reviewed Atropine-1 patient information - includes Atropine-1 description, dosage and directions. ... What other drugs will affect Atropine-1 (atropine ophthalmic)? Tell your doctor about all your current medicines and any you ...

Related Pictures

拡張検索atropine methonitrate」「atropine methylbromide」「methylatropine」「opium alkaloid and atropine mixture」「etybenzatropine



硫酸アトロピン アトロピン硫酸塩 atropine sulfate臭化メチルアトロピン





  • 副交感神経の抑制


  • 低用量:徐脈
  • 増量時:頻脈


  • 唾液腺抑制→口渇、嚥下困難
  • 胃酸分泌抑制、胃腸管の緊張と運動抑制
  • 小腸、大腸、胆嚢、胆管の平滑筋の緊張をとり弛緩させる


  • 膀胱底の平滑筋が弛緩し、括約筋が収縮して、排尿困難、尿閉


  • 気管支平滑筋にはあまり作用しない
  • 気道分泌抑制

  • 散瞳、眼内圧上昇、毛様体筋弛緩による調節麻痺


  • 汗腺は交換神経支配であるが、コリン作動性であるので、発汗が抑制される


  • 中毒量で興奮作用が現れ、運動失調、不穏、興奮、幻覚、せん妄、錯乱、狂躁状態となる


  • 脳血管関門を通過


  • 胃・十二指腸潰瘍における分泌並びに運動亢進
  • 胃腸の痙攣性疼痛
  • 痙攣性便秘
  • 胆管・尿管の疝痛
  • 有機燐系殺虫剤・副交感神経興奮剤の中毒
  • 迷走神経性徐脈及び迷走神経性房室伝導障害
  • 麻酔前投薬
  • その他の徐脈及び房室伝導障害
  • ECTの前投与


Advanced Cardiovascular Life Support Provider manual ISBN 978-1-61669-010-6 p.166
  • (ACLSにおける)徐脈:0.5mg静注を3-5分置きに行う。total 0.04mg/kg(3mg)を超えないこと。
  • 有機リン中毒:2-4mgあるいはそれ以上


  • 1. 緑内障の患者[抗コリン作用により房水通路が狭くなり眼圧が上昇し,緑内障を悪化させるおそれがある.]
  • 2. 前立腺肥大による排尿障害のある患者[抗コリン作用による膀胱平滑筋の弛緩,膀胱括約筋の緊張により,排尿困難を悪化させるおそれがある.]
  • 3. 麻痺性イレウスの患者[抗コリン作用により消化管運動を抑制し,症状を悪化させるおそれがある.]
  • 4. 本剤の成分に対し過敏症の既往歴のある患者


Advanced Cardiovascular Life Support Provider manual ISBN 978-1-61669-010-6 p.166)
  • 心筋虚血や低酸素血症の場合、心筋酸素需要を増大させるので注意する。
  • 低体温による徐脈では使用を避ける
  • Morbit II型のII度房室ブロック(intranodal block)やIII度房室ブロックでは有効でないであろう(paradoxical slowing) ← カテコラミンを使う
  • (ACLSにおいて)<0.5mgの用量で静注した場合、paradoxical slowingが起こるかもしれない。


  • アトロピン注0.05%シリンジ「テルモ」(1mL)



muscarinic receptor antagonist
ムスカリン受容体遮断薬抗ムスカリン様作用薬、antimuscarinic drug
  • 気道閉塞性障害
臭化ブチルスコポラミン scopolamine butylbromide
製品名:ブスコパン Buscopan
チキジウム tiquizium




atropineatropine sulfatehyoscyamine methylbromide, Donnatal


atropine methonitrate」


atropineatropine methylbromideatropine sulfatemethylatropine

atropine methylbromide」


atropineatropine methonitrateatropine sulfatemethylatropine




atropine methonitrateatropine methylbromide

opium alkaloid and atropine mixture」

  [★] アヘンアルカロイド・アトロピン合剤